نتائج البحث - "G. Todd Milne"

1

Pharmacokinetics, mass balance, tissue distribution, metabolism, and excretion of praliciguat, a clinical‐stage soluble guanylate cyclase stimulator in rats

المؤلفون: Jenny Tobin, Albert T. Profy, Ali R. Banijamali, Mark G. Currie, James Wakefield, Jaime L. Masferrer, G. Todd Milne, Daniel P. Zimmer, Andrew Carvalho, Peter Germano, Barden Timothy Claude

المصدر: Pharmacology Research & Perspectives
Pharmacology Research & Perspectives, Vol 8, Iss 2, Pp n/a-n/a (2020)

مصطلحات موضوعية: Male, medicine.medical_specialty, sGC, Metabolite, praliciguat, Glucuronidation, Adipose tissue, RM1-950, 030226 pharmacology & pharmacy, Excretion, Rats, Sprague-Dawley, 03 medical and health sciences, chemistry.chemical_compound, Feces, 0302 clinical medicine, Soluble Guanylyl Cyclase, Pharmacokinetics, Oral administration, nitric oxide, Internal medicine, QWBA, medicine, Animals, Bile, Rats, Long-Evans, Tissue Distribution, General Pharmacology, Toxicology and Pharmaceutics, Original Articles, Bioavailability, cGMP, Endocrinology, Pyrimidines, Neurology, chemistry, 030220 oncology & carcinogenesis, Pyrazoles, Original Article, excretion, Therapeutics. Pharmacology, absorption, metabolism, pharmacokinetics, Drug metabolism, mass balance

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0b3e4df24159164c127118e8e21c0b4Test
http://europepmc.org/articles/PMC7171252Test

2

Olinciguat, an Oral sGC Stimulator, Exhibits Diverse Pharmacology Across Preclinical Models of Cardiovascular, Metabolic, Renal, and Inflammatory Disease

المصدر: Frontiers in Pharmacology
Frontiers in Pharmacology, Vol 11 (2020)

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::235faf214a0dad4f1fdd0e1ad72b1cd8Test
https://pubmed.ncbi.nlm.nih.gov/32322204Test

3

An exploratory, randomised, placebo-controlled, 14 day trial of the soluble guanylate cyclase stimulator praliciguat in participants with type 2 diabetes and hypertension

المؤلفون: Linda Morrow, Daniel P. Zimmer, Jennifer G. Chickering, Jelena P. Seferovic, Andrew L. Frelinger, Kenneth E. Carlson, Phebe J. Wilson, Mark G. Currie, G. Todd Milne, James Wakefield, Joon Jung, Albert T. Profy, John P. Hanrahan, Michael Hall, Alan D. Michelson

المصدر: Diabetologia

مصطلحات موضوعية: 0301 basic medicine, Adult, Male, medicine.medical_specialty, Mean arterial pressure, Endocrinology, Diabetes and Metabolism, Type 2 diabetes, 030204 cardiovascular system & hematology, Placebo, Soluble guanylate cyclase stimulator, Article, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Insulin resistance, BP, Double-Blind Method, Internal medicine, Internal Medicine, Medicine, Humans, Hypoglycemic Agents, Insulin, Diabetic Nephropathies, Cyclic guanosine monophosphate, Adverse effect, Aged, business.industry, Guanylyl Cyclase C Agonists, Endothelial function, Middle Aged, medicine.disease, 030104 developmental biology, Pyrimidines, Treatment Outcome, chemistry, Tolerability, Diabetes Mellitus, Type 2, Hyperlipidaemia, Pharmacodynamics, Hypertension, Pyrazoles, Drug Therapy, Combination, Female, business, Asymmetric dimethylarginine

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63b4281f0807fbb3e5d7d441113ef655Test
https://pubmed.ncbi.nlm.nih.gov/31858186Test

4

Fourteen-Day Study of Praliciguat, a Soluble Guanylate Cyclase Stimulator, in Patients with Diabetes and Hypertension

المؤلفون: Albert T. Profy, John P. Hanrahan, Michael Hall, Linda Morrow, Jennifer Chickering, G. Todd Milne, Mark Currie, Paul Miller, James D. Wakefield, Phebe J. Wilson

المصدر: Diabetes. 67

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::4277c36ca5d30aba676de72973390b0fTest
https://doi.org/10.2337/db18-74-orTest

5

A Randomized, Placebo-Controlled, Multiple-Ascending-Dose Study to Assess the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of the Soluble Guanylate Cyclase Stimulator Praliciguat in Healthy Subjects

المؤلفون: Albert T. Profy, G. Todd Milne, Marina Mihova, Michael Hall, Dennis Ruff, James Wakefield, Phebe J. Wilson, Mark G. Currie, Jennifer G. Chickering, John P. Hanrahan

المصدر: Clinical pharmacology in drug development. 8(5)

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::250b35c417ffa1a1a47e3581662896d2Test
https://pubmed.ncbi.nlm.nih.gov/30422390Test

6

Soluble Guanylate Cyclase Stimulators and Activators

المؤلفون: Johannes-Peter Stasch, Markus Follmann, Adrian J. Hobbs, Daniel P. Zimmer, Peter Sandner, G. Todd Milne

المصدر: Reactive Oxygen Species ISBN: 9783030685096

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::2e443ca9776cb93a4aac2a929355119aTest
https://doi.org/10.1007/164_2018_197Test

7

Pharmacological Characterization of IW-1973, a Novel Soluble Guanylate Cyclase Stimulator with Extensive Tissue Distribution, Antihypertensive, Anti-Inflammatory, and Antifibrotic Effects in Preclinical Models of Disease

المصدر: The Journal of pharmacology and experimental therapeutics. 365(3)

مصطلحات موضوعية: 0301 basic medicine, Male, Endothelium, medicine.medical_treatment, Anti-Inflammatory Agents, Inflammation, Blood Pressure, 030204 cardiovascular system & hematology, Pharmacology, Kidney, Nitric Oxide, Nitric oxide, Diabetic nephropathy, 03 medical and health sciences, chemistry.chemical_compound, Mice, 0302 clinical medicine, Soluble Guanylyl Cyclase, Fibrosis, medicine, Renal fibrosis, Animals, Humans, Tissue Distribution, Endothelial dysfunction, Antihypertensive Agents, Arteries, medicine.disease, Rats, Vasodilation, Disease Models, Animal, Proteinuria, 030104 developmental biology, medicine.anatomical_structure, Cytokine, HEK293 Cells, Pyrimidines, chemistry, Molecular Medicine, Pyrazoles, Endothelium, Vascular, medicine.symptom, Signal Transduction

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36c4901b890abc311faa878fa692a045Test
https://pubmed.ncbi.nlm.nih.gov/29643251Test

8

The Soluble Guanylate Cyclase Stimulator IW-1701 Enhances Nitric Oxide-Mediated Relaxation of Human Lower Esophageal Sphincter ex vivo

المؤلفون: Ines A. Silva, Mark G. Currie, G. Todd Milne, Daniel P. Zimmer, Yueh-Tyng Chien

المصدر: Gastroenterology. 152:S699

مصطلحات موضوعية: 0301 basic medicine, medicine.medical_specialty, Hepatology, Chemistry, Gastroenterology, 030204 cardiovascular system & hematology, Soluble Guanylate Cyclase Stimulator, Nitric oxide, 03 medical and health sciences, chemistry.chemical_compound, 030104 developmental biology, 0302 clinical medicine, Endocrinology, Internal medicine, medicine, Esophageal sphincter, Biophysics, Relaxation (physics), Ex vivo

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::a5956805e00588dc3283b11408b144acTest
https://doi.org/10.1016/s0016-5085Test(17)32443-5

9

Discovery and Characterization of a Potent Interleukin-6 Binding Peptide with Neutralizing Activity In Vivo

المصدر: PLoS ONE
PLoS ONE, Vol 10, Iss 11, p e0141330 (2015)

مصطلحات موضوعية: Male, Models, Molecular, STAT3 Transcription Factor, Protein Conformation, medicine.drug_class, Molecular Sequence Data, lcsh:Medicine, Peptide, Pharmacology, Monoclonal antibody, Rats, Sprague-Dawley, Mice, Random Allocation, Structure-Activity Relationship, chemistry.chemical_compound, Peptide Library, Peptide synthesis, medicine, Animals, Humans, Amino Acid Sequence, Serum amyloid A, lcsh:Science, Interleukin 6, Peptide library, chemistry.chemical_classification, Mice, Inbred BALB C, Mice, Inbred ICR, Hybridomas, Multidisciplinary, biology, Interleukin-6, lcsh:R, Interleukin, U937 Cells, Receptors, Interleukin-6, Molecular biology, Recombinant Proteins, Rats, Macaca fascicularis, chemistry, Drug Design, biology.protein, PEGylation, lcsh:Q, Peptides, Half-Life, Research Article

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bae3bfde1874cee8f005df8a8c4261c7Test
https://doi.org/10.1371/journal.pone.0141330Test

10

Fatty acid amide hydrolase (FAAH) inhibition reduces L-3,4-dihydroxyphenylalanine-induced hyperactivity in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-lesioned non-human primate model of Parkinson's disease

المؤلفون: Philippe Huot, G. Todd Milne, Kristine Sykes, Jonathan M. Brotchie, Susan H. Fox, Wilmin Bartolini, James Wakefield, James Philip Pearson, Tom H. Johnston

المصدر: The Journal of pharmacology and experimental therapeutics. 336(2)

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::113a70bb3d0709f10755c85148a74d69Test
https://pubmed.ncbi.nlm.nih.gov/20966038Test

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