يعرض 1 - 10 نتائج من 165 نتيجة بحث عن '"Orexin-A"', وقت الاستعلام: 0.65s تنقيح النتائج
  1. 1
    Effect of Liver Cirrhosis on the Pharmacokinetics, Metabolism, and Tolerability of Daridorexant, A Novel Dual Orexin Receptor Antagonist

    المؤلفون: Clemens Muehlan, Urs Duthaler, Stephane Delahaye, Jasper Dingemanse, Benjamin Berger, Stephan Krähenbühl, Giancarlo Sabattini

    المصدر: Clinical Pharmacokinetics. 60:1349-1360

    مصطلحات موضوعية: Liver Cirrhosis, medicine.medical_specialty, Pyrrolidines, Cirrhosis, Metabolite, 030226 pharmacology & pharmacy, Gastroenterology, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Pharmacokinetics, Internal medicine, medicine, Humans, Pharmacology (medical), Adverse effect, Pharmacology, Volume of distribution, business.industry, Liver Diseases, Imidazoles, Antagonist, medicine.disease, Orexin receptor, chemistry, Tolerability, Area Under Curve, Orexin Receptor Antagonists, business, 030217 neurology & neurosurgery

    الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3436174cb8e7e7c5ce550a461a31e69Test
    https://doi.org/10.1007/s40262-021-01028-8Test


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  2. 2
    Neuropeptide S-initiated sequential cascade mediated by OX1, NK1, mGlu5 and CB1 receptors: a pivotal role in stress-induced analgesia

    المؤلفون: Girolamo Calo, Remo Guerrini, Yu-Chun Chiu, Chia Chun Hor, Lih-Chu Chiou, Ming Tatt Lee, Hsin Jung Lee, Yu-Ting Chiu

    المصدر: Journal of Biomedical Science, Vol 27, Iss 1, Pp 1-15 (2020)
    Journal of Biomedical Science

    مصطلحات موضوعية: Male, 0301 basic medicine, Cannabinoid receptor, Endocrinology, Diabetes and Metabolism, Clinical Biochemistry, lcsh:Medicine, Substance P, Pharmacology, Mice, chemistry.chemical_compound, 0302 clinical medicine, Receptor, Cannabinoid, CB1, Neuropeptide S, Orexin Receptors, Pharmacology (medical), Chemistry, Glutamate receptor, Neuropeptide S, Orexin, Substance P, Metabotropic glutamate receptor, Endocannabinoid, Periaqueductal gray, General Medicine, CB1, Metabotropic Glutamate 5, Endocannabinoid system, Endocannabinoid, Metabotropic glutamate receptor, Orexin, Periaqueductal gray, Animals, Neuropeptides, Receptor, Metabotropic Glutamate 5, Stress, Psychological, Ventral Thalamic Nuclei, Analgesia, Receptor, Stress, NO, 03 medical and health sciences, mental disorders, Cannabinoid, Molecular Biology, Research, Biochemistry (medical), lcsh:R, Cell Biology, Blockade, 030104 developmental biology, nervous system, Psychological, 030217 neurology & neurosurgery

    الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2431a8326753b1661e3a5d82baba6b65Test
    https://doaj.org/article/53f537b86a584716bdf814fb935a0b18Test


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  3. 3
    Integrated Screening of Effective Anti-Insomnia Fractions of Zhi-Zi-Hou-Po Decoction via Drosophila melanogaster and Network Pharmacology Analysis of the Underlying Pharmacodynamic Material and Mechanism

    المؤلفون: Yijia Cao, Tiange Yang, Yu Sun, Chenning Zhang, Yuxia Qu, Yikun Sun, Shiting Ni, Tianyi Li, Hao Wu, Renyun Zhao, Runhua Liu

    المصدر: ACS Omega, Vol 6, Iss 13, Pp 9176-9187 (2021)

    مصطلحات موضوعية: Honokiol, biology, GABAA receptor, General Chemical Engineering, Homovanillic acid, General Chemistry, Pharmacology, biology.organism_classification, Magnolol, Orexin receptor, Chemistry, chemistry.chemical_compound, Monoamine neurotransmitter, chemistry, Melanogaster, Drosophila melanogaster, QD1-999

    الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d648d43aeeef00e9a0f26d77d793ebbTest
    https://doi.org/10.1021/acsomega.1c00445Test


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  4. 4
    Magnetic Resonance Spectroscopy in the Ventral Tegmental Area Distinguishes Responders to Suvorexant Prior to Treatment: A 4-Week Prospective Cohort Study

    المؤلفون: Muneto Izuhara, Shoko Miura, Koji Otsuki, Michiharu Nagahama, Maiko Hayashida, Sadayuki Hashioka, Hiroya Asou, Hajime Kitagaki, Masatoshi Inagaki

    المصدر: Frontiers in Psychiatry, Vol 12 (2021)
    Frontiers in Psychiatry

    مصطلحات موضوعية: glia, insomnia, ventral tegmental area, RC435-571, Pharmacology, Creatine, chemistry.chemical_compound, mental disorders, Medicine, Premovement neuronal activity, Original Research, Psychiatry, psychiatric patients, business.industry, Dopaminergic, Suvorexant, Antagonist, suvorexant, magnetic resonance spectroscopy, Orexin receptor, Orexin, Ventral tegmental area, Psychiatry and Mental health, medicine.anatomical_structure, chemistry, nervous system, orexin, business, psychological phenomena and processes

    الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04734ffe5c6f2011c00194c7a16c49a2Test
    https://www.frontiersin.org/articles/10.3389/fpsyt.2021.714376/fullTest


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  5. 5
    Effect of gastric pH and of a moderate CYP3A4 inducer on the pharmacokinetics of daridorexant, a dual orexin receptor antagonist

    المؤلفون: Martine Gehin, Jolanta Wierdak, Jasper Dingemanse, Giancarlo Sabattini, Patricia N. Sidharta

    المصدر: British journal of clinical pharmacologyREFERENCES. 88(2)

    مصطلحات موضوعية: Male, Efavirenz, Pyrrolidines, Cmax, Pharmacology, chemistry.chemical_compound, Pharmacokinetics, Medicine, Cytochrome P-450 CYP3A, Humans, Pharmacology (medical), Drug Interactions, Prospective Studies, CYP3A4, business.industry, Antagonist, Imidazoles, Cytochrome P-450 CYP3A Inducers, Hydrogen-Ion Concentration, Famotidine, Orexin receptor, Tolerability, chemistry, Area Under Curve, Orexin Receptor Antagonists, business, medicine.drug

    الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43f316bb390a8f0097914f56d1a5ca2dTest
    https://pubmed.ncbi.nlm.nih.gov/34371524Test


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  6. 6
    Disposition and Metabolism of [14C]Lemborexant in Healthy Human Subjects and Characterization of Its Circulating Metabolites

    المؤلفون: Shoji Asakura, Michiyuki Suzuki, Kazutomi Kusano, Takashi Ueno, Tomomi Ishida, Carsten T. Beuckmann, Jagadeesh Aluri, Takaaki Kameyama

    المصدر: Drug Metabolism and Disposition. 49:31-38

    مصطلحات موضوعية: Pharmacology, business.industry, Metabolite, Glucuronidation, Pharmaceutical Science, Urine, 030226 pharmacology & pharmacy, Orexin receptor, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Pharmacokinetics, chemistry, Oral administration, 030220 oncology & carcinogenesis, Medicine, business, Drug metabolism, ADME

    الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::310105c91488bc39459672158f368b02Test
    https://doi.org/10.1124/dmd.120.000229Test


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  7. 7
    Oxadiazole Derivatives as Dual Orexin Receptor Antagonists: Synthesis, Structure–Activity Relationships, and Sleep‐Promoting Properties in Rats

    المؤلفون: John Gatfield, Catherine Roch, Thierry Sifferlen, Jodi T. Williams, Alexander Treiber, Christoph Boss, Martin Bolli, Christine Brotschi, Bibia Heidmann, Francois Jenck

    المصدر: ChemMedChem. 14:1257-1270

    مصطلحات موضوعية: Oxadiazole, Pharmacology, 01 natural sciences, Biochemistry, Inhibitory Concentration 50, Structure-Activity Relationship, chemistry.chemical_compound, Dogs, Orexin Receptors, Drug Discovery, Animals, Cytochrome P-450 CYP3A, Humans, General Pharmacology, Toxicology and Pharmaceutics, Receptor, Oxadiazoles, CYP3A4, 010405 organic chemistry, Organic Chemistry, Suvorexant, Antagonist, Azepines, Triazoles, Orexin receptor, Rats, 0104 chemical sciences, Orexin, 010404 medicinal & biomolecular chemistry, chemistry, Molecular Medicine, Orexin Receptor Antagonists, Wakefulness, Sleep, Half-Life

    الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b115f7c0f955cf770604ab0fdaa3d44Test
    https://doi.org/10.1002/cmdc.201900242Test


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  8. 8
    Interaction potential of the dual orexin receptor antagonist ACT-541468 with CYP3A4 and food: results from two interaction studies

    المؤلفون: Marie-Laure Boof, Jasper Dingemanse, Mike Ufer, Abir Alatrach

    المصدر: European Journal of Clinical Pharmacology. 75:195-205

    مصطلحات موضوعية: Adult, Male, Midazolam, Metabolite, Cmax, Bioequivalence, Pharmacology, 030226 pharmacology & pharmacy, Eating, Food-Drug Interactions, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Pharmacokinetics, medicine, Cytochrome P-450 CYP3A, Humans, Pharmacology (medical), 030212 general & internal medicine, Diltiazem, Cross-Over Studies, business.industry, Antagonist, General Medicine, Orexin receptor, chemistry, Area Under Curve, Cytochrome P-450 CYP3A Inhibitors, Female, Orexin Receptor Antagonists, business, medicine.drug

    الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a62d4b96d7f41b62cbfeca73b623bffTest
    https://doi.org/10.1007/s00228-018-2559-5Test


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  9. 9
    Relationship between the fluorescence intensity of rhodamine-labeled orexin A and the calcium responses in cortical neurons: An in vivo two-photon calcium imaging study

    المؤلفون: Hiromasa Tsuda, Morio Tonogi, Satoshi Fujita, Saori Ohtani, Masayuki Kobayashi, Koki Hasegawa

    المصدر: Journal of Pharmacological Sciences, Vol 138, Iss 1, Pp 76-82 (2018)

    مصطلحات موضوعية: 0301 basic medicine, Receptor expression, chemistry.chemical_element, Mice, Transgenic, Calcium, Fluorescence, Rhodamine, 03 medical and health sciences, Orexin-A, chemistry.chemical_compound, 0302 clinical medicine, Calcium imaging, Orexin Receptors, medicine, Animals, Cerebral Cortex, Neurons, Pharmacology, Orexins, Rhodamines, Chemistry, lcsh:RM1-950, Orexin receptor, Molecular Imaging, Orexin, lcsh:Therapeutics. Pharmacology, 030104 developmental biology, medicine.anatomical_structure, nervous system, Cerebral cortex, Biophysics, Molecular Medicine, 030217 neurology & neurosurgery, Protein Binding

    الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8b010e24172eba31e557fab79a24454Test
    https://doi.org/10.1016/j.jphs.2018.09.005Test


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  10. 10
    Azulene-based compounds for targeting orexin receptors

    المؤلفون: Ainoleena Turku, Henri Xhaard, Erik A.A. Wallén, Jyrki P. Kukkonen, Jari Yli-Kauhaluoma, Teppo O. Leino

    المساهمون: Faculty of Pharmacy, Pharmaceutical Design and Discovery group, Division of Pharmaceutical Chemistry and Technology, Drug Research Program, Jari Yli-Kauhaluoma / Principal Investigator, Jyrki Kukkonen / Principal Investigator, Veterinary Biochemistry and Cell Biology, Veterinary Biosciences, Departments of Faculty of Veterinary Medicine, Faculty of Veterinary Medicine, Department of Physiology, Medicum, Henri Xhaard / Principal Investigator, Erik Wallen / Principal Investigator

    المصدر: European Journal of Medicinal Chemistry. 157:88-100

    مصطلحات موضوعية: 0301 basic medicine, Agonist, medicine.drug_class, Stereochemistry, 116 Chemical sciences, SIGNAL-TRANSDUCTION, 01 natural sciences, Azulenes, Structure-Activity Relationship, 03 medical and health sciences, chemistry.chemical_compound, PROTEIN-COUPLED RECEPTORS, Orexin Receptors, Drug Discovery, KINASE, medicine, Humans, Azulene, OX1, Receptor, Pharmacology, Orexin receptor, CA2+ INFLUX, Dose-Response Relationship, Drug, Molecular Structure, DERIVATIVES, 010405 organic chemistry, Organic Chemistry, Antagonist, PEPTIDES, Long-term potentiation, HAMSTER OVARY CELLS, General Medicine, Potentiator, 3. Good health, 0104 chemical sciences, Orexin, Sleep-wake regulation, 030104 developmental biology, chemistry, 317 Pharmacy, LIGANDS, Signal transduction, INHIBITORS

    الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::daf1f88ce88287ada5393d1c3286c86fTest
    https://doi.org/10.1016/j.ejmech.2018.07.040Test


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