Structure and Function Relationships of a Redox-Sensor Protein, Heme-Regulated Phosphodiesterase
العنوان: | Structure and Function Relationships of a Redox-Sensor Protein, Heme-Regulated Phosphodiesterase |
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المؤلفون: | Hirofumi Kurokawa, Yukie Sasakura, Satoshi Hirata, Sue Taguchi, Jotaro Igarashi, M. Watanabe, Ikuko Sagami, Toru Shimizu, Tokiko Suzuki-Yoshimura |
المصدر: | Seibutsu Butsuri. 45:84-89 |
بيانات النشر: | Biophysical Society of Japan, 2005. |
سنة النشر: | 2005 |
مصطلحات موضوعية: | chemistry.chemical_classification, Phosphodiesterase, Crystal structure, Redox sensor, Biology, medicine.disease_cause, Structure and function, chemistry.chemical_compound, Enzyme, Biochemistry, chemistry, PAS domain, medicine, Heme, Escherichia coli |
الوصف: | Heme-regulated phosphodiesterase from Escherichia coli (Ec DOS) is a novel PAS heme-sensor enzyme. Ec DOS is active in the Fe2+ heme-bound form, whereas it is inactive in the Fe3+ heme-bound form. To elucidate the mechanism of the redox-dependent heme-regulated catalysis, we examined spectroscopic and functional characters of site-directed and deletion mutant proteins. We also determined crystal structures of the wild type enzyme under various conditions. In this review, we summarized findings about heme-sensor proteins, PAS domain and phosphodiesterase in general and structure and function relationships of Ec DOS specifically. |
تدمد: | 1347-4219 0582-4052 |
الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_________::785eb9800f97ac9ff17b794c2f588217Test https://doi.org/10.2142/biophys.45.84Test |
حقوق: | OPEN |
رقم الانضمام: | edsair.doi...........785eb9800f97ac9ff17b794c2f588217 |
قاعدة البيانات: | OpenAIRE |
تدمد: | 13474219 05824052 |
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