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1دورية أكاديمية
المصدر: ACS Central Science, Vol 2, Iss 11, Pp 867-871 (2016)
وصف الملف: electronic resource
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2
المؤلفون: Scott D. Thiel, Paul V. Marshall, Yue Meng, James P. S. Walsh, Zeynep Alptekin, Dean Smith
المصدر: Chemistry of Materials. 33:9601-9607
مصطلحات موضوعية: Transition metal carbides, Range (particle radiation), Materials science, Cementite, General Chemical Engineering, Metallurgy, chemistry.chemical_element, General Chemistry, Carbide, chemistry.chemical_compound, chemistry, High pressure, Heat shield, Materials Chemistry, Cobalt
الوصف: Transition metal carbides find use in a wide range of advanced high-resilience applications including high-strength steels, heat shields, and deep-earth drills. However, carbides of the mid-to-late...
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::e681eafd68e320f6fc91e78d0e1dbfaaTest
https://doi.org/10.1021/acs.chemmater.1c03092Test -
3
المؤلفون: Robert W. Pitz, Garrett J. Marshall, Patrick S. Walsh
المصدر: Proceedings of the Combustion Institute. 38:1833-1841
مصطلحات موضوعية: Quenching (fluorescence), Number density, Hydrogen, Mechanical Engineering, General Chemical Engineering, Radical, Analytical chemistry, chemistry.chemical_element, Kinetic energy, symbols.namesake, Experimental uncertainty analysis, chemistry, symbols, Physical and Theoretical Chemistry, Laser-induced fluorescence, Raman scattering
الوصف: Quantitative O-atom profiles are measured for the first time in tubular flames and used to assess the performance of chemical kinetic mechanisms in tubular flame simulations. Atomic oxygen is measured via femtosecond, Two-Photon Laser Induced Fluorescence (fs-TPLIF) to avoid photolytic interference. The fs-TPLIF signal is corrected for collisional quenching from major species concentrations measured by Raman scattering. Temperature-dependent quenching rate in the form of T − 0.5 for H2O is applied to better represent the actual physics, and all simulations are found to agree with this method. Atomic oxygen is reported in H2/O2 flames diluted with N2 or CO2 at 200 and 400 s−1 stretch rates. The oxygen radical data is compared to predictions using three different, detailed chemical kinetic mechanisms. Predictions of profile shape vary slightly, but the peak O-atom number density is calculated within experimental uncertainty by eachmechanism.
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::c019e7eb658b359aa847f5c39f9cc514Test
https://doi.org/10.1016/j.proci.2020.08.043Test -
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المؤلفون: Alison B. Altman, James M. Rondinelli, Chris J. Pickard, James P. S. Walsh, Danna E. Freedman, Yue Meng, Steven D. Jacobsen, Nathan Z. Koocher, Alexandra D. Tamerius
المصدر: Journal of the American Chemical Society. 143:214-222
مصطلحات موضوعية: Chemistry, Ab initio, chemistry.chemical_element, General Chemistry, Electronic structure, 010402 general chemistry, 01 natural sciences, Biochemistry, Catalysis, Diamond anvil cell, 0104 chemical sciences, Bismuth, Colloid and Surface Chemistry, Chemical physics, Valence electron, Realization (systems), Topology (chemistry), Ambient pressure
الوصف: Incorporating bismuth, the heaviest element stable to radioactive decay, into new materials enables the creation of emergent properties such as permanent magnetism, superconductivity, and nontrivial topology. Understanding the factors that drive Bi reactivity is critical for the realization of these properties. Using pressure as a tunable synthetic vector, we can access unexplored regions of phase space to foster reactivity between elements that do not react under ambient conditions. Furthermore, combining computational and experimental methods for materials discovery at high-pressures provides broader insight into the thermodynamic landscape than can be achieved through experiment alone, informing our understanding of the dominant chemical factors governing structure formation. Herein, we report our combined computational and experimental exploration of the Mo-Bi system, for which no binary intermetallic structures were previously known. Using the ab initio random structure searching (AIRSS) approach, we identified multiple synthetic targets between 0-50 GPa. High-pressure in situ powder X-ray diffraction experiments performed in diamond anvil cells confirmed that Mo-Bi mixtures exhibit rich chemistry upon the application of pressure, including experimental realization of the computationally predicted CuAl2-type MoBi2 structure at 35.8(5) GPa. Electronic structure and phonon dispersion calculations on MoBi2 revealed a correlation between valence electron count and bonding in high-pressure transition metal-Bi structures as well as identified two dynamically stable ambient pressure polymorphs. Our study demonstrates the power of the combined computational-experimental approach in capturing high-pressure reactivity for efficient materials discovery.
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::144400fd9f9ff5825e6506493e4749c6Test
https://doi.org/10.1021/jacs.0c09419Test -
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المصدر: Weed Technology. 35:628-631
مصطلحات موضوعية: Irrigation, Bentazon, Randomized block design, 04 agricultural and veterinary sciences, Plant Science, Biology, Weed control, biology.organism_classification, 01 natural sciences, 010104 statistics & probability, Horticulture, chemistry.chemical_compound, chemistry, Pinto bean, 040103 agronomy & agriculture, 0401 agriculture, forestry, and fisheries, Dimethenamid, Seeding, 0101 mathematics, Weed, Agronomy and Crop Science
الوصف: Field experiments were conducted in 2016 and 2017 to evaluate the effects of seeding rate and herbicide programs on weed control and pinto bean yield under irrigation. The experiments comprised a 5 × 5 factorial randomized complete block design with five replications. The weed control treatments comprised a nontreated control, hand-weeded control, EPTC + ethalfluralin PRE, EPTC + ethalfluralin PRE followed by (fb) dimethenamid-P POST at V1, and EPTC + ethalfluralin PRE fb bentazon/imazamox POST. There were five seeding rates ranging from 247,000 to 494,000 seeds ha–1 planted in 19-cm rows. Weed biomass was reduced by 6 kg ha–1 with every additional 1,000 seeds ha–1. EPTC plus ethalfluralin fb either dimethenamid-P or bentazon plus imazamox reduced weed biomass by at least 29% compared to the nontreated control. There was a significant effect of weed control treatment on pinto bean yield (P = 0.0004). However, there was no significant seeding rate (P = 0.42) or seeding rate–by–weed control interaction effect on pinto bean yield (P = 0.38). Pinto bean yield ranged from 3,080 kg ha–1 in the nontreated control to 4,740 kg ha–1 hand-weeded treatment. Increased seeding rate in narrow rows is a cultural practice that can improve weed control in pinto bean but may not necessarily increase yield.
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::0321931a080d184cc8555bad7a6b441fTest
https://doi.org/10.1017/wet.2020.137Test -
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المؤلفون: Stina Syvänen, Greta Hultqvist, Frank S. Walsh, Tobias Gustavsson, J Lynn Rutkowski, Dag Sehlin, Pawel Stocki
المصدر: The FASEB Journal. 34:13272-13283
مصطلحات موضوعية: 0301 basic medicine, Genetically modified mouse, Recombinant Fusion Proteins, Transferrin receptor, Antibodies, Monoclonal, Humanized, Biochemistry, receptor mediated transcytosis, Pharmaceutical Sciences, Mice, 03 medical and health sciences, Drug Delivery Systems, 0302 clinical medicine, Antigens, CD, antibody, Receptors, Transferrin, Parenchyma, Genetics, medicine, Animals, Humans, Distribution (pharmacology), Bapineuzumab, blood-brain barrier (BBB), positron emission tomography (PET), Molecular Biology, Biological Products, biology, Chemistry, amyloid-β (Aβ), Farmaceutiska vetenskaper, Molecular biology, Immunoglobulin Fc Fragments, Mice, Inbred C57BL, Thromboxane B2, 030104 developmental biology, Transcytosis, Blood-Brain Barrier, Alzheimer's disease (AD), biology.protein, lipids (amino acids, peptides, and proteins), Antibody, 030217 neurology & neurosurgery, Ex vivo, circulatory and respiratory physiology, Biotechnology, medicine.drug
الوصف: Transferrin receptor 1 (TfR1) mediated transcytosis is an attractive strategy to enhance brain uptake of protein drugs, but translation remains a challenge. Here, a single domain shark antibody VNAR fragment (TXB2) with similar affinity to murine and human TfR1 was used to shuttle protein cargo into the brain. TXB2 was fused to a human IgG1 Fc domain (hFc) or to the amyloid-β (Aβ) antibody bapineuzumab (Bapi). TXB2-hFc displayed 20-fold higher brain concentrations compared with a control VNAR-hFc at 18 hours post-injection in wt mice. At the same time point, brain concentrations of Bapi-TXB2 was threefold higher than Bapi. In transgenic mice overexpressing human Aβ, the brain-to-blood concentration ratio increased with time due to interaction with intracerebral Aβ deposits. The relatively stable threefold difference between Bapi-TXB2 and Bapi was observed for up to 6 days after injection. PET imaging and ex vivo autoradiography revealed more parenchymal distribution of Bapi-TXB2 compared with Bapi. In conclusion, the TXB2 VNAR shuttle markedly increased brain uptake of protein cargo and increased brain concentrations of the Aβ binding antibody Bapi.
وصف الملف: application/pdf
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::096b68c6da4c11e14820fc68570f777aTest
https://doi.org/10.1096/fj.202000610rrTest -
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المؤلفون: Olga S. Walsh
المصدر: Crops & Soils. 52:10-16
مصطلحات موضوعية: Wheat grain, geography, Yield (engineering), Human fertilization, geography.geographical_feature_category, Agronomy, Chemistry, Potassium, Spring (hydrology), chemistry.chemical_element, General Medicine, Nitrogen
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::d33ebae99cbadb7e7922b4ca71b82646Test
https://doi.org/10.2134/cs2019.52.0605Test -
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المؤلفون: H. I. Fried, D. J. Sales, Morgan R. Smith, S. E. McGrath, C. R. Keelan, E. A. Murray, K. A. Eldridge, Morgan M. Steffen, Naomi E. Gilbert, G. H. Alvarez, C. M. Modolo, S. M. Polisetti, L. R. Kohler, M. A. Coceano, G. Reynoso, M. T. Harris, E. S. Walsh, C. P. Holmes
المصدر: Water Science and Technology. 80:675-684
مصطلحات موضوعية: Environmental Engineering, Nitrogen, chemistry.chemical_element, Freshwater ecosystem, Actinobacteria, 03 medical and health sciences, chemistry.chemical_compound, Nutrient, Nitrate, RNA, Ribosomal, 16S, Proteobacteria, 030304 developmental biology, Water Science and Technology, 0303 health sciences, Bacteria, biology, 030306 microbiology, Ecology, Phosphorus, Community structure, biology.organism_classification, Lakes, chemistry, Microbial population biology, Environmental science
الوصف: Microbial processes are critical to the function of freshwater ecosystems, yet we still do not fully understand the factors that shape freshwater microbial communities. Furthermore, freshwater ecosystems are particularly susceptible to effects of environmental change, including influx of exogenous nutrients such as nitrogen and phosphorus. To evaluate the impact of nitrogen loading on the microbial community structure of shallow freshwater lakes, water samples collected from Lake Shenandoah (Virginia, USA) were incubated with two concentrations of either ammonium, nitrate, or urea as a nitrogen source. The potential impact of these nitrogen compounds on the bacterial community structure was assessed via 16S rRNA amplicon sequencing. At the phylum level, the dominant taxa in Lake Shenandoah were comprised of Actinobacteria and Proteobacteria, which were not affected by exposure to the various nitrogen treatments. Overall, there was not a significant shift in the diversity of the bacterial community of Lake Shenandoah with the addition of nitrogen sources, indicating this shallow system may be constrained by other environmental factors.
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2760359cce7b6e9d8eb8758ad066ec66Test
https://doi.org/10.2166/wst.2019.311Test -
9دورية أكاديمية
المؤلفون: Abiy Yenesew, Hannington Twinomuhwezi, Jacques M. Kabaru, Hoseah M. Akala, Bernard T. Kiremire, Matthias Heydenreich, Martin G. Peter, Fredrick L. Eyase, Norman C. Waters, Douglas S. Walsh
المصدر: Bulletin of the Chemical Society of Ethiopia, Vol 23, Iss 3, Pp 409-414 (2009)
مصطلحات موضوعية: Derris trifoliata, Leguminosae, Flavanone, (S)-Lupinifolin 4´-methyl ether, Lupinifolin, Antiplasmodial, Rotenoid, Larvicide, Aedes aegypti, Chemistry, QD1-999
الوصف: From the dichloromethane-methanol (1:1) extract of the seed pods of Derris trifoliata, a new flavanone derivative (S)-lupinifolin 4´-methyl ether was isolated. In addition, the known flavonoids lupinifolin and rotenone were identified. The structures were determined on the basis of spectroscopic evidence. Lupinfolin showed moderate in vitro antiplasmodial activity against the D6 (chloroquine-sensitive) and W2 (chloroquine-resistant) strains of Plasmodium falciparum. The different parts of this plant showed larvicidal activities against Aedes aegypti and rotenoids were identified as the active principles.
وصف الملف: electronic resource
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المؤلفون: Linda Heier, Jeff M. Michalski, Leanne Embry, Yimei Li, Amar Gajjar, Karin S. Walsh, Kyle S. Smith, Alok Jaju, Roger J. Packer, Sarah Leary, James M. Olson, Maryam Fouladi, Jennifer Hadley, Catherine A. Billups, Eugene Hwang, Paul A. Northcott, Peter C. Burger, Ian F. Pollack, Yuanyuan Han, Rahul Kumar
المصدر: JAMA Oncol
مصطلحات موضوعية: Oncology, Cancer Research, Vincristine, medicine.medical_specialty, Randomization, Subgroup analysis, law.invention, chemistry.chemical_compound, Randomized controlled trial, law, Internal medicine, medicine, Biomarkers, Tumor, Humans, Cerebellar Neoplasms, Isotretinoin, Original Investigation, Medulloblastoma, business.industry, Gene Expression Profiling, medicine.disease, Carboplatin, Clinical trial, chemistry, business, medicine.drug
الوصف: Importance Brain tumors are the leading cause of disease-related death in children. Medulloblastoma is the most common malignant embryonal brain tumor, and strategies to increase survival are needed. Objective To evaluate therapy intensification with carboplatin as a radiosensitizer and isotretinoin as a proapoptotic agent in children with high-risk medulloblastoma in a randomized clinical trial and, with a correlative biology study, facilitate planned subgroup analysis according to World Health Organization consensus molecular subgroups of medulloblastoma. Design, Setting, and Participants A randomized clinical phase 3 trial was conducted from March 2007 to September 2018. Analysis was completed in September 2020. Patients aged 3 to 21 years with newly diagnosed high-risk medulloblastoma from Children’s Oncology Group institutions within the US, Canada, Australia, and New Zealand were included. High-risk features included metastasis, residual disease, or diffuse anaplasia. Interventions Patients were randomized to receive 36-Gy craniospinal radiation therapy and weekly vincristine with or without daily carboplatin followed by 6 cycles of maintenance chemotherapy with cisplatin, cyclophosphamide, and vincristine with or without 12 cycles of isotretinoin during and following maintenance. Main Outcomes and Measures The primary clinical trial end point was event-free survival, using the log-rank test to compare arms. The primary biology study end point was molecular subgroup classification by DNA methylation array. Results Of 294 patients with medulloblastoma, 261 were evaluable after central radiologic and pathologic review; median age, 8.6 years (range, 3.3-21.2); 183 (70%) male; 189 (72%) with metastatic disease; 58 (22%) with diffuse anaplasia; and 14 (5%) with greater than 1.5-cm2residual disease. For all participants, the 5-year event-free survival was 62.9% (95% CI, 55.6%-70.2%) and overall survival was 73.4% (95% CI, 66.7%-80.1%). Isotretinoin randomization was closed early owing to futility. Five-year event-free survival was 66.4% (95% CI, 56.4%-76.4%) with carboplatin vs 59.2% (95% CI, 48.8%-69.6%) without carboplatin (P = .11), with the effect exclusively observed in group 3 subgroup patients: 73.2% (95% CI, 56.9%-89.5%) with carboplatin vs 53.7% (95% CI, 35.3%-72.1%) without (P = .047). Five-year overall survival differed by molecular subgroup (P = .006): WNT pathway activated, 100% (95% CI, 100%-100%); SHH pathway activated, 53.6% (95% CI, 33.0%-74.2%); group 3, 73.7% (95% CI, 61.9%-85.5%); and group 4, 76.9% (95% CI, 67.3%-86.5%). Conclusions and Relevance In this randomized clinical trial, therapy intensification with carboplatin improved event-free survival by 19% at 5 years for children with high-risk group 3 medulloblastoma. These findings further support the value of an integrated clinical and molecular risk stratification for medulloblastoma. Trial Registration ClinicalTrials.gov Identifier:NCT00392327
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6450a775c0a26cfad724e1e171bf7cb5Test
https://europepmc.org/articles/PMC8299367Test/
النص الكامل