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41Synthetic and Naturally Occurring Heterocyclic Anticancer Compounds with Multiple Biological Targets
المؤلفون: Patrick O. Sakyi, Dorcas Osei-Safo, Ivan Addae-Mensah, Richard Amewu
المصدر: Molecules, Vol 26, Iss 7134, p 7134 (2021)
Moleculesمصطلحات موضوعية: Vascular Endothelial Growth Factor A, Angiogenesis, Pharmaceutical Science, Antineoplastic Agents, Review, multiple biological targets, Fibroblast growth factor, Analytical Chemistry, angiogenesis, chemistry.chemical_compound, QD241-441, vascularization, heterocyclic compounds, Epidermal growth factor, Neoplasms, homeostasis, Drug Discovery, Humans, metastasis, Physical and Theoretical Chemistry, Thymidine phosphorylase, Platelet-Derived Growth Factor, Biological Products, Thymidine Phosphorylase, Natural product, Epidermal Growth Factor, biology, Chemistry, Organic Chemistry, apoptosis, Receptors, Neuropeptide Y, Fibroblast Growth Factors, Vascular endothelial growth factor, Chemistry (miscellaneous), Cancer cell, biology.protein, Cancer research, Molecular Medicine, Platelet-derived growth factor receptor
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e829929adb8cc0d2d025e52c50b40f68Test
https://doi.org/10.3390/molecules26237134Test -
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المؤلفون: Yong Zhou, Fu Chen, Yong Wang, Keyu Yang, Mingyang Shen
المصدر: Life sciences. 262
مصطلحات موضوعية: 0301 basic medicine, Male, medicine.medical_specialty, 030226 pharmacology & pharmacy, General Biochemistry, Genetics and Molecular Biology, Rats, Sprague-Dawley, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Non-alcoholic Fatty Liver Disease, Internal medicine, mental disorders, medicine, Extracellular, Animals, Neuropeptide Y, General Pharmacology, Toxicology and Pharmaceutics, Neurotransmitter, Receptor, Protein kinase A, Cholesterol, Fatty liver, General Medicine, Neuropeptide Y receptor, medicine.disease, humanities, Rats, Receptors, Neuropeptide Y, 030104 developmental biology, Endocrinology, chemistry, Hepatocytes, Hydroxymethylglutaryl CoA Reductases, Signal transduction, Sterol Regulatory Element Binding Protein 2
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a010d778f8a6741f9bc2b20cc11ebe4Test
https://pubmed.ncbi.nlm.nih.gov/32976883Test -
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المؤلفون: Naomi Yonemochi, Tomohiro Kamata, John L. Waddington, Masahiro Shibasaki, Hiroko Ikeda, Junzo Kamei, Daiki Ueda
المصدر: British journal of pharmacologyREFERENCES. 178(3)
مصطلحات موضوعية: 0301 basic medicine, Agonist, medicine.medical_specialty, medicine.drug_class, Neuropeptide, AMPA receptor, Streptozocin, Diabetes Mellitus, Experimental, 03 medical and health sciences, chemistry.chemical_compound, Glutamatergic, Mice, 0302 clinical medicine, Internal medicine, medicine, Animals, Neuropeptide Y, Social Behavior, Pharmacology, business.industry, Novelty, Neuropeptide Y receptor, Receptors, Neuropeptide Y, 030104 developmental biology, Endocrinology, chemistry, BIIE-0246, NBQX, business, 030217 neurology & neurosurgery
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e08343a1fd8e398ccb0ab00ee850e36Test
https://pubmed.ncbi.nlm.nih.gov/35971963Test -
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المؤلفون: Ryan A. Lafferty, Peter R. Flatt, Neil Tanday, Nigel Irwin
المصدر: Metabolism: clinical and experimental. 111
مصطلحات موضوعية: 0301 basic medicine, Male, medicine.medical_specialty, Endocrinology, Diabetes and Metabolism, media_common.quotation_subject, Dipeptidyl Peptidase 4, Neuropeptide, 030209 endocrinology & metabolism, Peptide, Glucagon, Cell Line, 03 medical and health sciences, Islets of Langerhans, Mice, 0302 clinical medicine, Endocrinology, Internal medicine, Insulin-Secreting Cells, medicine, Animals, Humans, Peptide YY, media_common, chemistry.chemical_classification, geography, geography.geographical_feature_category, biology, Chemistry, Lamprey, digestive, oral, and skin physiology, Appetite, biology.organism_classification, Islet, Receptors, Neuropeptide Y, 030104 developmental biology, Anorectic, human activities, hormones, hormone substitutes, and hormone antagonists
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bbe091b2a19f0f1e514b5a727b85c269Test
https://pubmed.ncbi.nlm.nih.gov/32777442Test -
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المؤلفون: Marleen Groenen, Simon J. Mountford, Mengjie Liu, Philip E. Thompson, Nicholas D. Holliday, Rachel R. Richardson, Stephen J. Briddon
المصدر: Journal of medicinal chemistry. 63(10)
مصطلحات موضوعية: Stereochemistry, Dimer, Peptide, CHO Cells, Peptides, Cyclic, chemistry.chemical_compound, Cricetulus, Cricetinae, Drug Discovery, Animals, Humans, Receptor, chemistry.chemical_classification, biology, Dose-Response Relationship, Drug, Chinese hamster ovary cell, Neuropeptides, Antagonist, biology.organism_classification, Receptors, Neuropeptide Y, Ring size, HEK293 Cells, chemistry, Molecular Medicine, Protein Multimerization, Selectivity
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16598329f448b7f619db754ca8ac4cd0Test
https://pubmed.ncbi.nlm.nih.gov/32364733Test -
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المؤلفون: Sylvia Els-Heindl, Annette G. Beck-Sickinger, M. Florencia Sánchez, Ralph Wieneke, Robert Tampé
المصدر: Science (New York, N.Y.). 371(6536)
مصطلحات موضوعية: Ligands, 01 natural sciences, Models, Biological, Cell Line, Diffusion, 03 medical and health sciences, Cytosol, Cell Movement, Heterotrimeric G protein, Humans, Neuropeptide Y, Calcium Signaling, Mechanotransduction, Receptor, 030304 developmental biology, Calcium signaling, G protein-coupled receptor, Receptor Aggregation, 0303 health sciences, Multidisciplinary, 010405 organic chemistry, Chemistry, Lasers, Cell Membrane, Lipids, 0104 chemical sciences, Cell biology, Receptors, Neuropeptide Y, Calcium, Receptor clustering, Signal transduction, Signal Transduction
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5186c9b0d478ed3075b9c367d869cc1dTest
https://pubmed.ncbi.nlm.nih.gov/33632896Test -
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المصدر: Cell Communication and Signaling : CCS
Cell Communication and Signaling, Vol 18, Iss 1, Pp 1-16 (2020)مصطلحات موضوعية: 0301 basic medicine, Cell signaling, G protein, media_common.quotation_subject, Allosteric regulation, lcsh:Medicine, Cellular homeostasis, Desensitization, Neuropeptide Y receptors, GTP-Binding Protein alpha Subunits, Gi-Go, Biochemistry, 03 medical and health sciences, 0302 clinical medicine, GPCR, Humans, Neuropeptide Y, lcsh:QH573-671, Receptor, Internalization, Molecular Biology, media_common, G protein-coupled receptor, lcsh:Cytology, Chemistry, Research, lcsh:R, Cell Biology, Cell biology, Receptors, Neuropeptide Y, 030104 developmental biology, HEK293 Cells, Signal transduction, 030217 neurology & neurosurgery, Protein Binding, Signal Transduction
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::334ec9473cb646c84fdbb3cf8c3ab048Test
http://europepmc.org/articles/PMC7104545Test -
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المؤلفون: Steven L. Shipp, Guoqing Wang, Elizabeth R. Gilbert, Mark A. Cline, Yang Xiao
المصدر: Comparative biochemistry and physiology. Part A, Molecularintegrative physiology. 244
مصطلحات موضوعية: 0301 basic medicine, Physiology, Lipolysis, Subcutaneous Fat, Adipose tissue, Biology, Fatty Acids, Nonesterified, Biochemistry, Quail, 03 medical and health sciences, NEFA, Japan, biology.animal, Enhancer binding, Animals, RNA, Messenger, Molecular Biology, chemistry.chemical_classification, 030109 nutrition & dietetics, Coturnix japonica, Fatty acid, Fasting, Feeding Behavior, Neuropeptide Y receptor, biology.organism_classification, Receptors, Neuropeptide Y, 030104 developmental biology, chemistry, Animals, Newborn, CCAAT-Enhancer-Binding Proteins
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26e0745de5194204b90aa5e45f06d2deTest
https://pubmed.ncbi.nlm.nih.gov/32171800Test -
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المؤلفون: Benjamin K. Tsang, Reza Salehi, Yutaka Osuga, Patricia D.A. Lima, Yoko Urata
المصدر: Journal of Ovarian Research, Vol 13, Iss 1, Pp 1-11 (2020)
Journal of Ovarian Researchمصطلحات موضوعية: 0301 basic medicine, endocrine system, medicine.medical_specialty, MAP Kinase Signaling System, Blotting, Western, Proliferation, Apoptosis, 030209 endocrinology & metabolism, lcsh:Gynecology and obstetrics, Rats, Sprague-Dawley, 03 medical and health sciences, 0302 clinical medicine, Ovarian Follicle, Internal medicine, mental disorders, Follicular phase, medicine, Animals, Neuropeptide Y, Receptor, Autocrine signalling, Granulosa cell proliferation, Cells, Cultured, lcsh:RG1-991, Cell Proliferation, Granulosa Cells, Reverse Transcriptase Polymerase Chain Reaction, urogenital system, Chemistry, Research, Ovary, Obstetrics and Gynecology, Neuropeptide Y receptor, humanities, Receptors, Neuropeptide Y, Folliculogenesis, Neuropeptide, 030104 developmental biology, Endocrinology, Gene Expression Regulation, Oncology, Theca, Female
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0600cc543c55a9de20a0d8530bdd9349Test
https://doi.org/10.1186/s13048-019-0608-zTest -
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المؤلفون: Annette G. Beck-Sickinger, Peter Schmidt, Sarah Wistuba, Mathias Bosse, Alexander Vogel, Peter W. Hildebrand, Marcel Gauglitz, Daniel Huster, Vsevolod V. Gurevich, Anette Kaiser
المصدر: Molecules
Molecules, Vol 25, Iss 5489, p 5489 (2020)
Volume 25
Issue 23مصطلحات موضوعية: Magnetic Resonance Spectroscopy, Protein Conformation, Pharmaceutical Science, Molecular Dynamics Simulation, 010402 general chemistry, Neuropeptide Y Receptor Type 1, 01 natural sciences, Article, Analytical Chemistry, lcsh:QD241-441, 03 medical and health sciences, Molecular dynamics, Structure-Activity Relationship, GPCR, NMR spectroscopy, lcsh:Organic chemistry, Drug Discovery, Physical and Theoretical Chemistry, Lipid bilayer, Nuclear Magnetic Resonance, Biomolecular, 030304 developmental biology, Molecular switch, 0303 health sciences, Chemistry, arrestin, Organic Chemistry, MD simulation, Nuclear magnetic resonance spectroscopy, 500 Naturwissenschaften und Mathematik::570 Biowissenschaften, Biologie::570 Biowissenschaften, Biologie, structural dynamics, Recombinant Proteins, 0104 chemical sciences, Receptors, Neuropeptide Y, molecular switch, Transmembrane domain, Solid-state nuclear magnetic resonance, Chemistry (miscellaneous), Helix, Biophysics, Molecular Medicine
وصف الملف: application/pdf
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e4779e26d0088fb0f381f41cefdaab60Test