المؤلفون: Homer, Joshua A, Koelln, Rebecca A, Barrow, Andrew S, Gialelis, Timothy L, Boiarska, Zlata, Steinohrt, Nikita S, Lee, Erinna F, Yang, Wen-Hsuan, Johnson, Robert M, Chung, Taemoon, Habowski, Amber N, Vishwakarma, Dharmendra S, Bhunia, Debmalya, Avanzi, Charlotte, Moorhouse, Adam D, Jackson, Mary, Tuveson, David A, Lyons, Scott K, Lukey, Michael J, Fairlie, W Douglas, Haider, Shozeb M, Steinmetz, Michel O, Prota, Andrea E, Moses, John E

مصطلحات موضوعية: Accelerated SuFEx Click Chemistry, chemistry, click chemistry, techniques

وصف الملف: application/pdf

العلاقة: https://repository.cshl.edu/id/eprint/41466/1/Homer_2024_Modular_synthesis.pdfTest; Homer, Joshua A, Koelln, Rebecca A, Barrow, Andrew S, Gialelis, Timothy L, Boiarska, Zlata, Steinohrt, Nikita S, Lee, Erinna F, Yang, Wen-Hsuan, Johnson, Robert M, Chung, Taemoon, Habowski, Amber N, Vishwakarma, Dharmendra S, Bhunia, Debmalya, Avanzi, Charlotte, Moorhouse, Adam D, Jackson, Mary, Tuveson, David A, Lyons, Scott K, Lukey, Michael J, Fairlie, W Douglas, Haider, Shozeb M, Steinmetz, Michel O, Prota, Andrea E, Moses, John E (March 2024) Modular synthesis of functional libraries by accelerated SuFEx click chemistry. Chemical Science, 15 (11). pp. 3879-3892. ISSN 2041-6520 (Public Dataset)

الإتاحة: https://doi.org/10.1039/d3sc05729aTest
https://repository.cshl.edu/id/eprint/41466Test/
https://repository.cshl.edu/id/eprint/41466/1/Homer_2024_Modular_synthesis.pdfTest
https://www.ncbi.nlm.nih.gov/pubmed/38487227Test

المؤلفون: Jost, Marco, Chen, Yuwen, Gilbert, Luke A, Horlbeck, Max A, Krenning, Lenno, Menchon, Grégory, Rai, Ankit, Cho, Min Y, Stern, Jacob J, Prota, Andrea E, Kampmann, Martin, Akhmanova, Anna, Steinmetz, Michel O, Tanenbaum, Marvin E, Weissman, Jonathan S, Sub Cell Biology, Celbiologie

المساهمون: Hubrecht Institute for Developmental Biology and Stem Cell Research, Sub Cell Biology, Celbiologie

المصدر: Molecular Cell
Molecular Cell, 79(1), 191. Cell Press
Molecular Cell, 79(1), 191-198.e3. Cell Press

مصطلحات موضوعية: Protein Conformation, Mutant, Cell, medicine.disease_cause, Crystallography, X-Ray, Microtubules, 0302 clinical medicine, Tubulin, Neoplasms, Sulfones, Cells, Cultured, Glycine/analogs & derivatives, Mutation, 0303 health sciences, Cultured, Crystallography, biology, Chemistry, rigosertib, Rigosertib, drug mechanism of action, 3. Good health, Cell biology, medicine.anatomical_structure, chemical genetics, Pharmaceutical Preparations, 030220 oncology & carcinogenesis, Pharmaceutical Preparations/chemistry, Drug Contamination, Antineoplastic Agents/pharmacology, Cells, Glycine, Antineoplastic Agents, Article, 03 medical and health sciences, CRISPRa, Tubulin/chemistry, Microtubule, medicine, Humans, Binding site, Molecular Biology, 030304 developmental biology, Cell Proliferation, drug target identification, CRISPRi, Cell Biology, In vitro, Neoplasms/drug therapy, Sulfones/pharmacology, Cancer cell, X-Ray, biology.protein, Microtubules/drug effects, 030217 neurology & neurosurgery

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78e69dbc0caaaee2c44b7494dfd72fa4Test
https://pubmed.ncbi.nlm.nih.gov/32619469Test

المؤلفون: Rezabkova, Lenka, Jiang, Kai, Capitani, Guido, Prota, Andrea E, Akhmanova, Anna, Steinmetz, Michel O., Kammerer, Richard A., Sub Cell Biology, Celbiologie

المساهمون: Sub Cell Biology, Celbiologie

المصدر: Scientific Reports, 7(1). NLM (Medline)
Scientific Reports, Vol 7, Iss 1, Pp 1-8 (2017)
Scientific Reports

مصطلحات موضوعية: Models, Molecular, 0301 basic medicine, Protein Conformation, Protein subunit, ATPase, Biophysics, lcsh:Medicine, Katanin, Plasma protein binding, Crystallography, X-Ray, DNA-binding protein, Biochemistry, Article, Mice, 03 medical and health sciences, 0302 clinical medicine, Protein structure, Microtubule, Animals, Protein Interaction Domains and Motifs, Protein Interaction Maps, lcsh:Science, X-ray crystallography, Multidisciplinary, biology, Chemistry, lcsh:R, Cell biology, 030104 developmental biology, biology.protein, lcsh:Q, Protein Multimerization, 030217 neurology & neurosurgery, Function (biology), Protein Binding

وصف الملف: image/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::307678e69e4cc7b883f3a3fc8cc5fb01Test
https://dspace.library.uu.nl/handle/1874/359423Test

المؤلفون: Jiang, Kai, Faltova, Lenka, Hua, Shasha, Capitani, Guido, Prota, Andrea E, Landgraf, Christiane, Volkmer, Rudolf, Kammerer, Richard A, Steinmetz, Michel O, Akhmanova, Anna, Sub Cell Biology, Celbiologie

المصدر: Structure with Folding & design, 26(3), 375. Cell Press

مصطلحات موضوعية: 0301 basic medicine, Models, Molecular, Katanin complex, Protein Conformation, ATPase, ASPM, Katanin, Microtubules, 03 medical and health sciences, Mice, 0302 clinical medicine, Protein Domains, Structural Biology, Microtubule, Hydrolase, microtubule minus end, CAMSAP, Animals, Humans, microcephaly, Molecular Biology, Mitosis, X-ray crystallography, Gene Editing, patronin, Binding Sites, biology, Chemistry, microtubule dynamics, Cell biology, Microtubule minus-end, Cytoskeletal Proteins, 030104 developmental biology, biology.protein, Mutagenesis, Site-Directed, Microtubule-Associated Proteins, 030217 neurology & neurosurgery, Protein Binding

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36dff6e37bbd4bd11321651f23e35de6Test
https://pubmed.ncbi.nlm.nih.gov/29395789Test

المؤلفون: Boiarska, Zlata, Pérez‐Peña, Helena, Abel, Anne‐Catherine, Marzullo, Paola, Álvarez‐Bernad, Beatriz, Bonato, Francesca, Santini, Benedetta, Horvath, Dragos, Lucena‐Agell, Daniel, Vasile, Francesca, Sironi, Maurizio, Díaz, J. Fernando, Prota, Andrea E., Pieraccini, Stefano, Passarella, Daniele

المصدر: Chemistry - A European Journal; 1/24/2023, Vol. 29 Issue 5, p1-2, 2p

مصطلحات موضوعية: MICROTUBULES, CHEMISTRY

المؤلفون: Doodhi, Harinath, Prota, Andrea E, Rodríguez-García, Ruddi, Xiao, Hui, Custar, Daniel W, Bargsten, Katja, Katrukha, Eugene A, Hilbert, Manuel, Hua, Shasha, Jiang, Kai, Grigoriev, Ilya, Yang, Chia-Ping H, Cox, David, Horwitz, Susan Band, Kapitein, Lukas C, Akhmanova, Anna, Steinmetz, Michel O, Celbiologie, Sub Cell Biology

المساهمون: Celbiologie, Sub Cell Biology

المصدر: Current Biology, 26(13), 1713. Cell Press
Current Biology

مصطلحات موضوعية: 0301 basic medicine, Antimitotic Agents, Crystallography, X-Ray, Microtubules, General Biochemistry, Genetics and Molecular Biology, 03 medical and health sciences, chemistry.chemical_compound, Tubulin, Microtubule, Taverne, Animals, Furans, 030102 biochemistry & molecular biology, biology, Ketones, A-site, 030104 developmental biology, chemistry, Lattice defects, biology.protein, Biophysics, Cattle, Elongation, General Agricultural and Biological Sciences, Eribulin

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e1b754efee266a785fdbe3a4eba9cb6Test
https://doi.org/10.1016/j.cub.2016.04.053Test

المؤلفون: Waight, Andrew B., Bargsten, Katja, Doronina, Svetlana, Steinmetz, Michel O., Sussman, Django, Prota, Andrea E.

المصدر: PLoS ONE; 8/12/2016, Vol. 11 Issue 8, p1-14, 14p

مصطلحات موضوعية: CANCER cells, ANTINEOPLASTIC agents, TUBULINS, MICROTUBULES, DRUG synergism

المؤلفون: Paola Marzullo, Maurizio Sironi, Daniel Lucena-Agell, J. Fernando Díaz, Daniele Passarella, Helena Pérez-Peña, Zlata Boiarska, Stefano Pieraccini, Beatriz Álvarez-Bernad, Anne-Catherine Abel, Karl-Heinz Altmann, Andrea E. Prota, Francesca Vasile

المساهمون: European Commission, Ministerio de Ciencia e Innovación (España), Consejo Superior de Investigaciones Científicas (España), Fundación Tatiana Pérez de Guzmán el Bueno, Università degli Studi di Milano, Marzullo, Paola, Boiarska, Zlata, Abel, Anne-Catherine, Álvarez-Bernad, Beatriz, Lucena-Agell, Daniel, Vasile, Francesca, Sironi, Maurizio, Altmann, Karl-Heinz, Prota, Andrea E., Díaz, José Fernando, Pieraccini, Stefano, Passarella, D., Marzullo, Paola [0000-0003-4249-8794], Boiarska, Zlata [0000-0003-1235-5717], Abel, Anne-Catherine [0000-0002-2392-9029], Álvarez-Bernad, Beatriz [0000-0002-2492-9215], Lucena-Agell, Daniel [0000-0001-7198-2900], Vasile, Francesca [0000-0002-3926-8261], Sironi, Maurizio [0000-0001-5822-4849], Altmann, Karl-Heinz [0000-0002-0747-9734], Prota, Andrea E. [0000-0003-0875-5339], Díaz, José Fernando [0000-0003-2743-3319], Pieraccini, Stefano [0000-0002-7672-0720], Passarella, D. [0000-0001-6180-9581]

المصدر: Chemistry – A European Journal
Digital.CSIC. Repositorio Institucional del CSIC
instname
Chemistry-A European Journal, 28 (2)

مصطلحات موضوعية: maytansine binding site, Cancer therapy, 01 natural sciences, Catalysis, microtubules, Acylation, 03 medical and health sciences, Maytansinol, Microtubule, Neoplasms, Humans, Molecule, Maytansine, 030304 developmental biology, 0303 health sciences, biology, 010405 organic chemistry, Chemistry, Organic Chemistry, General Chemistry, maytansinol, tubulin, tubulin binders, Combinatorial chemistry, Tubulin Modulators, 0104 chemical sciences, 3. Good health, Tubulin, Docking (molecular), biology.protein

وصف الملف: application/application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3462138c4725ef6c10a3c34703000338Test
http://hdl.handle.net/10261/257058Test

المؤلفون: María A. Oliva, Susan Matthew, Ranjala Ratnayake, Hendrik Luesch, Francesca Bonato, April L. Risinger, Andrea E. Prota, Daniel Lucena-Agell, Seok Ting Lim, Qi-Yin Chen, J. Fernando Díaz, Charles S. Fermaintt, Xiaomeng Wang, Valerie J. Paul

المساهمون: National Cancer Institute (US), National Institute of General Medical Sciences (US), University of Florida, Ministerio de Ciencia e Innovación (España), Consejo Superior de Investigaciones Científicas (España), European Commission, Matthew, S. [0000-0003-4943-4777], Chen, Qi-Yin [0000-0002-4364-1057], Ratnayake, R. [0000-0002-5980-2070], Fermaintt, Charles S. [0000-0001-8140-5461], Lucena-Agell, Daniel [0000-0001-7198-2900], Bonato, Francesca [0000-0002-0579-2874], Prota, Andrea E. [0000-0003-0875-5339], Lim, Seok Ting [0000-0002-5173-5715], Wang, Xiaomeng [0000-0002-1036-2764], Díaz, José Fernando [0000-0003-2743-3319], Risinger, April L. [0000-0002-4363-3268], Paul, Valerie J. [0000-0002-4691-1569], Oliva, María A. [0000-0002-2215-4639], Luesch, H. [0000-0002-4091-7492], Matthew, S., Chen, Qi-Yin, Ratnayake, R., Fermaintt, Charles S., Lucena-Agell, Daniel, Bonato, Francesca, Prota, Andrea E., Lim, Seok Ting, Wang, Xiaomeng, Díaz, José Fernando, Risinger, April L., Paul, Valerie J., Oliva, María A., Luesch, H.

المصدر: Digital.CSIC. Repositorio Institucional del CSIC
instname
Proc Natl Acad Sci U S A

مصطلحات موضوعية: Models, Molecular, Protein Conformation, alpha-Helical, Marine natural product, Antineoplastic Agents, Apoptosis, Total synthesis, Crystallography, X-Ray, Cyanobacteria, 01 natural sciences, Pentapeptide repeat, Microtubules, 03 medical and health sciences, chemistry.chemical_compound, Bacterial Proteins, Microtubule, Tubulin, Cell Line, Tumor, Depsipeptides, Drug Discovery, Humans, Maytansine, Protein Interaction Domains and Motifs, Binding site, Vinca Alkaloids, 030304 developmental biology, 0303 health sciences, Biological Products, Multidisciplinary, Natural product, Binding Sites, biology, Chemotype, 010405 organic chemistry, Biological Sciences, HCT116 Cells, In vitro, Tubulin Modulators, 3. Good health, 0104 chemical sciences, chemistry, Biochemistry, Pyrones, biology.protein, Protein Conformation, beta-Strand, Taxoids, Colchicine, Protein Binding

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11c3e59a13700d6bc432e5889d60967dTest
http://hdl.handle.net/10261/235164Test

المؤلفون: Isabel Barasoain, Andrea E. Prota, J. Fernando Díaz, Francisco de Asís Balaguer, Christina Kamma-Lorger, Siou Ku, María A. Oliva, Rubén M. Buey, Toshiki Yagi, Laurence Duchesne, Denis Chrétien, Daniel Lucena-Agell, Shinji Kamimura, Juan Estévez-Gallego, Michel O. Steinmetz, Hiroyuki Iwamoto, Fernando Josa-Prado

المساهمون: Consejo Superior de Investigaciones Científicas [Madrid] (CSIC), Institut de Génétique et Développement de Rennes (IGDR), Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )-Centre National de la Recherche Scientifique (CNRS)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES), Department of Structural Engineering - University of Naples 'Federico II', Microbiologia Molecular, Centro Investigaciones Biologicas. CSIC, Institut Jacques Monod (IJM (UMR_7592)), Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), Biomolecular Research, Structural Biology, Paul Scherrer Institute (PSI), Interactions cellulaires et moléculaires (ICM), Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Centre National de la Recherche Scientifique (CNRS), BFU2013-47014P, Ministerio de Economía y Competitividad, H2020-MSCA-ITN-EJD-860070, H2020 European Research Council, 31003A_166608, Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung, KAKENHI 16K07328/17H03668, Japan Society for the Promotion of Science, ANR-16-C11-0017-01, Agence Nationale de la Recherche, 2019B1365, SPring-8 Proposal, Ministerio de Economía y Competitividad (España), Ministerio de Ciencia e Innovación (España), European Commission, Swiss National Science Foundation, Ministerio de Educación, Cultura y Deporte (España), Estévez-Gallego, Juan, Josa-Prado, Fernando, Martínez Buey, Rubén, Prota, Andrea E., Lucena-Agell, Daniel, Kamma-Lorger, C.S., Yagi, Toshiki, Barasoain, Isabel, Steinmetz, Michel O., Kamimura, Shinji, Díaz, José Fernando, Oliva, María A., Estévez-Gallego, Juan [0000-0003-3889-8488 ], Josa-Prado, Fernando [0000-0002-6162-3231], Martínez Buey, Rubén [0000-0003-1263-0221], Prota, Andrea E. [0000-0003-0875-5339], Lucena-Agell, Daniel [0000-0001-7314-8696], Kamma-Lorger, C.S. [0000-0001-6686-9161], Yagi, Toshiki[0000-0002-1379-460X], Barasoain, Isabel [0000-0003-2013-085X], Steinmetz, Michel O. [0000-0001-6157-3687], Kamimura, Shinji [0000-0003-4359-0859], Díaz, José Fernando [0000-0003-2743-3319], Oliva, María A. [0000-0002-2215-4639], Université de Rennes (UR)-Centre National de la Recherche Scientifique (CNRS)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), University of Naples Federico II = Università degli studi di Napoli Federico II, Université de Rennes (UR)-Centre National de la Recherche Scientifique (CNRS), ANR-16-CE11-0017,Tubulin_GTP,Mécanisme d'hydrolyse du GTP lors de l'assemblage des microtubules(2016)

المصدر: eLife
eLife, eLife Sciences Publication, 2020, 9, pp.e50155. ⟨10.7554/eLife.50155⟩
Digital.CSIC. Repositorio Institucional del CSIC
instname
'eLife ', vol: 9, pages: e50155-1-e50155-26 (2020)
eLife, Vol 9 (2020)
eLife, 2020, 9, pp.e50155. ⟨10.7554/eLife.50155⟩

مصطلحات موضوعية: Models, Molecular, none, Structural Biology and Molecular Biophysics, [SDV]Life Sciences [q-bio], Molecular Conformation, GTPase, Microtubules, 0302 clinical medicine, Tubulin, structural biology, Nucleotide, Biology (General), ComputingMilieux_MISCELLANEOUS, chemistry.chemical_classification, 0303 health sciences, taxol, biology, Chemistry, General Neuroscience, dynamic instability, General Medicine, Molecular biophysics, Medicine, Guanosine Triphosphate, Structural biology, Research Article, microtubule, QH301-705.5, Taxol, Science, Microtubule, Dynamic instability, macromolecular substances, Guanosine Diphosphate, General Biochemistry, Genetics and Molecular Biology, Structure-Activity Relationship, 03 medical and health sciences, None, Pi, molecular biophysics, 030304 developmental biology, GTP-cap, General Immunology and Microbiology, Cell growth, Cryoelectron Microscopy, Hydrogen Bonding, biology.protein, Biophysics, 030217 neurology & neurosurgery

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77f00c01fd31baf004ef430cbc4a55d6Test
https://hal.archives-ouvertes.fr/hal-02552246/file/hal-02552246.pdfTest