Role of Lactobacillus plantarum MTCC1325 in membrane-bound transport ATPases system in Alzheimer’s disease-induced rat brain
| العنوان: | Role of Lactobacillus plantarum MTCC1325 in membrane-bound transport ATPases system in Alzheimer’s disease-induced rat brain |
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| المؤلفون: | Kuna Yellamma, Nimgampalle Mallikarjuna, Kukkarasapalli Praveen |
| المصدر: | BioImpacts, Vol 6, Iss 4, Pp 203-209 (2016) |
| بيانات النشر: | Maad Rayan Publishing Company, 2016. |
| سنة النشر: | 2016 |
| مصطلحات موضوعية: | 0301 basic medicine, ATPase, medicine.medical_treatment, Intraperitoneal injection, ATPases, Pharmaceutical Science, Hippocampus, Pharmacology, medicine.disease_cause, General Biochemistry, Genetics and Molecular Biology, Lipid peroxidation, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, D-Galactose, medicine, lcsh:QH301-705.5, lcsh:R5-920, biology, Neurodegeneration, General Medicine, biology.organism_classification, medicine.disease, 030104 developmental biology, medicine.anatomical_structure, lcsh:Biology (General), chemistry, Cerebral cortex, Immunology, biology.protein, 030211 gastroenterology & hepatology, lcsh:Medicine (General), Alzheimer’s disease, Lactobacillus plantarum, Oxidative stress |
| الوصف: | Introduction: Alzheimer’s disease (AD) is a neurodegenerative disorder, clinically characterized by memory dysfunction and progressive loss of cognition. No curative therapeutic or drug is available for the complete cure of this disease. The present study was aimed to evaluate the efficacy of Lactobacillus plantarum MTCC1325 in ATPases activity in the selected brain regions of rats induced with Alzheimer’s. Methods: For the study, 48 healthy Wistar rats were divided into four groups: group I as control group, group II as AD model (AD induced by intraperitoneal injection of D-Galactose, 120 mg/kg body weight for 6 weeks), group III as normal control rats which were orally administered only with L. plantarum MTCC1325 for 60 days, and group IV where the AD-induced rats simultaneously received oral treatment of L. plantarum MTCC1325 (10ml/kg body weight, 12×108 CFU/mL) for 60 days. The well known membrane bound transport enzymes including Na+, K+-ATPases, Ca2+-ATPases, and Mg2+-ATPases were assayed in the selected brain regions of hippocampus and cerebral cortex in all four groups of rats at selected time intervals. Results: Chronic injection of D-Galactose caused lipid peroxidation, oxidative stress, and mitochondrial dysfunction leading to the damage of neurons in the brain, finally bringing a significant decrease (-20%) in the brain total membrane bound ATPases over the controls. Contrary to this, treatment of AD-induced rats with L. plantarum MTCC1325 reverted all the constituents of ATPase enzymes to near normal levels within 30 days. Conclusion: Lactobacillus plantarum MTCC1325 exerted a beneficial action on the entire ATPases system in AD-induced rat brain by delaying neurodegeneration. |
| تدمد: | 2228-5652 2228-5660 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e385d8a0f4c1b683d11c039e24072ab2Test https://doi.org/10.15171/bi.2016.27Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....e385d8a0f4c1b683d11c039e24072ab2 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 22285652 22285660 |
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