المؤلفون: Simona Saponara, Massimo Baroni, Domenico Spinelli, Barbara Cosimelli, Elda Severi, Pierfranco Ioan, Camillo Rosano, Roberta Budriesi, Fabio Fusi, Rosanna Matucci, Emanuele Carosati, Simon Cross, Maria Frosini, Maurizio Viale, Alberto Chiarini, Matteo Micucci

المساهمون: Spinelli, D., Budriesi, R., Cosimelli, B., Severi, E., Micucci, M., Baroni, M., Fusi, F., Ioan, P., Cross, S., Frosini, M., Saponara, S., Matucci, R., Rosano, C., Viale, M., Chiarini, A., Carosati, E., Domenico, Spinelli, Roberta, Budriesi, Cosimelli, Barbara, Elda, Severi, Matteo, Micucci, Massimo, Baroni, Fabio, Fusi, Pierfranco, Ioan, Simon, Cro, Maria, Frosini, Simona, Saponara, Rosanna, Matucci, Camillo, Rosano, Maurizio, Viale, Alberto, Chiarini, Emanuele, Carosati

المصدر: Molecules, Vol 19, Iss 10, Pp 16543-16572 (2014)
Molecules
Volume 19
Issue 10
Pages 16543-16572

مصطلحات موضوعية: oxadiazolothiazinones, Pharmaceutical Science, Quantitative Structure-Activity Relationship, Multidrug resistance, ternary complex, Analytical Chemistry, Heterocyclic Compounds, Drug Discovery, Ternary complex, L-type calcium channel, Oxadiazoles, Chemistry, Calcium Channel Blockers, Molecular Docking Simulation, Subfamily B, Chemistry (miscellaneous), docking, Molecular Medicine, ATP Binding Cassette Transporter, Subfamily B, Animals, Guinea Pigs, Heart Atria, Muscle, Smooth, Structural Homology, Protein, Muscle, Smooth, Pharmacophore, structure-activity relationship, L-type calcium channels, oxadiazolothiazinone, P-glycoprotein, Quantitative structure–activity relationship, Stereochemistry, In silico, negative inotropic activity, ATP Binding Cassette Transporter, Fingerprints for Ligands and Proteins (FLAP), L-Type Calcium Channels (LTCC), Article, lcsh:QD241-441, lcsh:Organic chemistry, Homology modeling, Physical and Theoretical Chemistry, multidrug resistance (MDR1), 3D-QSAR, Structural Homology, Virtual screening, Calcium channel, Protein, Organic Chemistry, Combinatorial chemistry, Docking (molecular), pharmacophore modeling

وصف الملف: application/pdf; STAMPA

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61554762b7203fa9fbc751ecaa3e5b93Test
https://hdl.handle.net/11576/2696050Test

المؤلفون: Carlo Franchini, Jean-François Desaphy, Marilena Muraglia, Carla Ghelardini, M. Norcini, Antonella Dipalma, Filomena Corbo, D. Conte Camerino, Marta Nesi, Marco Pistolozzi, Rosanna Matucci, Carlo Bertucci

المساهمون: Ghelardini C, Desaphy JF, Muraglia M, Corbo F, Matucci R, Dipalma A, Bertucci C, Pistolozzi M, Nesi M, Norcini M, Franchini C, Camerino DC.

المصدر: Neuroscience. 169(2)

مصطلحات موضوعية: Male, PHARMACOKINETICS, Patch-Clamp Techniques, ALBUMIN BINDING, Cell Survival, Tocainide, Analgesic, Muscle Proteins, Pain, Pharmacology, Sodium Channels, Cell Line, Rats, Sprague-Dawley, Sodium channel blocker, In vivo, Threshold of pain, medicine, Animals, Humans, NAV1.4 Voltage-Gated Sodium Channel, Serum Albumin, Analgesics, Chemistry, General Neuroscience, Sodium channel, NAV1.7 Voltage-Gated Sodium Channel, Chronic pain, Peripheral Nervous System Diseases, medicine.disease, Rats, Hyperalgesia, Neuropathic pain, VOLTAGE-GATED SODIUM CHANNELS, medicine.drug, Protein Binding, Sodium Channel Blockers

وصف الملف: STAMPA

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea47cba085564d6b9c8cda0d662872d1Test
https://pubmed.ncbi.nlm.nih.gov/20580661Test

المؤلفون: Fabio Fusi, Domenico Spinelli, Alberto Chiarini, Raffaella Spisani, Emanuele Carosati, Philip J. Stephens, Maria Frosini, Roberta Budriesi, Gabriele Cruciani, Francesco Gasparrini, Barbara Cosimelli, Frank J. Devlin, Alessia Ciogli, Pierfranco Ioan, Rosanna Matucci

المساهمون: Carosati, E, Cruciani, G, Chiarini, A, Budriesi, R, Ioan, P, Spisani, R, Spinelli, D, Cosimelli, Barbara, Fusi, F, Frosini, M, Matucci, R, Gasparrini, F, Ciogli, A, STEPHENS P., J, Devlin, F. J.

مصطلحات موضوعية: binding, Calcium Channels, L-Type, calcium channel antagonist, Stereochemistry, drug design, In silico, Guinea Pigs, Drug Evaluation, Preclinical, Ligands, Structure-Activity Relationship, chemotypes, ligand channel interaction, medicinal chemistry, Drug Discovery, Animals, Myocytes, Cardiac, Heart Atria, Calcium entry, Virtual screening, Oxadiazoles, Binding Sites, Molecular Structure, Chemistry, Calcium channel, diltiazem, Absolute configuration, Muscle, Smooth, Stereoisomerism, Papillary Muscles, Calcium Channel Blockers, virtual screening, circular dichroism, Databases as Topic, Vibrational circular dichroism, calcium entry blocker, Molecular Medicine, Female, synthesi

وصف الملف: STAMPA

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::766918fe8cc1cd3e9d24046cf16cf76aTest
http://hdl.handle.net/11588/102166Test