يعرض 1 - 10 نتائج من 23 نتيجة بحث عن '"Matthias John"', وقت الاستعلام: 1.16s تنقيح النتائج
  1. 1
    Conformational rearrangements of RIG-I receptor on formation of a multiprotein:dsRNA assembly

    المؤلفون: Anna Roth, Anthony J. Sadler, Kerstin Jahn-Hofmann, Matthew C.J. Wilce, Die Wang, Jason M. Brouwer, Matthias John, Simone A. Beckham, Jacqueline A. Wilce, Bryan R.G. Williams

    المصدر: Nucleic Acids Research

    مصطلحات موضوعية: Models, Molecular, viruses, Retinoic acid, chemical and pharmacologic phenomena, Plasma protein binding, Biology, Protein Structure, Secondary, DEAD-box RNA Helicases, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, X-Ray Diffraction, Structural Biology, Scattering, Small Angle, Genetics, Humans, Trypsin, Receptors, Immunologic, DEAD Box Protein 58, Protein Structure, Quaternary, 030304 developmental biology, RNA, Double-Stranded, 0303 health sciences, RIG-I, RNA, virus diseases, MDA5, biochemical phenomena, metabolism, and nutrition, Peptide Fragments, Cell biology, Protein Structure, Tertiary, RNA silencing, chemistry, Biochemistry, Cytoplasm, Proteolysis, Chromatography, Gel, biological phenomena, cell phenomena, and immunity, Apoproteins, 030217 neurology & neurosurgery, Protein Binding

    الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82a0cdee54b0c228a51711465017a317Test
    http://europepmc.org/articles/PMC3597671Test


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  2. 2
    Therapeutic RNAi targeting PCSK9 acutely lowers plasma cholesterol in rodents and LDL cholesterol in nonhuman primates

    المؤلفون: K. Narayanannair Jayaprakash, Maria Frank-Kamenetsky, Daniel G. Anderson, Robert Langer, Yupeng Fan, Tracy Zimmermann, Muthiah Manoharan, Ingo Röhl, Kevin Fitzgerald, Timothy Racie, Martin Maier, Christina Gamba-Vitalo, Jürgen Soutschek, Akin Akinc, Norma N. Anderson, Lubomir Nechev, Pamela Tan, Muthusamy Jayaraman, Gang Wang, Philipp Hadwiger, Jay D. Horton, Klaus Charisse, Victor Koteliansky, Aldo Grefhorst, David Butler, Matthias John, Antonin de Fougerolles, Robert Dorkin, Timothy Read, Birgit Bramlage, Hans-Peter Vornlocher, Jamie Wong, Kallanthottathil G. Rajeev

    المساهمون: Experimental Vascular Medicine, Vascular Medicine, AGEM - Amsterdam Gastroenterology Endocrinology Metabolism

    المصدر: Proceedings of the National Academy of Sciences of the United States of America, 105(33), 11915-11920. National Academy of Sciences

    مصطلحات موضوعية: Primates, Small interfering RNA, Time Factors, Apolipoprotein B, Pharmacology, RNAi Therapeutics, Mice, chemistry.chemical_compound, RNA interference, Animals, Humans, Gene silencing, RNA, Messenger, RNA, Small Interfering, Mice, Knockout, Multidisciplinary, Molecular Structure, biology, Cholesterol, PCSK9, Serine Endopeptidases, Cholesterol, LDL, Biological Sciences, Molecular biology, Tissue LDLR levels, Rats, Liver, chemistry, LDL receptor, biology.protein, lipids (amino acids, peptides, and proteins), Plasma PCSK9

    الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88c0eef01dd5bd57cc9c0e254fce8aa5Test
    https://doi.org/10.1073/pnas.0805434105Test


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  3. 3
    Influence of substitutions on asymmetric dihydroxychlorins with regard to intracellular uptake, subcellular localization and photosensitization of Jurkat cells

    المؤلفون: Mathias O. Senge, Beate Röder, Saleh Al Omari, Arno Wiehe, Matthias John, Maria Nöbel, Fritz Böhm, Fiorenza Rancan

    المصدر: Journal of Photochemistry and Photobiology B: Biology. 78:17-28

    مصطلحات موضوعية: Programmed cell death, Porphyrins, medicine.medical_treatment, Biophysics, Apoptosis, Photodynamic therapy, Biology, Jurkat cells, Jurkat Cells, Necrosis, symbols.namesake, chemistry.chemical_compound, Hydroxides, medicine, Humans, Radiology, Nuclear Medicine and imaging, Phospholipids, Liposome, Photosensitizing Agents, Radiation, Molecular Structure, Radiological and Ultrasound Technology, Biological Transport, Stereoisomerism, Golgi apparatus, Subcellular localization, Cell biology, chemistry, Chlorin, symbols, Institut für Chemie, Intracellular

    الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c74ac30995d4620d0b591a8865bc28a8Test
    https://doi.org/10.1016/j.jphotobiol.2004.08.010Test


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  4. 4
    Increased interleukin-10 and macrophage inflammatoryprotein-1α release from blood monocytesex vivoduringlate-phase response to allergen in asthma

    المؤلفون: PJ Barnes, Sam Lim, Joachim Seybold, Matthias John, D. Taylor, Kian Fan Chung, C. Witt

    المصدر: Allergy. 55:488-494

    مصطلحات موضوعية: Lipopolysaccharide, business.industry, medicine.medical_treatment, Monocyte, Immunology, Inflammation, medicine.disease_cause, Interleukin 10, chemistry.chemical_compound, Cytokine, Allergen, medicine.anatomical_structure, chemistry, medicine, Immunology and Allergy, Macrophage, medicine.symptom, business, Ex vivo

    الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::c47a4725ec943af3362f9cc8caf07f31Test
    https://doi.org/10.1034/j.1398-9995.2000.00483.xTest


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  5. 5
    Quantification of free RNA in serum and bronchial lavage: a new diagnostic tool in lung cancer detection?

    المؤلفون: Michael Fleischhacker, E. Engel, Matthias John, Sabine Weickmann, T. Carstensen, Christian Witt, Bernd Schmidt

    المصدر: Lung Cancer. 48:145-147

    مصطلحات موضوعية: Adult, Male, Pulmonary and Respiratory Medicine, Cancer Research, Pathology, medicine.medical_specialty, Lung Neoplasms, Sensitivity and Specificity, chemistry.chemical_compound, Carcinoma, Non-Small-Cell Lung, Biomarkers, Tumor, medicine, Humans, Carcinoma, Small Cell, Lung cancer, Aged, Aged, 80 and over, medicine.diagnostic_test, Reverse Transcriptase Polymerase Chain Reaction, business.industry, Cancer, RNA, DNA, Neoplasm, Middle Aged, medicine.disease, Molecular biology, Cell-Free Nucleic Acids, Bronchoalveolar lavage, Oncology, chemistry, Nucleic acid, Female, RNA extraction, business, Bronchoalveolar Lavage Fluid, DNA

    الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca11bdf76458158f75a88959f0540a1eTest
    https://doi.org/10.1016/j.lungcan.2004.09.013Test


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  6. 6
    Interleukin 13 inhibits macrophage inflammatory protein-1 alpha production from human alveolar macrophages and monocytes

    المؤلفون: G. Roesems, P. J. Barnes, Kian Fan Chung, Peter J. Jose, Matthias John, N. Berkman

    المصدر: American Journal of Respiratory Cell and Molecular Biology. 15:382-389

    مصطلحات موضوعية: Lipopolysaccharides, Pulmonary and Respiratory Medicine, Time Factors, Lipopolysaccharide, Clinical Biochemistry, Monocytes, chemistry.chemical_compound, Macrophages, Alveolar, medicine, Protein biosynthesis, Humans, RNA, Messenger, Cycloheximide, Chemokine CCL4, Molecular Biology, Macrophage inflammatory protein, Chemokine CCL3, Protein Synthesis Inhibitors, Messenger RNA, Interleukin-13, Dose-Response Relationship, Drug, Activator (genetics), Monocyte, Proteins, Cell Biology, Macrophage Inflammatory Proteins, Blotting, Northern, Molecular biology, Growth Inhibitors, In vitro, Interleukin-10, medicine.anatomical_structure, chemistry, Immunology, Interleukin 13, Interleukin-4

    الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c98b6810bd880974e9e54f08c668ac1aTest
    https://doi.org/10.1165/ajrcmb.15.3.8810643Test


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  7. 7
    Hepatic, MyD88-dependent toll-like receptors are activated by in vivo application of LNP01-formulated siRNAs

    المؤلفون: Kerstin Jahn-Hofmann, Ruth Broering, Matthias John, K Kleinehr, Joerg F. Schlaak, L Ickenstein, G. Gerken, CI Real

    المصدر: Zeitschrift für Gastroenterologie. 50

    مصطلحات موضوعية: Small interfering RNA, biology, In vivo, Chemistry, Toll, Gastroenterology, biology.protein, Receptor, Cell biology

    الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::6ae5382fa9c8b26edcbdbb9924c91a05Test
    https://doi.org/10.1055/s-0032-1323937Test


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  8. 8
    Targeted siRNA Delivery and mRNA Knockdown Mediated by Bispecific Digoxigenin-binding Antibodies

    المؤلفون: Silke Metz, Eike Hoffmann, Weijun Cheng, Kerstin Jahn-Hofmann, Jan Olaf Stracke, Werner Scheuer, Britta Schneider, Olaf Mundigl, Hans Herweijer, Wilma Lau, Simone Dill, Matthias John, Ludger M lckenstein, Karin Daub, Zane C. Neal, Michael Grote, James Ludtke, Rebecca Croasdale, Frieder Bauss, Alexander Haas, Helmut Burtscher, Birgit Bramlage, Ulrjch Brinkmann

    المصدر: Molecular Therapy: Nucleic Acids, Vol 1, Iss C (2012)
    Molecular Therapy. Nucleic Acids

    مصطلحات موضوعية: siRNA delivery, Small interfering RNA, Gene knockdown, Messenger RNA, medicine.diagnostic_test, lcsh:RM1-950, CD22, Biology, lipid nanoparticle, Molecular biology, Flow cytometry, bispecific antibody, chemistry.chemical_compound, dynamic polyconjugate, RNA interference, lcsh:Therapeutics. Pharmacology, chemistry, Antigen, hapten, Drug Discovery, medicine, Molecular Medicine, Digoxigenin, Original Article

    الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4cb0d21ca8c5f857cf9217edf1aa26a8Test


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  9. 9
    Hepatic toll-like receptors can be activated by application of siRNAs in vivo via MyD88-dependent pathways which can be controlled by chemical ribose modifications of the siRNA backbone

    المؤلفون: Kerstin Jahn-Hofmann, Joerg F. Schlaak, G. Gerken, K Kleinehr, Matthias John, R Bröring, L Ickenstein, CI Real

    المصدر: Zeitschrift für Gastroenterologie. 50

    مصطلحات موضوعية: chemistry.chemical_compound, Small interfering RNA, Immune system, chemistry, Biochemistry, In vivo, Ribose, Gastroenterology, Biology, Receptor

    الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::216689b40babfbc562bd05cca70d3504Test
    https://doi.org/10.1055/s-0031-1295929Test


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  10. 10
    In Vivo Treatment With Nanolipid-Formulated siRNAs Targeting ISG15 Leads to Enhanced TLR-Induced Expression of Interferon-Sensitive Genes in Hepatocytes

    المؤلفون: Matthias John, K Kleinehr, CI Real, Joerg F. Schlaak, Guido Gerken, R Bröring

    مصطلحات موضوعية: Small interfering RNA, Hepatology, Chemistry, In vivo, Interferon, Gastroenterology, medicine, Medizin, ISG15, Gene, Cell biology, medicine.drug

    الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59929c4b7ca9a1ac0be78330d372b9caTest


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