المؤلفون: Becky A.S. Bibby, Ronnie Rodrigues Pereira, Ananya Choudhury, Kaye J. Williams, Elisabet More, Darragh G. McArt, Robert G. Bristow, Paul G. O’Reilly, N. Thiruthaneeswaran, Catharine M L West, Lingjian Yang

المصدر: Bibby, B A S, Thiruthaneeswaran, N, Yang, L, Pereira, R R, More, E, McArt, D G, O'Reilly, P, Bristow, R G, Williams, K J, Choudhury, A & West, C M L 2021, ' Repurposing FDA approved drugs as radiosensitizers for treating hypoxic prostate cancer ', BMC urology, vol. 21, no. 1, 96 . https://doi.org/10.1186/s12894-021-00856-xTest
BMC Urology
Bibby, B A S, Thiruthaneeswaran, N, Yang, L, Pereira, R R, More, E, McArt, D G, O'Reilly, P, Bristow, R G, Williams, K J, Choudhury, A & West, C M L 2021, ' Repurposing FDA approved drugs as radiosensitizers for treating hypoxic prostate cancer ', BMC Urology, vol. 21, no. 1, pp. 96 . https://doi.org/10.1186/s12894-021-00856-xTest
BMC Urology, Vol 21, Iss 1, Pp 1-11 (2021)

مصطلحات موضوعية: 0301 basic medicine, Male, Radiation-Sensitizing Agents, Urology, 03 medical and health sciences, Prostate cancer, chemistry.chemical_compound, 0302 clinical medicine, Menadione, DU145, SDG 3 - Good Health and Well-being, Radioresistance, Cell Line, Tumor, LNCaP, Medicine, Humans, Clonogenic assay, Hypoxia, Manchester Cancer Research Centre, business.industry, United States Food and Drug Administration, ResearchInstitutes_Networks_Beacons/mcrc, Drug Repositioning, Prostatic Neoplasms, General Medicine, Hypoxia (medical), medicine.disease, Gemcitabine, Diseases of the genitourinary system. Urology, United States, 030104 developmental biology, Reproductive Medicine, chemistry, 030220 oncology & carcinogenesis, Cancer research, RC870-923, medicine.symptom, business, medicine.drug, Research Article

وصف الملف: application/vnd.openxmlformats-officedocument.wordprocessingml.document; application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96352efa42d651655e10ac31beee7b74Test
https://pure.manchester.ac.uk/ws/files/196449568/s12894_021_00856_x.pdfTest

المؤلفون: Maria Likhatcheva, Roben G. Gieling, James A. L. Brown, Constantinos Demonacos, Kaye J. Williams

المصدر: Frontiers in Cell and Developmental Biology
Likhatcheva, M, Gieling, R G, Brown, J A L, Demonacos, C & Williams, K J 2021, ' A Novel Mechanism of Ataxia Telangiectasia Mutated Mediated Regulation of Chromatin Remodeling in Hypoxic Conditions ', Frontiers in cell and developmental biology, vol. 9, 720194 . https://doi.org/10.3389/fcell.2021.720194Test
Frontiers in Cell and Developmental Biology, Vol 9 (2021)

مصطلحات موضوعية: Methyltransferase, QH301-705.5, SUV39H1, Chromatin remodeling, Cell and Developmental Biology, MDM2, medicine, Epigenetics, Ataxia Telangiectasia Mutated (ATM), Biology (General), Original Research, biology, Kinase, Chemistry, hypoxia, C100, C500, Cell Biology, Hypoxia (medical), Cell biology, Histone, Tip60, biology.protein, Mdm2, medicine.symptom, Developmental Biology

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9672b25273a95a83e12e04976a2f0900Test
https://pubmed.ncbi.nlm.nih.gov/34621741Test

المؤلفون: Marianne Ashford, Ian J. Stratford, Julio M. Rios de la Rosa, Alice Spadea, Nicola Tirelli, Manal Mehibel, Annalisa Tirella, Kaye J. Williams

المصدر: Molecular Pharmaceutics. 16:2481-2493

مصطلحات موضوعية: Gene isoform, media_common.quotation_subject, Cell, Pharmaceutical Science, 02 engineering and technology, Biology, 030226 pharmacology & pharmacy, 03 medical and health sciences, chemistry.chemical_compound, Drug Delivery Systems, 0302 clinical medicine, Cell Line, Tumor, Drug Discovery, Hyaluronic acid, medicine, Humans, Hyaluronic Acid, Receptor, Internalization, media_common, CD44, Cancer, Flow Cytometry, 021001 nanoscience & nanotechnology, medicine.disease, Immunohistochemistry, 3. Good health, Hyaluronan Receptors, medicine.anatomical_structure, chemistry, Cancer cell, biology.protein, Cancer research, Molecular Medicine, 0210 nano-technology

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d95e7d6baf0e17192457056c7c67ee96Test
https://doi.org/10.1021/acs.molpharmaceut.9b00083Test

المؤلفون: Emmy Hoyes, Emmanuelle Claude, Kaye J. Williams, Joanna Denbigh, Lidan Christie, Adam McMahon, Fiona Henderson, Emrys A. Jones, Richard Chapman, Federico Roncaroli

المصدر: Scientific Reports, Vol 10, Iss 1, Pp 1-7 (2020)
Scientific Reports
Henderson, F, Jones, E, Denbigh, J, Christie, L, Chapman, R, Hoyes, E, Claude, E, Williams, K, Roncaroli, F & McMahon, A 2020, ' 3D DESI-MS lipid imaging in a xenograft model of glioblastoma: a proof of principle ', Scientific Reports, vol. 10, 16512 (2020) . https://doi.org/10.1038/s41598-020-73518-xTest

مصطلحات موضوعية: Diagnostic Imaging, Spectrometry, Mass, Electrospray Ionization, Tumour heterogeneity, medicine.medical_treatment, Mice, Nude, lcsh:Medicine, Diseases, Immunofluorescence, Proof of Concept Study, Biochemistry, Article, Mice, Imaging, Three-Dimensional, Medical research, medicine, Animals, Treatment resistance, lcsh:Science, Cancer, Multidisciplinary, medicine.diagnostic_test, Chemistry, Biological techniques, lcsh:R, Lipid metabolism, Lipid Metabolism, medicine.disease, Lipids, Xenograft Model Antitumor Assays, Staining, Radiation therapy, Disease Models, Animal, Tissue sections, Oncology, Cancer research, Heterografts, Female, lcsh:Q, Glioblastoma, Biomarkers

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::643732f3e557b2fbd565a94d6d1d87f6Test
https://doi.org/10.1038/s41598-020-73518-xTest

المؤلفون: Kaye J. Williams, Roben G. Gieling

المصدر: International Journal of Molecular Sciences

مصطلحات موضوعية: 0301 basic medicine, Gene isoform, Review, CAIX/XII inhibitors, Catalysis, S4, Inorganic Chemistry, 03 medical and health sciences, Structure-Activity Relationship, 0302 clinical medicine, Breast cancer, Downregulation and upregulation, medicine, Humans, Physical and Theoretical Chemistry, Carbonic Anhydrase IX, Carbonic Anhydrase Inhibitors, Molecular Biology, Spectroscopy, Carbonic Anhydrases, Cisplatin, chemistry.chemical_classification, Sulfonamides, hypoxia, U-104, Phenylurea Compounds, Organic Chemistry, Sulfonamide (medicine), C100, ureido-substituted sulfamate, General Medicine, medicine.disease, C700, Small Cell Lung Carcinoma, 3. Good health, Computer Science Applications, B900, 030104 developmental biology, Enzyme, chemistry, 030220 oncology & carcinogenesis, Cancer cell, Cancer research, ureido-substituted benzenesulfonamide, Sulfonic Acids, SLC-0111, medicine.drug, carbonic anhydrases (CAs)

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1700d8ff8595447ec0bb0f4c59cbb76Test

المؤلفون: Jesús M. Pradillo, Hervé Boutin, Fiona Henderson, Michael Kassiou, Philippa J. Hart, Lidan Christie, Adam McMahon, Kaye J. Williams

المصدر: Henderson, F, Hart, P J, Pradillo, J M, Kassiou, M, Christie, L, Williams, K J, Boutin, H & McMahon, A 2018, ' Multi-modal imaging of long-term recovery post-stroke by positron emission tomography and matrix-assisted laser desorption/ionisation mass spectrometry ', Rapid Communications in Mass Spectrometry, vol. 32, no. 9, pp. 721-729 . https://doi.org/10.1002/rcm.8090Test

مصطلحات موضوعية: 0301 basic medicine, Time Factors, medicine.medical_treatment, Mass spectrometry, Mass spectrometry imaging, Analytical Chemistry, 03 medical and health sciences, 0302 clinical medicine, Nuclear magnetic resonance, In vivo, Journal Article, medicine, Animals, Rats, Wistar, Stroke, Spectroscopy, Neuroinflammation, medicine.diagnostic_test, Chemistry, Organic Chemistry, Brain, Lysophosphatidylcholines, Magnetic resonance imaging, medicine.disease, Magnetic Resonance Imaging, Sphingomyelins, Pyrimidines, 030104 developmental biology, Positron emission tomography, Positron-Emission Tomography, Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization, Phosphatidylcholines, Pyrazoles, Stroke recovery, 030217 neurology & neurosurgery

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a94233abd14037a23a7b12ba73b0ec7Test
https://doi.org/10.1002/rcm.8090Test

المؤلفون: Caroline Kelly, Karin Williams, Stephen T. Durant, Sarah Derby, Kaye J. Williams, Rodrigo Gutierrez-Quintana, Anthony J. Chalmers, Mark R. Jackson, Jon Stobo, David Walker, Lorna Sweeting, Duncan Forster

المصدر: Clinical Cancer Research. 27:IA-006

مصطلحات موضوعية: Oncology, Cancer Research, medicine.medical_specialty, Temozolomide, Performance status, business.industry, medicine.medical_treatment, Brain tumor, Phases of clinical research, Cancer, medicine.disease, Olaparib, Radiation therapy, chemistry.chemical_compound, Therapeutic index, chemistry, Internal medicine, medicine, business, medicine.drug

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::54e2112bab2e989e3e09e26abc9ea0b1Test
https://doi.org/10.1158/1557-3265.radsci21-ia-006Test

المؤلفون: Timothy W. Wallace, John A. Hadfield, Steven B. Rossington, Kaye J. Williams, Steven D. Shnyder

المصدر: Rossington, S, Hadfield, J, Shnyder, S D, Wallace, T & Williams, K 2017, ' Tubulin-binding dibenz[c,e]oxepines : Part 2. Structural variation and biological evaluation as tumour vasculature disrupting agents ', Bioorganic and Medicinal Chemistry, vol. 25, no. 5, pp. 1630-1642 . https://doi.org/10.1016Test/j.bmc.2017.01.027

مصطلحات موضوعية: Necrosis, Clinical Biochemistry, Pharmaceutical Science, Tumour vasculature, 01 natural sciences, Biochemistry, Tubulin binding, Structural variation, Mice, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Tubulin, Cell Line, Tumor, Neoplasms, Biological property, Drug Discovery, Journal Article, medicine, Animals, Humans, Colchicine, Molecular Biology, Biological evaluation, Dose-Response Relationship, Drug, Molecular Structure, biology, 010405 organic chemistry, direct arylation, Organic Chemistry, palladium catalyst, 0104 chemical sciences, tubulin, chemistry, Cell culture, 030220 oncology & carcinogenesis, biology.protein, Heterografts, Molecular Medicine, medicine.symptom, Dibenzoxepins

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7159b0428917a521e7ecb361504f199Test
https://doi.org/10.1016Test/j.bmc.2017.01.027

المؤلفون: Andrew P. Badrock, Jivko Kamarashev, Irene Barinaga-Rementeria Ramirez, Duncan Forster, Katherine A. Hollywood, Emmanuelle Claude, Adam Hurlstone, B. Ewa Snaar-Jagalska, Michael Green, Herman P. Spaink, Adam McMahon, Christos Evangelou, Hannah R Johnston, Warwick B. Dunn, Michael Fairclough, Shuning He, Fiona Henderson, Kaye J. Williams, Paul Lorigan, Michael P. Smith, Raghavendar Nagaraju, Emrys A. Jones

المصدر: Henderson, F, Johnston, H, Badrock, A, Jones, E, Forster, D, Nagaraju, R, Evangelou, C, Kamarashev, J, Green, M, Fairclough, M, Barinaga-Rementeria, I, He, S, Jagalska, E S, Hollywood, K, Dunn, W, Spaink, H P, Smith, M, Lorigan, P, Claude, E, Williams, K, Mcmahon, A & Hurlstone, A 2019, ' Enhanced fatty acid scavenging and glycerophospholipid metabolism accompanies melanocyte neoplasia progression in zebrafish ', Cancer Research, vol. 79, no. 9, pp. 2136-2151 . https://doi.org/10.1158/0008-5472.can-18-2409Test
Cancer Research, 79(9), 2136-2151
Cancer Research

مصطلحات موضوعية: 0301 basic medicine, Cancer Research, Phospholipid, Glycerophospholipids, Palmitic acid, Transcriptome, Mass Spectrometry Imaging, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Manchester Institute of Biotechnology, Tumor Cells, Cultured, Animals, Humans, Metabolomics, Zebrafish, Melanoma, chemistry.chemical_classification, Lipoprotein lipase, Microphthalmia-Associated Transcription Factor, biology, Fatty Acids, Fatty acid, Lipid metabolism, Zebrafish Proteins, biology.organism_classification, Lipid Metabolism, ResearchInstitutes_Networks_Beacons/manchester_institute_of_biotechnology, Fatty acid synthase, Lipoprotein Lipase, 030104 developmental biology, Oncology, chemistry, 030220 oncology & carcinogenesis, Cancer research, biology.protein, ras Proteins, Melanocytes, LPL, Fatty Acid Synthases, Energy Metabolism, Transcriptome Analysis, Fatty Acid

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b3528b41f2ca92becf293b08a708b55Test
https://pubmed.ncbi.nlm.nih.gov/30862716Test

المؤلفون: D. Walker, Kaye J. Williams, R. Gutierrez-Quintana, N. Gomez-Roman, Anthony J. Chalmers, S.T. Durant

المصدر: Radiotherapy and Oncology. 152:S311

مصطلحات موضوعية: chemistry.chemical_compound, Oncology, chemistry, Radiology, Nuclear Medicine and imaging, Hematology, Penetrant (biochemical), Neural stem cell, Cell biology

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::f030d46bb4776123674f7db8f3076280Test
https://doi.org/10.1016/s0167-8140Test(21)00580-6