دورية أكاديمية
Necrotizing Follicular Lymphoma of the Inguinal Region with Sternbergoid Cells: Clinical–Pathological Features of a Challenging Entity
| العنوان: | Necrotizing Follicular Lymphoma of the Inguinal Region with Sternbergoid Cells: Clinical–Pathological Features of a Challenging Entity |
|---|---|
| المؤلفون: | Federico Scarmozzino, Marco Pizzi, Marta Sbaraglia, Luisa Santoro, Luca Frison, Silvia Nalio, Laura Bonaldi, Livio Trentin, Angelo Paolo Dei Tos |
| المصدر: | Applied Sciences, Vol 12, Iss 3, p 1290 (2022) |
| بيانات النشر: | MDPI AG, 2022. |
| سنة النشر: | 2022 |
| المجموعة: | LCC:Technology LCC:Engineering (General). Civil engineering (General) LCC:Biology (General) LCC:Physics LCC:Chemistry |
| مصطلحات موضوعية: | follicular lymphoma, diffuse large B-cell lymphoma, necrotizing lymphadenopathy, Hodgkin/Reed–Sternberg-like cells, histopathology, Technology, Engineering (General). Civil engineering (General), TA1-2040, Biology (General), QH301-705.5, Physics, QC1-999, Chemistry, QD1-999 |
| الوصف: | Follicular lymphoma (FL) is one of the most common B-cell malignancies worldwide. While the diagnosis of conventional cases is straightforward, rare clinical–pathological variants may be challenging due to their misleading morphology, aberrant phenotype and/or atypical presentation. To add to the spectrum of unusual FLs, we report on a rare disease pattern characterized by (i) inguinal presentation, (ii) massive necrosis, (iii) Hodgkin/Reed–Sternberg (HRS)-like cells, and (iv) adjacent areas of diffuse large B-cell lymphoma evolution. All cases occurred in elderly patients (median age at diagnosis: 69.5 years), disclosed a low stage at diagnosis (Ann Arbor stage IA-IIA), and had deceiving clinical features. Despite the alarming histology, excellent responses to conventional therapies were reported in all patients. In conclusion, necrotizing FL of the inguinal region is a rare neoplasm characterized by peculiar clinical and histological features. This lymphoma should always be considered in the differential diagnosis of massively necrotic inguinal lesions. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2076-3417 |
| العلاقة: | https://www.mdpi.com/2076-3417/12/3/1290Test; https://doaj.org/toc/2076-3417Test |
| DOI: | 10.3390/app12031290 |
| الوصول الحر: | https://doaj.org/article/7771f0c279f1400b99f18a6012309ed2Test |
| رقم الانضمام: | edsdoj.7771f0c279f1400b99f18a6012309ed2 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 20763417 |
|---|---|
| DOI: | 10.3390/app12031290 |