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1
المؤلفون: David Longmire, Haley Woods, Phillip B Rawlins, Jessie Hao-Ru Hsu, Daniel H O' Donovan, Alexandra Borodovsky, Peng Wang, Sharan K Bagal, Shaun M Fillery, Peter Barton, Clare Gregson, Beth Williamson, Samuel C Nash, Andrew Pike, Jon A Read, Kurt Gordon Pike, Andrew Bloecher, Erin Code, Minhui Shen, Sameer Kawatkar, Youfeng Nai, Jia Tang, Chengzhi Li, James C. Robinson
المصدر: Journal of Medicinal Chemistry. 64:17146-17183
مصطلحات موضوعية: Methyltransferase, Protein subunit, Allosteric regulation, macromolecular substances, Ligands, Cell Line, Structure-Activity Relationship, Allosteric Regulation, Heterocyclic Compounds, Catalytic Domain, Drug Discovery, Animals, Humans, Enhancer of Zeste Homolog 2 Protein, Enzyme Inhibitors, Enhancer, Cell Proliferation, biology, Chemistry, EZH2, Polycomb Repressive Complex 2, Small molecule, Rats, Histone methyltransferase, biology.protein, Cancer research, Molecular Medicine, PRC2
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cfbef686d9310c0393124b8f8df7ca38Test
https://doi.org/10.1021/acs.jmedchem.1c01161Test -
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المؤلفون: Edward J. Hennessy, Marianne Schimpl, Emma Rivers, Paul D. Smith, Elizabeth Hardaker, Ann T. Doherty, Nichola L. Davies, Jon Travers, Qianxiu Zhu, Beth Williamson, Graham Smith, Lorraine Mooney, Helen Musgrove, Kristin Goldberg, Muireann Coen, Anne-Laure Lainé, Xiefeng Jiang, Philip Hopcroft, Yuting Zheng, Robert I Troup, George Hodgson, Nicola Lindsay, Lindsay McMurray, Olga Collingwood, Stephen D. Wilkinson, Sharon Tentarelli, Guang He, Philip B. Rawlins, Roshini Markandu, Jon Winter-Holt, Josephine Walton, Ankur Karmokar, J. Willem M. Nissink, Yumeng Mao, Dejian Yang, Alexander Pflug, Gary Fairley, Scott Boyd, Cheng Wang, Anne Jackson, Martin R. Brown, William McCoull, Neville McLean, Venkatesh Pilla Reddy
المصدر: Journal of Medicinal Chemistry. 64:13524-13539
مصطلحات موضوعية: chemistry.chemical_compound, Tumor microenvironment, Innate immune system, Chemistry, Kinase, In vivo, Drug Discovery, Pyridine, Lipophilicity, Cancer research, Molecular Medicine, Potency, Compound 32
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::ae4c719e098004f12a5992670f8e8abcTest
https://doi.org/10.1021/acs.jmedchem.1c00920Test -
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المؤلفون: Katherine Fenner, Abhishek Srivastava, Beth Williamson, Andrew Pike
المصدر: Journal of Pharmaceutical Sciences. 110:1412-1417
مصطلحات موضوعية: Pharmaceutical Science, Excipient, 02 engineering and technology, 030226 pharmacology & pharmacy, Dialysis tubing, 03 medical and health sciences, 0302 clinical medicine, Renal Dialysis, medicine, Humans, Drug Interactions, Equilibrium dialysis, Solubility, ADME, Chromatography, Chemistry, Blood Proteins, 021001 nanoscience & nanotechnology, Pharmaceutical Preparations, Free fraction, Lipophilicity, Lipinski's rule of five, 0210 nano-technology, Dialysis, Protein Binding, medicine.drug
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74ce67d843a0379d03045dc1f7d6ae4bTest
https://doi.org/10.1016/j.xphs.2020.11.018Test -
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المؤلفون: Dermot F. McGinnity, Beth Williamson, Stephanie Harlfinger
المصدر: Drug Metabolism and Disposition. 48:1137-1146
مصطلحات موضوعية: Male, Drug Evaluation, Preclinical, Extrapolation, Datasets as Topic, Pharmaceutical Science, Pharmacology, Models, Biological, 030226 pharmacology & pharmacy, 03 medical and health sciences, 0302 clinical medicine, medicine, Cytochrome P-450 CYP3A, Humans, In vitro in vivo, Human liver, Chemistry, Target engagement, Recombinant Proteins, Hepatobiliary Elimination, medicine.anatomical_structure, Liver, 030220 oncology & carcinogenesis, Hepatocyte, Hepatocytes, Microsomes, Liver, Microsome, Female, Drug metabolism, Oral retinoid
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77ee63503e9e698986d5025960432a99Test
https://doi.org/10.1124/dmd.120.000131Test -
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المؤلفون: Simone H. Stahl, Johan X. Johansson, Beth Williamson, Katherine Fenner, Ravindra V. Alluri, Jason Grant Kettle, M. Raymond V. Finlay
المصدر: The Medicinal Chemist's Guide to Solving ADMET Challenges ISBN: 9781788012270
مصطلحات موضوعية: Biochemistry, Chemistry, Endogeny, Membrane Transporters, Transporter, Tissue distribution, Apical membrane, Uptake transporters
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::f7579fba6de75407df41eb9b2bc4de65Test
https://doi.org/10.1039/9781788016414-00062Test -
6
المؤلفون: Sameer Kawatkar, Philip B. Rawlins, Kurt Gordon Pike, Jessie Hao-Ru Hsu, Shaun M. Fillery, Clare Gregson, Minhui Shen, Daniel H. O' Donovan, Martin J. Packer, Jon Read, S. Bagal, Andrew Bloecher, Beth Williamson, James Robinson, Peter Barton, Ryan Greenwood, Erin Code, Haley Woods
المصدر: Bioorganic & Medicinal Chemistry Letters. 39:127904
مصطلحات موضوعية: Methyltransferase, Protein subunit, Clinical Biochemistry, Pharmaceutical Science, Ligands, 01 natural sciences, Biochemistry, Free energy perturbation, Structure-Activity Relationship, Drug Discovery, Humans, Enzyme Inhibitors, Binding site, Molecular Biology, Dose-Response Relationship, Drug, Molecular Structure, biology, 010405 organic chemistry, Chemistry, Ligand, Organic Chemistry, EZH2, Polycomb Repressive Complex 2, Combinatorial chemistry, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, Purines, Drug Design, Microsomes, Liver, biology.protein, Quantum Theory, Thermodynamics, Molecular Medicine, PRC2
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b19eb341b997e66a555f392e58836843Test
https://doi.org/10.1016/j.bmcl.2021.127904Test -
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المؤلفون: Beth Williamson, Patrick Barton, Paul Lancett, Robert J. Riley
المصدر: Drug metabolism and disposition: the biological fate of chemicals. 46(8)
مصطلحات موضوعية: 0301 basic medicine, Metabolic Clearance Rate, Pharmaceutical Science, Pharmacology, 030226 pharmacology & pharmacy, 03 medical and health sciences, 0302 clinical medicine, Pharmacokinetics, Cytochrome P-450 Enzyme System, In vivo, Drug Discovery, Potency, Distribution (pharmacology), Humans, RNA, Messenger, Glucuronosyltransferase, Cells, Cultured, biology, Chemistry, Drug discovery, Cytochrome P450, In vitro, Kinetics, 030104 developmental biology, Liver, Toxicity, biology.protein, Hepatocytes, Biological Assay
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f5077201af61743cce7568418f21778Test
https://pubmed.ncbi.nlm.nih.gov/29880630Test -
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المؤلفون: Claire E. Wilson, Robert J. Riley, Gayle Dagnell, Beth Williamson
المصدر: Journal of pharmacological and toxicological methods. 84
مصطلحات موضوعية: 0301 basic medicine, Computational biology, Pharmacology, Toxicology, Rats, Sprague-Dawley, 03 medical and health sciences, Mice, Pharmacokinetics, Species Specificity, In vivo, High-Throughput Screening Assays, Animals, Humans, Rats, Wistar, ADME, Chemistry, Drug discovery, In vitro toxicology, In vitro, Rats, Mice, Inbred C57BL, 030104 developmental biology, Microsome, Microsomes, Liver
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f96ab9338e673b89673a450ff1fa4f5Test
https://pubmed.ncbi.nlm.nih.gov/27773845Test -
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المؤلفون: Beth Williamson, Yuan Zhang, David Back, Andrew Owen, Kelly E. Dooley
المصدر: Antimicrobial Agents and Chemotherapy. 57:6366-6369
مصطلحات موضوعية: ATP Binding Cassette Transporter, Subfamily B, Rifabutin, ATP-binding cassette transporter, Pharmacology, polycyclic compounds, medicine, Cytochrome P-450 CYP3A, Humans, Pharmacology (medical), ATP Binding Cassette Transporter, Subfamily B, Member 1, Cells, Cultured, biology, CYP3A4, Chemistry, Multidrug resistance-associated protein 2, Membrane Transport Proteins, Cytochrome P450, Transporter, Rifapentine, Multidrug Resistance-Associated Protein 2, Infectious Diseases, Hepatocytes, biology.protein, ABCC1, Multidrug Resistance-Associated Proteins, Rifampin, medicine.drug
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d5ddcdef4883758e22beb4efcbdcce8Test
https://doi.org/10.1128/aac.01124-13Test -
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المؤلفون: Andrew Owen, Matthew G. Soars, Robert J. Riley, A C Soars, Beth Williamson, Peter White
المصدر: Xenobiotica. 43:920-931
مصطلحات موضوعية: Male, Estrone, Health, Toxicology and Mutagenesis, Molecular Sequence Data, Organic Anion Transporters, Tetrazoles, Pharmacology, Toxicology, Biochemistry, Xenobiotics, chemistry.chemical_compound, medicine, Cytochrome P-450 CYP3A, Humans, Drug Interactions, RNA, Small Interfering, Rosuvastatin Calcium, Pitavastatin, Cells, Cultured, Sulfonamides, Base Sequence, biology, Liver-Specific Organic Anion Transporter 1, Chemistry, Imidazoles, Cytochrome P450, Valine, Transporter, General Medicine, Fluorobenzenes, Organic anion-transporting polypeptide, Pyrimidines, Nuclear receptor, Toxicity, Hepatocytes, Quinolines, biology.protein, Valsartan, Female, Xenobiotic, medicine.drug
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::159ba9c4f9ab41047d27d47a0d2abfc8Test
https://doi.org/10.3109/00498254.2013.776194Test