نتائج البحث - "Receptors, Neuropeptide Y"

1

Design and Evaluation of Peptide Dual-Agonists of GLP-1 and NPY2 Receptors for Glucoregulation and Weight Loss with Mitigated Nausea and Emesis

المؤلفون: Christian L. Roth, Oleg G. Chepurny, Bart C. De Jonghe, George G. Holz, Clinton Elfers, Kylie S. Chichura, Matthew R. Hayes, Tito Borner, Robert P. Doyle, Ian R. Sweet, Brandon T. Milliken

المصدر: J Med Chem

مصطلحات موضوعية: Blood Glucose, Male, Models, Molecular, Vomiting, Nausea, Neuropeptide, Peptide, Type 2 diabetes, Pharmacology, Binding, Competitive, 01 natural sciences, Article, Glucagon-Like Peptide-1 Receptor, Rats, Sprague-Dawley, Islets of Langerhans, Structure-Activity Relationship, 03 medical and health sciences, Weight loss, In vivo, Insulin Secretion, Weight Loss, Drug Discovery, medicine, Animals, Humans, Peptide YY, Receptor, 030304 developmental biology, chemistry.chemical_classification, 0303 health sciences, Shrews, medicine.disease, In vitro, Rats, Receptors, Neuropeptide Y, 0104 chemical sciences, Molecular Docking Simulation, 010404 medicinal & biomolecular chemistry, Glucose, chemistry, Microsomes, Liver, Exenatide, Molecular Medicine, medicine.symptom

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f87628e79fa1735fd176ff82760e989Test
https://doi.org/10.1021/acs.jmedchem.0c01783Test

2

Tautomycetin Synthetic Analogues: Selective Inhibitors of Protein Phosphatase I

المؤلفون: A. Richard Chamberlin, A. John Yucel, Zachary R. Woydziak

المصدر: ChemMedChem

مصطلحات موضوعية: animal structures, Stereochemistry, Phosphatase, macromolecular substances, environment and public health, 01 natural sciences, Biochemistry, Article, Serine, Structure-Activity Relationship, chemistry.chemical_compound, Drug Discovery, Humans, Protein Phosphatase 2, Enzyme Inhibitors, General Pharmacology, Toxicology and Pharmaceutics, Threonine, Furans, IC50, Pharmacology, Dose-Response Relationship, Drug, Molecular Structure, biology, 010405 organic chemistry, Chemistry, Organic Chemistry, Active site, Protein phosphatase 2, Lipids, Receptors, Neuropeptide Y, 0104 chemical sciences, enzymes and coenzymes (carbohydrates), 010404 medicinal & biomolecular chemistry, embryonic structures, biology.protein, Molecular Medicine, Tautomycin, Selectivity

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c41f38ec9e6986e89eb3b1be678f627Test
https://doi.org/10.1002/cmdc.202000801Test

3

NPY1R-targeted peptide-mediated delivery of a dual PPARα/γ agonist to adipocytes enhances adipogenesis and prevents diabetes progression

المؤلفون: Nora Klöting, Stefanie Wittrisch, Annette G. Beck-Sickinger, Matthias Blüher, Karin Mörl, Rima Chakaroun

المصدر: Molecular Metabolism
Molecular Metabolism, Vol 31, Iss, Pp 163-180 (2020)
Mol. Metab. 31, 163-180 (2020)

مصطلحات موضوعية: 0301 basic medicine, Molecular Conformation, Adipose tissue, Pharmacology, Adipocyte Targeting, Npy1r, Peptide Drug Conjugate, Tesaglitazar, Type 2 Diabetes, Mice, chemistry.chemical_compound, 0302 clinical medicine, tesa, tesaglitazar, Adipocyte, Chlorocebus aethiops, Adipocytes, FFA, free fatty acids, Cells, Cultured, Adipogenesis, Phenylpropionates, Cell Differentiation, Adipocyte targeting, Type 2 diabetes, NPY1R, neuropeptide Y1 receptor, tesa-NPY, [K4(GFLG-tesa), F7, P34]-NPY, Fabp4, fatty acid binding protein 4, NPY1R, COS Cells, Female, Original Article, Alkanesulfonates, Agonist, lcsh:Internal medicine, Cell type, medicine.drug_class, NPY, neuropeptide Y, T2D, type 2 diabetes, 030209 endocrinology & metabolism, Diabetes Mellitus, Experimental, Structure-Activity Relationship, 03 medical and health sciences, 3T3-L1 Cells, medicine, Animals, Humans, PPAR alpha, lcsh:RC31-1245, Molecular Biology, GPCR, G protein-coupled receptor, Mcp-1, monocyte chemotactic protein, Dose-Response Relationship, Drug, Adiponectin, Cell Biology, PPARα/γ, peroxisome proliferator-activated receptor alpha/gamma, Receptors, Neuropeptide Y, Mice, Inbred C57BL, PPAR gamma, HEK293 Cells, 030104 developmental biology, Diabetes Mellitus, Type 2, chemistry, Cell culture, Peptides, Cidec, cell death-inducing DEFA-like effector c, Peptide drug conjugate

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e8a5984d3babe4cd79f900f950e2c37Test
https://doi.org/10.1016/j.molmet.2019.11.009Test

4

Probing the Y2 Receptor on Transmembrane, Intra- and Extra-Cellular Sites for EPR Measurements

المؤلفون: Dariush Hinderberger, Peter Schmidt, Annette G. Beck-Sickinger, Anette Kaiser, Jeannette M Laugwitz, Haleh H. Haeri, Ulrike Krug

المصدر: Molecules
Molecules, Vol 25, Iss 4143, p 4143 (2020)
Volume 25
Issue 18

مصطلحات موضوعية: Models, Molecular, Protein Conformation, Intracellular Space, Pharmaceutical Science, Gene Expression, IDSL, 01 natural sciences, Analytical Chemistry, law.invention, refolding, chemistry.chemical_compound, GPCR, law, Drug Discovery, Electron paramagnetic resonance, Promoter Regions, Genetic, 0303 health sciences, Chemistry, Transmembrane protein, Chemistry (miscellaneous), ddc:540, Molecular Medicine, MTSL, Transcriptional Activation, Nitroxide mediated radical polymerization, DEER, Article, lcsh:QD241-441, 03 medical and health sciences, Structure-Activity Relationship, lcsh:Organic chemistry, Humans, Amino Acid Sequence, Cysteine, Physical and Theoretical Chemistry, Y2R, EPR, nitroxide spin labels, 030304 developmental biology, G protein-coupled receptor, 010405 organic chemistry, Pulsed EPR, Organic Chemistry, Cell Membrane, Electron Spin Resonance Spectroscopy, Site-directed spin labeling, 0104 chemical sciences, Receptors, Neuropeptide Y, HEK293 Cells, Biophysics, Mutagenesis, Site-Directed, Biomarkers

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6d7351ce04c4c84e9d72d03732bd569Test
http://europepmc.org/articles/PMC7571237Test

5

The Dynamics of the Neuropeptide Y Receptor Type 1 Investigated by Solid-State NMR and Molecular Dynamics Simulation

المؤلفون: Annette G. Beck-Sickinger, Peter Schmidt, Sarah Wistuba, Mathias Bosse, Alexander Vogel, Peter W. Hildebrand, Marcel Gauglitz, Daniel Huster, Vsevolod V. Gurevich, Anette Kaiser

المصدر: Molecules
Molecules, Vol 25, Iss 5489, p 5489 (2020)
Volume 25
Issue 23

مصطلحات موضوعية: Magnetic Resonance Spectroscopy, Protein Conformation, Pharmaceutical Science, Molecular Dynamics Simulation, 010402 general chemistry, Neuropeptide Y Receptor Type 1, 01 natural sciences, Article, Analytical Chemistry, lcsh:QD241-441, 03 medical and health sciences, Molecular dynamics, Structure-Activity Relationship, GPCR, NMR spectroscopy, lcsh:Organic chemistry, Drug Discovery, Physical and Theoretical Chemistry, Lipid bilayer, Nuclear Magnetic Resonance, Biomolecular, 030304 developmental biology, Molecular switch, 0303 health sciences, Chemistry, arrestin, Organic Chemistry, MD simulation, Nuclear magnetic resonance spectroscopy, 500 Naturwissenschaften und Mathematik::570 Biowissenschaften, Biologie::570 Biowissenschaften, Biologie, structural dynamics, Recombinant Proteins, 0104 chemical sciences, Receptors, Neuropeptide Y, molecular switch, Transmembrane domain, Solid-state nuclear magnetic resonance, Chemistry (miscellaneous), Helix, Biophysics, Molecular Medicine

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e4779e26d0088fb0f381f41cefdaab60Test

6

The antibiotic robenidine exhibits guanabenz-like cytoprotective properties by a mechanism independent of protein phosphatase PP1:PPP1R15A

المؤلفون: Mathieu Bollen, Marloes C. M. Jonkhout, Ana Crespillo-Casado, Zander Claes

المصدر: J Biol Chem

مصطلحات موضوعية: 0301 basic medicine, Drug action, Pharmacology, Biochemistry, guanabenz, robenidine, chemistry.chemical_compound, neurodegenerative disease, Protein Phosphatase 1, protein phosphatase 1 (PP1), drug action, unfolded protein response (UPR), Cells, Cultured, biology, Cell Cycle, protein phosphatase, bioluminescence, Anti-Bacterial Agents, Enzyme inhibitor, Tumor necrosis factor alpha, Guanabenz, medicine.drug, Robenidine, protein phosphatase 1 regulatory subunit 15A (PPP1R15A), Phosphatase, enzyme inhibitor, CHO Cells, Protective Agents, biosensor, 03 medical and health sciences, Structure-Activity Relationship, Cricetulus, medicine, Structure–activity relationship, Animals, Humans, Molecular Biology, Cell Proliferation, 030102 biochemistry & molecular biology, Dose-Response Relationship, Drug, Cell Biology, Receptors, Neuropeptide Y, 030104 developmental biology, HEK293 Cells, cell proliferation, chemistry, eukaryotic initiation factor 2 (eIF2), biology.protein, Unfolded protein response, endoplasmic reticulum stress (ER stress), HeLa Cells

وصف الملف: Print-Electronic

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9852fbd7b5e70a238780e585f47be15Test
https://lirias.kuleuven.be/handle/123456789/639893Test

7

Structural basis of ligand binding modes at the neuropeptide Y Y1 receptor

المصدر: Nature

مصطلحات موضوعية: 0301 basic medicine, Agonist, Dihydropyridines, medicine.drug_class, Inositol Phosphates, Arginine, Crystallography, X-Ray, Ligands, Article, Substrate Specificity, Structure-Activity Relationship, 03 medical and health sciences, medicine, Humans, Neuropeptide Y, Receptor, Diphenylacetic Acids, Nuclear Magnetic Resonance, Biomolecular, Binding Sites, Multidisciplinary, 030102 biochemistry & molecular biology, Drug discovery, Chemistry, Phenylurea Compounds, Neuropeptide Y receptor, Ligand (biochemistry), Receptors, Neuropeptide Y, 3. Good health, Molecular Docking Simulation, N-terminus, 030104 developmental biology, Biochemistry, Peptide YY, Mutation, Mutant Proteins, Endogenous agonist, Protein Binding

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35c7c85e188410a47148a2b5ceedc71fTest
https://doi.org/10.1038/s41586-018-0046-xTest

8

Nω-Carbamoylation of the Argininamide Moiety: An Avenue to Insurmountable NPY Y1 Receptor Antagonists and a Radiolabeled Selective High-Affinity Molecular Tool ([3H]UR-MK299) with Extended Residence Time

المؤلفون: Max Keller, Burkhard König, Stefanie Dukorn, Günther Bernhardt, Kilian K. Kuhn, Armin Buschauer, Lisa Schindler, Christoph Hutzler, Catherine Mollereau, Stefan Weiss

المصدر: Journal of Medicinal Chemistry. 58:8834-8849

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5e071ac651e06038e58eab66a725d3fTest
https://doi.org/10.1021/acs.jmedchem.5b00925Test

9

cis-1-Oxo-heterocyclyl-4-amido cyclohexane derivatives as NPY5 receptor antagonists

المؤلفون: Noel J. Boyle, Jessie Weiss, Gamini Chandrasena, Lingyun Wu, Andrew D. White, Dario Doller, Michael Sabio, John M. Peterson, Eman Edelmenky, Rajinder Bhardwaj, Xinyan Huang, Chien An Chen, Jiang Yu, Burns James Ford, Bin Chen

المصدر: Bioorganic & Medicinal Chemistry Letters. 24:1458-1461

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f150a8e5e1c03e2d0966895d4d5e9256Test
https://doi.org/10.1016/j.bmcl.2014.02.023Test

10

Heterocyclic modification of a novel bicyclo[3.1.0]hexane NPY1 receptor antagonist

المؤلفون: Shuanghua Hu, Wendy Clarke, Yazhong Huang, John B. Hogan, Lawrence G. Iben, Graham S. Poindexter, Gail K. Mattson, Ling Chen, Guanglin Luo, John W. Russell, Ildiko Antal-Zimanyi

المصدر: Bioorganic & Medicinal Chemistry Letters. 23:3814-3817

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::800f1807028db0439bba719aa1a01b3aTest
https://doi.org/10.1016/j.bmcl.2013.04.095Test

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