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المؤلفون: Anne T. Nies, Elke Schaeffeler, Kathrin Klein, Kathleen M. Giacomini, Michel Eichelbaum, Matthias Schwab, Ute Hofmann, Claudia Neul, Stefan Winter
المصدر: British Journal of Pharmacology. 178:1459-1474
مصطلحات موضوعية: 0301 basic medicine, CYP2D6, SLC47A1, Organic Cation Transport Proteins, Pharmacology, Hydroxylation, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Cations, medicine, Humans, Organic cation transport proteins, biology, Chemistry, Sparteine, Organic Cation Transporter 2, Cytochrome P450, Phenotype, 030104 developmental biology, Cytochrome P-450 CYP2D6, Pharmaceutical Preparations, Debrisoquine, Perhexiline, biology.protein, 030217 neurology & neurosurgery, medicine.drug
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b9d3555d075053f2fad1daf3c8541155Test
https://doi.org/10.1111/bph.15370Test -
2
المؤلفون: Michel Eichelbaum, Claus O. Meese, Thomas Ebner
المصدر: Xenobiotica. 21:847-857
مصطلحات موضوعية: Male, Chromatography, Gas, Magnetic Resonance Spectroscopy, Stereochemistry, Health, Toxicology and Mutagenesis, Metabolite, Sparteine, Administration, Oral, In Vitro Techniques, Toxicology, Biochemistry, Mass Spectrometry, Enamine, chemistry.chemical_compound, Stereospecificity, Cytochrome P-450 Enzyme System, medicine, Animals, Tissue Distribution, Potassium Cyanide, Pharmacology, Quinolizidine, Regioselectivity, Rats, Inbred Strains, Stereoisomerism, General Medicine, Rats, chemistry, Microsomes, Liver, Stereoselectivity, Enantiomer, medicine.drug
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22a1388a3bdab3d69c963244d05bb1fdTest
https://doi.org/10.3109/00498259109039524Test -
3
المؤلفون: Annette S. Gross, Michel Eichelbaum
المصدر: Pharmacology & Therapeutics. 46:377-394
مصطلحات موضوعية: Pharmacology, Polymorphism, Genetic, Sparteine, Metabolism, Biology, Isoquinolines, Isozyme, Debrisoquin, chemistry.chemical_compound, Debrisoquine, chemistry, Plasma concentration, medicine, Animals, Humans, High activity, Pharmacology (medical), Pharmacogenetics, Drug metabolism, medicine.drug
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d20e25c06c8e62186e317d67f22af67Test
https://doi.org/10.1016/0163-7258Test(90)90025-w -
4
المؤلفون: Jürgen Pleiss, Kathrin Klein, Elisabeth Hustert, Tanja Saussele, Ulrich M. Zanger, Stephan Tatzel, Michel Eichelbaum, Sebastian Raimundo
المصدر: Drug metabolism and disposition: the biological fate of chemicals. 35(8)
مصطلحات موضوعية: Models, Molecular, Heterozygote, Heme binding, Genotype, Sparteine, Pharmaceutical Science, Sequence alignment, Heme, Biology, Arginine, digestive system, Isozyme, Polymorphism, Single Nucleotide, chemistry.chemical_compound, Cytochrome P-450 Enzyme System, Gene Frequency, Propafenone, Consensus Sequence, Humans, Amino Acid Sequence, Chromatography, High Pressure Liquid, Pharmacology, Genetics, chemistry.chemical_classification, Binding Sites, Sequence Homology, Amino Acid, Cytochrome P450, Recombinant Proteins, Amino acid, Enzyme, chemistry, Biochemistry, Cytochrome P-450 CYP2D6, biology.protein, Cysteine, Protein Binding
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::84f955e93fcefc50d6fdcab3eac6e2dcTest
https://pubmed.ncbi.nlm.nih.gov/17460029Test -
5
المؤلفون: Christian Funck-Brentano, Catherine Michel, Evelyne Jacqz-Aigrain, Michel Eichelbaum, Ute Hofmann, Jean-Philippe Kévorkian, Heyo K. Kroemer, Marie-Noëlle Peraldi, Patrice Jaillon
المصدر: Clinical pharmacology and therapeutics. 59(5)
مصطلحات موضوعية: Adult, Male, medicine.medical_specialty, Urinary system, Sparteine, Renal function, Administration, Oral, Urine, Gastroenterology, Dextromethorphan, Mixed Function Oxygenases, Pharmacokinetics, Cytochrome P-450 Enzyme System, Oral administration, Dextrorphan, Internal medicine, Oxytocics, medicine, Humans, Pharmacology (medical), Pharmacology, Dose-Response Relationship, Drug, Chemistry, Middle Aged, Antitussive Agents, Endocrinology, Phenotype, Cytochrome P-450 CYP2D6, Creatinine, Kidney Failure, Chronic, Regression Analysis, Female, medicine.drug
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3abe2d7c5b3d2199aa17162b54fd5e69Test
https://pubmed.ncbi.nlm.nih.gov/8646830Test -
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المؤلفون: Ernst-Ulrich Griese, Adelheid Forster, Klaus Mörike, Dieter Schrenk, Karl Walter Bock, Dierk Brockmeier, Michel Eichelbaum
المصدر: Pharmacogenetics. 4(4)
مصطلحات موضوعية: Adult, Male, CYP2D6, Adolescent, Genotype, Sparteine, Glucuronidation, Physiology, Glucuronates, Pharmacology, Isozyme, Coffee, Mixed Function Oxygenases, chemistry.chemical_compound, Random Allocation, Sex Factors, Cytochrome P-450 Enzyme System, Cytochrome P-450 CYP1A2, Caffeine, Tobacco, Genetics, Medicine, Humans, General Pharmacology, Toxicology and Pharmaceutics, Glucuronosyltransferase, Genotyping, Acetaminophen, business.industry, Smoking, CYP1A2, Middle Aged, Plants, Toxic, Phenotype, chemistry, Cytochrome P-450 CYP2D6, Female, business, Oxidoreductases, Oxidation-Reduction, medicine.drug
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::652fd18791dd21e2bd2803d197c6e141Test
https://pubmed.ncbi.nlm.nih.gov/7987405Test -
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المؤلفون: C O Meese, Heyo K. Kroemer, S Botsch, Georg Heinkele, Michel Eichelbaum
المصدر: European journal of clinical pharmacology. 46(2)
مصطلحات موضوعية: Male, CYP2D6, Glucuronates, Urine, Propafenone, Pharmacology, digestive system, Mixed Function Oxygenases, Excretion, chemistry.chemical_compound, Cytochrome P-450 Enzyme System, medicine, Humans, Pharmacology (medical), skin and connective tissue diseases, Adverse effect, Aged, Sparteine, General Medicine, Middle Aged, Phenotype, Debrisoquine, chemistry, Cytochrome P-450 CYP2D6, Female, medicine.drug
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1302b0554538c2370f23554fd2fbef8Test
https://pubmed.ncbi.nlm.nih.gov/8039531Test -
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المؤلفون: T Ebner, Michel Eichelbaum
المصدر: British journal of clinical pharmacology. 35(4)
مصطلحات موضوعية: Sparteine, Debrisoquin, Pharmacology, Hydroxylation, Mixed Function Oxygenases, chemistry.chemical_compound, Cytochrome P-450 Enzyme System, Propafenone, medicine, Humans, Pharmacology (medical), Polymorphism, Genetic, biology, Aprindine, Cytochrome P450, Quinidine, Kinetics, chemistry, Debrisoquine, Cytochrome P-450 CYP2D6, biology.protein, Microsome, Microsomes, Liver, medicine.drug, Research Article
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bef6c178128570c7fa87da7f227f60ceTest
https://pubmed.ncbi.nlm.nih.gov/8485023Test -
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المؤلفون: Christine Fischer, Gerd Mikus, Annette S. Gross, Michel Eichelbaum
المصدر: Europe PubMed Central
مصطلحات موضوعية: Adult, Male, Sparteine, Urination, Pharmacology, chemistry.chemical_compound, Pharmacokinetics, Oral administration, medicine, Humans, Pharmacology (medical), Flecainide, Analysis of Variance, Polymorphism, Genetic, Chemistry, Stereoisomerism, General Medicine, Hydrogen-Ion Concentration, Debrisoquin, Debrisoquine, Dealkylation, Stereoselectivity, Female, Urine flow, medicine.drug, Clearance, Half-Life, Protein Binding
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56506dc4b8df48b939150037ca99b922Test
https://pubmed.ncbi.nlm.nih.gov/1906003Test -
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المؤلفون: T. Ebner, P. Fischer, C. O. Meese, Michel Eichelbaum
المصدر: European Journal of Pharmacology. 183:1640
مصطلحات موضوعية: Pharmacology, High resolution nmr, Computational chemistry, Stable isotope ratio, Chemistry, Sparteine, medicine, Analytical chemistry, Metabolism, medicine.drug
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::1547df8020c626a726b45d60c8c0b2daTest
https://doi.org/10.1016/0014-2999Test(90)91929-6