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المصدر: PLoS ONE, Vol 16, Iss 3, p e0243645 (2021)
PLoS ONEمصطلحات موضوعية: 0301 basic medicine, Patch-Clamp Techniques, Physiology, Action Potentials, Biochemistry, Ion Channels, 0302 clinical medicine, Calcium Channels, N-Type, Automated patch clamp, Transient Transfection Assay, Cricetinae, Medicine and Health Sciences, Membrane Electrophysiology, Analgesics, Multidisciplinary, Chemistry, Physics, NAV1.7 Voltage-Gated Sodium Channel, Transfection, Electrophysiology, Bioassays and Physiological Analysis, Physical Sciences, 293T cells, Cell lines, Medicine, Biological cultures, Research Article, Science, Biophysics, Neurophysiology, Pain, CHO Cells, Research and Analysis Methods, Calcium Phosphate Transfection, 03 medical and health sciences, Signs and Symptoms, Cricetulus, FuGENE, Animals, Humans, Patch clamp, Molecular Biology Techniques, Molecular Biology, Ion channel, Voltage-gated ion channel, Sodium channel, Electrophysiological Techniques, Biology and Life Sciences, Proteins, High-Throughput Screening Assays, 030104 developmental biology, HEK293 Cells, Microscopy, Fluorescence, Lipofectamine, Calcium Channels, Clinical Medicine, Patch Clamp Techniques, 030217 neurology & neurosurgery, Neuroscience
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b541cc5ff952fab70a9d767a58884ec2Test
https://doaj.org/article/f089b070a4b446cb8df4ca680b12c11cTest -
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المؤلفون: Andrea Sinz, Nina Braun, Stephan A. Pless, Christian Ihling, Søren Friis, Jacob Andersen
المصدر: Braun, N, Friis, S, Ihling, C, Sinz, A, Andersen, J & Pless, S A 2021, ' High-throughput characterization of photocrosslinker-bearing ion channel variants to map residues critical for function and pharmacology ', PLOS Biology, vol. 19, no. 9, e3001321 . https://doi.org/10.1371/journal.pbio.3001321Test
PLoS Biology, Vol 19, Iss 9, p e3001321 (2021)
PLoS Biologyمصطلحات موضوعية: Atmospheric Science, Physiology, Spider Venoms, Biochemistry, Physical Chemistry, Ion Channels, Spectrum Analysis Techniques, Automated patch clamp, Animal Cells, Medicine and Health Sciences, Cross-Linking, Amino Acids, Biology (General), Receptor, Membrane Electrophysiology, Throughput (business), chemistry.chemical_classification, Fluorescence-Activated Cell Sorting, Chemistry, Physics, General Neuroscience, Methods and Resources, Transfection, Characterization (materials science), Amino acid, Electrophysiology, Bioassays and Physiological Analysis, Spectrophotometry, Physical Sciences, Cytophotometry, Cellular Types, Protons, General Agricultural and Biological Sciences, QH301-705.5, Immune Cells, Immunology, Biophysics, Antigen-Presenting Cells, Neurophysiology, Computational biology, Biology, Research and Analysis Methods, General Biochemistry, Genetics and Molecular Biology, Humans, Environmental Chemistry, Patch clamp, Molecular Biology Techniques, Molecular Biology, Ion channel, Nuclear Physics, Nucleons, Chemical Bonding, General Immunology and Microbiology, Ecology and Environmental Sciences, Electrophysiological Techniques, Biology and Life Sciences, Proteins, Cell Biology, Acid Sensing Ion Channels, HEK293 Cells, Atmospheric Chemistry, Earth Sciences, Peptides, Acid Deposition, Patch Clamp Techniques, Function (biology), Neuroscience
وصف الملف: application/pdf
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c47ac6c5162cc821f06ca74915038c50Test
https://doi.org/10.1101/2020.11.24.392498Test -
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المؤلفون: Abby Sewell, Glenn E. Kirsch, Caiyun Wu, Arianne L. Motter, Fedorov Nikolai, Yuri A. Kuryshev, Lucas C. Armstrong, Michael S. Orr, Zhiqi Liu, Carmine Leggett
المصدر: Slas Discovery
مصطلحات موضوعية: 0301 basic medicine, Agonist, Patch-Clamp Techniques, medicine.drug_class, Genetic Vectors, Gene Expression, Receptors, Nicotinic, Pharmacology, Nucleus accumbens, Transfection, Biochemistry, Cell Line, Analytical Chemistry, Small Molecule Libraries, Nicotine, 03 medical and health sciences, 0302 clinical medicine, Automated patch clamp, Drug Discovery, medicine, Humans, Patch clamp, nicotinic acetylcholine receptor, Cloning, Molecular, Original Research, Acetylcholine receptor, Chemistry, Electrophysiological Phenomena, High-Throughput Screening Assays, Protein Subunits, Nicotinic acetylcholine receptor, 030104 developmental biology, Nicotinic agonist, ion channel, electrophysiological screening, Molecular Medicine, automated patch clamp, Ion Channel Gating, 030217 neurology & neurosurgery, Biotechnology, medicine.drug
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc1e31ebce6f9b777c6201a00c062cd3Test
https://doi.org/10.1177/2472555217696794Test -
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المصدر: Simo Vicens, R, Sauter, D R P, Grunnet, M, Diness, J G & Bentzen, B H 2017, ' Effect of antiarrhythmic drugs on small conductance calcium –activated potassium channels ', European Journal of Pharmacology, vol. 803, pp. 118-123 . https://doi.org/10.1016/j.ejphar.2017.03.039Test
European Journal of Pharmacologyمصطلحات موضوعية: Faculty of Health and Medical Sciences, 0301 basic medicine, Small-Conductance Calcium-Activated Potassium Channels, antiarrhythmic drug, Dofetilide, Propafenone, 030204 cardiovascular system & hematology, Pharmacology, SK channel, 03 medical and health sciences, 0302 clinical medicine, kca2 channel, calcium-activated potassium channel, Atrial Fibrillation, medicine, Humans, Sinus rhythm, Patch clamp, Chemistry, Atrial fibrillation, Cardiac action potential, medicine.disease, Calcium-activated potassium channel, 3. Good health, HEK293 Cells, 030104 developmental biology, automated patch clamp, Anti-Arrhythmia Agents, medicine.drug
وصف الملف: application/pdf
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8f591c9b789054b93669329815b683aTest
https://doi.org/10.1016/j.ejphar.2017.03.039Test -
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المؤلفون: Takayuki Oka, Alison Obergrussberger, Søren Friis, Hatsue Furukawa, Nina Brinkwirth, Sonja Stoelzle-Feix, Atsushi Ohtsuki, Yuka Hasegawa, Kiyoshi Takasuna, Niels Fertig, Masafumi Doi, Nadine Becker
المصدر: Journal of Pharmacological and Toxicological Methods. 105:106884
مصطلحات موضوعية: ERG1 Potassium Channel, Patch-Clamp Techniques, hERG, Drug Evaluation, Preclinical, Dofetilide, CHO Cells, 030204 cardiovascular system & hematology, Polypropylenes, Toxicology, 030226 pharmacology & pharmacy, Cell Line, 03 medical and health sciences, Cricetulus, 0302 clinical medicine, Automated patch clamp, Drug Discovery, Phenethylamines, medicine, Animals, Humans, Patch clamp, Polytetrafluoroethylene, Ion channel, Pharmacology, Sulfonamides, biology, Chemistry, Drug discovery, Safety pharmacology, Reproducibility of Results, Arrhythmias, Cardiac, Cardiovascular Agents, Heart, Astemizole, Reference Standards, Benchmarking, HEK293 Cells, Calibration, biology.protein, Terfenadine, medicine.drug, Biomedical engineering
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a232b0cdc1e86e3a7f7560e3afb49141Test
https://doi.org/10.1016/j.vascn.2020.106884Test -
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المؤلفون: Fajun Nan, Zhaobing Gao, Jinfeng Yue, Guan-hua Qiao, Ni Liu
المصدر: Acta Pharmacologica Sinica. 37:105-110
مصطلحات موضوعية: 0301 basic medicine, Screening techniques, Patch-Clamp Techniques, High-throughput screening, chemistry.chemical_element, CHO Cells, Fluorescence, 03 medical and health sciences, Cricetulus, Automated patch clamp, High-Throughput Screening Assays, Barracuda, Animals, KCNQ2 Potassium Channel, Pharmacology (medical), Patch clamp, Thallium, Pharmacology, Chromatography, Traditional medicine, biology, General Medicine, biology.organism_classification, 030104 developmental biology, chemistry, Original Article, Ion Channel Gating, Databases, Chemical
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6aaba1297759526557a8c8e15b3c9f1Test
https://doi.org/10.1038/aps.2015.142Test -
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المؤلفون: Sonja Stölzle-Feix, Nadine Becker, Alison Obergrussberger, Andrea Brüggemann, Clemens Möller, Niels Fertig
المصدر: Channels
مصطلحات موضوعية: Patch-Clamp Techniques, Biophysics, Quantitative Structure-Activity Relationship, Nanotechnology, cardiomyocytes, Review, Biochemistry, Ion, Cell membrane, Small Molecule Libraries, action potential, Automated patch clamp, safety pharmacology, Drug Discovery, medicine, Potassium Channel Blockers, Animals, Humans, Patch clamp, Integral membrane protein, Ion channel, Chemistry, screening, ion channels, temperature, High-Throughput Screening Assays, Electrophysiology, medicine.anatomical_structure, impedance, Flux (metabolism), Sodium Channel Blockers
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f2d55d35260852adabdde2d95a3d964Test
http://europepmc.org/articles/PMC4850050Test -
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المؤلفون: Donglin Guo, Stephen Jenkinson
المصدر: Journal of Pharmacological and Toxicological Methods. 99:106575
مصطلحات موضوعية: Pharmacology, biology, Chemistry, Sodium channel, Wild type, Depolarization, 030204 cardiovascular system & hematology, Nav1.5, Toxicology, 030226 pharmacology & pharmacy, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Minimal effect, Automated patch clamp, Biophysics, biology.protein, Patch clamp, Veratridine
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f202c73bdde80cf5c6a719cb45d7ac64Test
https://doi.org/10.1016/j.vascn.2019.04.001Test -
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المؤلفون: Hervør Lykke Olsen, Jan Gimsa, Denise Franz, Oliver Klink
المصدر: Scientific Data
مصطلحات موضوعية: 0301 basic medicine, Statistics and Probability, Data Descriptor, Patch-Clamp Techniques, Potassium Channels, Cellular differentiation, Library and Information Sciences, Ion channels in the nervous system, Ion Channels, Education, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Automated patch clamp, Humans, Patch clamp, Induced pluripotent stem cell, Ion channel, Ion transport, Tetraethylammonium, Chemistry, Dopaminergic Neurons, Cell Differentiation, Anatomy, Computer Science Applications, Electrophysiology, Induced pluripotent stem cells, 030104 developmental biology, Biophysics, Tetrodotoxin, Statistics, Probability and Uncertainty, 030217 neurology & neurosurgery, Information Systems
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05921c116c3cce654f2d410a76e5ccfdTest
https://pubmed.ncbi.nlm.nih.gov/28440808Test -
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المؤلفون: WeaverC. David, J KadakiaRishin, L OlsenMichelle, BanerjeeSreedatta, S SmithStephen, S DentonJerod, RaphemotRene, DaysEmily
المصدر: ASSAY and Drug Development Technologies. 11:532-543
مصطلحات موضوعية: Patch-Clamp Techniques, Drug Evaluation, Preclinical, Neurotransmission, Pharmacology, Rats, Sprague-Dawley, Automated patch clamp, Drug Discovery, Potassium Channel Blockers, medicine, Animals, Humans, Original ArticlesIon Channel Focus, Patch clamp, Potassium Channels, Inwardly Rectifying, Cells, Cultured, Inward-rectifier potassium ion channel, Chemistry, HEK 293 cells, Potassium channel blocker, Molecular Pharmacology, Flow Cytometry, Small molecule, Rats, HEK293 Cells, Spectrometry, Fluorescence, Astrocytes, Flow Injection Analysis, Biophysics, Molecular Medicine, Ion Channel Gating, medicine.drug
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73bf33c3689dd64a799a53c6caf4b607Test
https://doi.org/10.1089/adt.2013.544Test