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المؤلفون: E. De Vita, Rachael I. Scahill, Filipe B. Rodrigues, R. Tortelli, Mariette Heins, Gunnar Flik, A. J. Lowe, Lauren M. Byrne, Flaviano Giorgini, Eileanoir B. Johnson, Edward J. Wild
المصدر: Journal of Neurochemistry
مصطلحات موضوعية: Adult, Male, 0301 basic medicine, Kynurenine pathway, Pharmacology, Biochemistry, cerebrospinal fluid, Cohort Studies, Pathogenesis, 03 medical and health sciences, Cellular and Molecular Neuroscience, chemistry.chemical_compound, 0302 clinical medicine, Kynurenic acid, Cerebrospinal fluid, Huntington's disease, blood, medicine, Humans, Prospective Studies, Kynurenine, Chromatography, High Pressure Liquid, Aged, business.industry, Clinical Studies, Biomakers & Imaging, biomarkers, Human brain, Middle Aged, medicine.disease, Magnetic Resonance Imaging, Huntington Disease, Phenotype, 030104 developmental biology, medicine.anatomical_structure, chemistry, Original Article, Female, ORIGINAL ARTICLES, business, 030217 neurology & neurosurgery, Signal Transduction, Quinolinic acid
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6eaf51725f7f138eabd61f8be52c8ce9Test
https://doi.org/10.1111/jnc.15360Test -
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المؤلفون: Odeta Bondarevaite, Flaviano Giorgini, Marta Leite, Sara Adams, Tiago F. Outeiro, Johannes Attems, David J. Koss
المصدر: Brain Pathology
مصطلحات موضوعية: Lewy Body Disease, Male, 0301 basic medicine, Pathology, medicine.medical_specialty, Parkinson's disease, Plaque, Amyloid, Biology, Pathology and Forensic Medicine, Pathogenesis, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, medicine, Humans, Research Articles, Aged, Aged, 80 and over, Alpha-synuclein, Temporal cortex, Amyloid beta-Peptides, proteostasis, Lewy body, alpha‐Synuclein, Dementia with Lewy bodies, RAB39B, General Neuroscience, Neurodegeneration, Brain, Human brain, Middle Aged, medicine.disease, 030104 developmental biology, medicine.anatomical_structure, chemistry, rab GTP-Binding Proteins, Parkinson’s disease, Female, Lewy Bodies, Neurology (clinical), Lewy body dementia, 030217 neurology & neurosurgery, Research Article
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a6f721b5e83361fcaa5b2abc95630f1Test
https://doi.org/10.1111/bpa.12890Test -
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المصدر: Scientific Reports
Scientific Reports, Vol 11, Iss 1, Pp 1-18 (2021)مصطلحات موضوعية: Male, medicine.medical_specialty, Kynurenine pathway, Science, Neuroimmunology, Neuroprotection, Article, Mice, chemistry.chemical_compound, Kynurenine 3-Monooxygenase, Kynurenic acid, Huntington's disease, Internal medicine, medicine, Animals, Inflammation, Mice, Knockout, Multidisciplinary, business.industry, medicine.disease, Mice, Inbred C57BL, Disease Models, Animal, Huntington Disease, Endocrinology, chemistry, Knockout mouse, Medicine, Cytokines, Diseases of the nervous system, Female, business, Gene Deletion, Kynurenine, Neuroscience
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8fa9f8f3cf2364e41de33a65ab1e61b0Test
http://europepmc.org/articles/PMC7943810Test -
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المؤلفون: Mary E.W. Collier, Shaowei Zhang, Nigel S. Scrutton, Flaviano Giorgini
المصدر: Drug Discovery Today
Collier, M E W, Zhang, S, Scrutton, N & Giorgini, F 2021, ' Inflammation control and improvement of cognitive function in COVID-19 infections: Is there a role for kynurenine 3-monooxygenase inhibition? ', Drug discovery today . https://doi.org/10.1016/j.drudis.2021.02.009Testمصطلحات موضوعية: 0301 basic medicine, Nervous system, Kynurenine pathway, Inflammation, Review, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Immune system, Cognition, Kynurenine 3-Monooxygenase, Drug Discovery, medicine, Animals, Humans, Kynurenine, Pharmacology, Sulfonamides, Post-Green, business.industry, Tryptophan, COVID-19, Metabolic pathway, Thiazoles, 030104 developmental biology, medicine.anatomical_structure, Neuroprotective Agents, chemistry, 030220 oncology & carcinogenesis, Immunology, Respiratory virus, medicine.symptom, business, Signal Transduction
وصف الملف: application/pdf
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e9a6c7e6f3e021b6ffb5f3109bc206aTest
http://europepmc.org/articles/PMC7889466Test -
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المؤلفون: Shaowei Zhang, Robert Schwarcz, Derren J. Heyes, Carlo Breda, Christopher David Edlin, Flaviano Giorgini, Nigel S. Scrutton, Girdhar Singh Deora, Colin Levy, Kevin D. Read, Marina Wright Muelas, Douglas B. Kell, David Leys, Benjamin P. Ross, Philip J. R. Day, Alex D Klausing, Stephen O’Hagan, Michiyo Sakuma
المصدر: Communications Biology, Vol 2, Iss 1, Pp 1-10 (2019)
Zhang, S, Sakuma, M, Deora, G S, Levy, C, Klausing, A, Breda, C, Read, K D, Ross, B P, Wright Muelas, M, Day, P, O'Hagan, S, Kell, D, Schwarcz, R, Leys, D, Heyes, D, Giorgini, F & Scrutton, N 2019, ' A brain-permeable inhibitor of the neurodegenerative disease target kynurenine 3-monooxygenase prevents accumulation of neurotoxic metabolites ', Communications Biology . https://doi.org/10.1038/s42003-019-0520-5Test
Communications Biology
COMMUNICATIONS BIOLOGYمصطلحات موضوعية: Kynurenine pathway, Metabolite, Medicine (miscellaneous), Pharmacology, Neuroprotection, Article, General Biochemistry, Genetics and Molecular Biology, Pathogenesis, Mice, 03 medical and health sciences, chemistry.chemical_compound, Kynurenine 3-Monooxygenase, 0302 clinical medicine, Manchester Institute of Biotechnology, medicine, Animals, Neurodegeneration, Enzyme Inhibitors, lcsh:QH301-705.5, X-ray crystallography, 030304 developmental biology, 0303 health sciences, Drug discovery, business.industry, Brain, Neurodegenerative Diseases, Hydrogen Peroxide, Prodrug, medicine.disease, ResearchInstitutes_Networks_Beacons/manchester_institute_of_biotechnology, Chemical biology, 3. Good health, chemistry, lcsh:Biology (General), Blood-Brain Barrier, General Agricultural and Biological Sciences, business, 030217 neurology & neurosurgery, Kynurenine
وصف الملف: application/pdf
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8cef15ca27e150c8aaa51693da774887Test
http://link.springer.com/article/10.1038/s42003-019-0520-5Test -
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المؤلفون: Flaviano Giorgini, Tiago F. Outeiro, Susanna Campesan, David J. Koss
المصدر: Movement disorders 36(8), 1744-1758 (2021). doi:10.1002/mds.28605
مصطلحات موضوعية: 0301 basic medicine, Lewy Body Disease, Neurite, Endosome, alpha-synuclein, GTPase, Biology, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, genetics [Lewy Body Disease], genetics [Parkinson Disease], medicine, Humans, endocytosis, ddc:610, metabolism [alpha-Synuclein], Alpha-synuclein, Lewy body, RAB39B, Autophagy, Neurodegeneration, neurodegeneration, Parkinson Disease, Lewy body diseases, medicine.disease, metabolism [Lewy Bodies], metabolism [rab GTP-Binding Proteins], 030104 developmental biology, Neurology, chemistry, rab GTP-Binding Proteins, alpha-Synuclein, genetics [alpha-Synuclein], Lewy Bodies, Neurology (clinical), Rab, genetics [rab GTP-Binding Proteins], Neuroscience, 030217 neurology & neurosurgery
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::174a93c41786ddafd79e4ed29cf4a7d4Test
https://pub.dzne.de/record/155579Test -
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المصدر: Arch Biochem Biophys
Zhang, S, Collier, M E W, Heyes, D, Giorgini, F & Scrutton, N 2020, ' Advantages of brain penetrating inhibitors of kynurenine-3-monooxygenase for treatment of neurodegenerative diseases ', Archives of Biochemistry and Biophysics . https://doi.org/10.1016/j.abb.2020.108702Testمصطلحات موضوعية: 0301 basic medicine, Kynurenine pathway, Drug target, Central nervous system, Biophysics, Pharmacology, Biochemistry, Article, 03 medical and health sciences, chemistry.chemical_compound, Kynurenic acid, Kynurenine 3-Monooxygenase, Manchester Institute of Biotechnology, Drug Discovery, Medicine, Animals, Humans, Enzyme Inhibitors, Molecular Biology, Virtual screening, 030102 biochemistry & molecular biology, business.industry, Brain, Neurodegenerative Diseases, Prodrug, ResearchInstitutes_Networks_Beacons/manchester_institute_of_biotechnology, 030104 developmental biology, medicine.anatomical_structure, chemistry, business, Flux (metabolism)
وصف الملف: application/vnd.openxmlformats-officedocument.wordprocessingml.document
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05b72d92a12458119f461aaecc01033aTest
https://europepmc.org/articles/PMC8111166Test/ -
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المؤلفون: Sara Cimini, Tiziana Borsello, Daniel C. Maddison, Mariaelena Repici, Pedro Garção, Kathryn S. Lilley, Kornelis Straatman, Lia Panman, Flaviano Giorgini, Éva M. Szegö, Tiago F. Outeiro, Bhavini Patel, Mahdieh Hassanjani
المساهمون: Giorgini, Flaviano [0000-0001-7881-9508], Apollo - University of Cambridge Repository
المصدر: Molecular Neurobiology
مصطلحات موضوعية: 0301 basic medicine, DJ-1, N-Methylaspartate, Protein Deglycase DJ-1, Neuroscience (miscellaneous), RNA-binding proteins, RNA-binding protein, Cytoplasmic Granules, Article, Mice, 03 medical and health sciences, Cellular and Molecular Neuroscience, 0302 clinical medicine, Stress granule, Osmotic Pressure, Stress, Physiological, medicine, Animals, Humans, Ribonucleoprotein, Neurons, Messenger RNA, Chemistry, Neurodegeneration, HEK 293 cells, RNA, Parkinson Disease, medicine.disease, Rats, Cell biology, Oxidative Stress, HEK293 Cells, 030104 developmental biology, Ribonucleoproteins, Neurology, Stress granules, Nerve Degeneration, Parkinson’s disease, 030217 neurology & neurosurgery, Protein Binding
وصف الملف: application/pdf
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e9f86dfa3fd6f13ca2f5435e191c646Test
https://doi.org/10.1007/s12035-018-1084-yTest -
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المؤلفون: Flaviano Giorgini, Paul J. Muchowski, Marian A. R. Thomas, Sophie Imbeault, Robert Schwarcz, Xi-Cong Liu, Daniel C. Maddison, Ana Pocivavsek, Mariaelena Repici, Joshua L. Smalley, Sophie Erhardt, Markus K. Larsson
المصدر: Biological Psychiatry. 82:756-765
مصطلحات موضوعية: 0301 basic medicine, Elevated plus maze, medicine.medical_specialty, Dextroamphetamine, Central nervous system, Motor Activity, Kynurenic Acid, Article, Open field, Mice, 03 medical and health sciences, chemistry.chemical_compound, Kynurenine 3-Monooxygenase, 0302 clinical medicine, Kynurenic acid, Cerebellum, Internal medicine, medicine, Animals, Biological Psychiatry, Cerebral Cortex, Mice, Knockout, 030104 developmental biology, Endocrinology, medicine.anatomical_structure, Nicotinic agonist, Psychotic Disorders, chemistry, Knockout mouse, Schizophrenia, Schizophrenic Psychology, Psychology, Neuroscience, 030217 neurology & neurosurgery, Kynurenine
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::907d9f091ca59e1c44786aa315623ac2Test
https://doi.org/10.1016/j.biopsych.2016.12.011Test -
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المؤلفون: Diana G. Ferreira, Wei Xiang, Hugo Vicente Miranda, Nuno C. Santos, Luís M. A. Oliveira, Irina Zamolo, Deborah Penque, Olaf Riess, Ruth Rott, Flaviano Giorgini, Carlos Cordeiro, Márcia Oliveira, Marcos António Gomes, Ekrem Darendelioglu, Luísa V. Lopes, Tiago F. Outeiro, Carlo Breda, Alexandre Quintas, Eva F. Rodrigues, Éva M. Szegő, Markus Zweckstetter, Hilal A. Lashuel, Michael Heinrich, Tânia Simões, Rita Oliveira, Ivo C. Martins, Thomas M. Jovin, Francisco J. Enguita, Jochen Klucken, Francesca Munari, Simone Engelender, Ana Ponces-Freire
المصدر: Brain. 144:e58-e58
مصطلحات موضوعية: Synucleinopathies, Glycation, Chemistry, Neurodegeneration, medicine, Cancer research, α synuclein, Neurology (clinical), medicine.disease
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::5d077490bfec4c3dbccdabf2eec5c446Test
https://doi.org/10.1093/brain/awab175Test