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1
المؤلفون: Anna Sieben, F. Thomas Wunderlich, Dong Kong, Xing Xiao, Peter Kloppenburg, André Kleinridders, Thomas E. Scammell, Gagik Yeghiazaryan, Simon Hess, A. Christine Hausen, Paul Klemm, Bradford B. Lowell, Jens C. Brüning, Kamal Rahmouni, Donald A. Morgan
المصدر: Nature Communications, Vol 12, Iss 1, Pp 1-20 (2021)
Nature Communicationsمصطلحات موضوعية: Blood Glucose, medicine.medical_specialty, Median raphe nucleus, Lateral hypothalamus, Science, General Physics and Astronomy, Diet, High-Fat, Serotonergic, Neural circuits, General Biochemistry, Genetics and Molecular Biology, Article, Mice, Nerve Fibers, Dorsal raphe nucleus, Adipose Tissue, Brown, Orexin Receptors, Internal medicine, mental disorders, medicine, Animals, Homeostasis, Glucose homeostasis, Humans, Obesity, Serotonin Plasma Membrane Transport Proteins, Orexins, Multidisciplinary, Raphe, Chemistry, Diabetes, digestive, oral, and skin physiology, General Chemistry, Orexin receptor, Orexin, Glucose, Endocrinology, Liver, nervous system, Hypothalamic Area, Lateral, Raphe Nuclei, Insulin Resistance, Fat metabolism, hormones, hormone substitutes, and hormone antagonists, psychological phenomena and processes, Serotonergic Neurons, Signal Transduction
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39018121014cacedc640165017f559f8Test
https://doaj.org/article/526ad1da292b4e9a9a66f3e0635380a6Test -
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المؤلفون: Clemens Muehlan, Urs Duthaler, Stephane Delahaye, Jasper Dingemanse, Benjamin Berger, Stephan Krähenbühl, Giancarlo Sabattini
المصدر: Clinical Pharmacokinetics. 60:1349-1360
مصطلحات موضوعية: Liver Cirrhosis, medicine.medical_specialty, Pyrrolidines, Cirrhosis, Metabolite, 030226 pharmacology & pharmacy, Gastroenterology, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Pharmacokinetics, Internal medicine, medicine, Humans, Pharmacology (medical), Adverse effect, Pharmacology, Volume of distribution, business.industry, Liver Diseases, Imidazoles, Antagonist, medicine.disease, Orexin receptor, chemistry, Tolerability, Area Under Curve, Orexin Receptor Antagonists, business, 030217 neurology & neurosurgery
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3436174cb8e7e7c5ce550a461a31e69Test
https://doi.org/10.1007/s40262-021-01028-8Test -
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المؤلفون: Corey Strickland, Christina Minnick, Michael J. Breslin, Srivanya Tummala, Kaspar Hollenstein, Alexei Brooun, Vanessa L. Rada, Shawn J. Stachel, Beata Zamlynny, Kira A. Armacost, Dawn L. Hall, Li Xiao, Terrence P. McDonald, Chuan Hong, Kern Jeffrey, Scott A. Hollingsworth, Stephen M. Soisson, Julie A. O'Brien, Andrea T. Partridge, Jennifer M. Shipman, Michael T. Rudd, Noel Byrne
المصدر: Nature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
Nature Communicationsمصطلحات موضوعية: Agonist, Protein Conformation, alpha-Helical, medicine.drug_class, Science, Genetic Vectors, General Physics and Astronomy, Aminopyridines, Gene Expression, Peptide, Plasma protein binding, Pharmacology, Molecular Dynamics Simulation, General Biochemistry, Genetics and Molecular Biology, Article, G protein-coupled receptors, Cryoelectron microscopy, Orexin Receptors, medicine, Escherichia coli, Humans, Protein Interaction Domains and Motifs, Cloning, Molecular, chemistry.chemical_classification, Sulfonamides, Multidisciplinary, Binding Sites, Chemistry, HEK 293 cells, digestive, oral, and skin physiology, General Chemistry, Azepines, Triazoles, medicine.disease, Small molecule, Orexin receptor, Recombinant Proteins, Orexin, HEK293 Cells, Sleep Aids, Pharmaceutical, Orexin Receptor Antagonists, Protein Conformation, beta-Strand, Peptides, Narcolepsy, Protein Binding
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e52de5a726dc2d15e8ae787fb1b0817Test
https://doaj.org/article/71020c0fdeec442e80fbd53a66967a19Test -
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المصدر: Neurology. 98:e493-e505
مصطلحات موضوعية: medicine.medical_specialty, Sarcosine, Metabolite, Population, Body Mass Index, Serine, chemistry.chemical_compound, Internal medicine, medicine, Humans, Metabolomics, education, Narcolepsy, Slow-wave sleep, education.field_of_study, business.industry, Sleep Latency, medicine.disease, Orexin, Endocrinology, chemistry, Metabolome, Neurology (clinical), Serotonin, business
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e423b3ca45fefa7c48d5e94bed837572Test
https://doi.org/10.1212/wnl.0000000000013128Test -
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المؤلفون: Yukiko Ishikawa, Yoko Irukayama-Tomobe, Tsubasa Hino, Naoshi Yamamoto, Hiroshi Nagase, Yasuyuki Nagumo, Masashi Yanagisawa, Noriki Kutsumura, Tsuyoshi Saitoh, Ryuji Tanimura
المصدر: Bioorganicmedicinal chemistry letters. 59
مصطلحات موضوعية: Agonist, Stereochemistry, medicine.drug_class, Clinical Biochemistry, Pharmaceutical Science, Naphthalenes, Ring (chemistry), Biochemistry, chemistry.chemical_compound, Structure-Activity Relationship, Orexin Receptors, Amide, Drug Discovery, medicine, Humans, Molecular Biology, Naphthalene, Aniline Compounds, Dose-Response Relationship, Drug, Molecular Structure, Organic Chemistry, Orexin receptor, chemistry, Docking (molecular), Drug Design, Benzamides, Molecular Medicine, Pharmacophore, Methyl group
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a156a52c16b33607fe4372900cffff08Test
https://pubmed.ncbi.nlm.nih.gov/35007725Test -
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المؤلفون: Junji Furukawa, Chika Higashi, Shunsuke Maehara, Takashi Takeuchi, Takumi Ota, Natsuko Yuge
المصدر: Neuropsychopharmacology Reports
مصطلحات موضوعية: Male, Agonist, medicine.drug_class, Administration, Oral, CHO Cells, Pharmacology, OX1 receptor, Rats, Sprague-Dawley, Cricetulus, Orexin Receptors, In vivo, Cricetinae, medicine, Animals, Humans, Pharmacology (medical), sleep, Receptor, Orexins, Chemistry, Antagonist, Electroencephalography, Original Articles, OX2 receptor, Receptor antagonist, In vitro, Rats, Bioavailability, Orexin, Psychiatry and Mental health, Clinical Psychology, orexin, Original Article, Orexin Receptor Antagonists
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::feb587ea061a73b9b03f49de9c18959cTest
https://doi.org/10.1002/npr2.12105Test -
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المؤلفون: Anne-Laure Morel, Silvia Melzi, Roland S. Liblau, Céline Scoté-Blachon, Yves Dauvilliers, Christelle Peyron
المساهمون: Centre de recherche en neurosciences de Lyon (CRNL), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Université Jean Monnet [Saint-Étienne] (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Institut Toulousain des Maladies Infectieuses et Inflammatoires (Infinity), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Institut des Neurosciences de Montpellier - Déficits sensoriels et moteurs (INM), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM), CHU Montpellier, Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Peyron, Christelle, APPEL À PROJETS GÉNÉRIQUE 2018 - Physiopathologie de la narcolepsie de type 1 - - NARCO-T12018 - ANR-18-CE17-0014 - AAPG2018 - VALID, Centre de recherche en neurosciences de Lyon - Lyon Neuroscience Research Center (CRNL), Université de Lyon-Université de Lyon-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Institut des Neurosciences de Montpellier (INM), ANR-18-CE17-0014,NARCO-T1,Physiopathologie de la narcolepsie de type 1(2018)
المصدر: Brain Pathology
Brain Pathology, Wiley, 2021, ⟨10.1111/bpa.13027⟩
Brain Pathology, 2022, 32 (2), pp.e13027. ⟨10.1111/bpa.13027⟩مصطلحات موضوعية: MESH: Histamine* / metabolism, [SDV]Life Sciences [q-bio], MESH: Histidine Decarboxylase / genetics, Histidine Decarboxylase, Mixed Function Oxygenases, Mice, chemistry.chemical_compound, MESH: Narcolepsy* / genetics, 0302 clinical medicine, MESH: Orexins / metabolism, MESH: Animals, hypothalamus, 0303 health sciences, Microglia, General Neuroscience, MESH: Mixed Function Oxygenases, [SDV] Life Sciences [q-bio], medicine.anatomical_structure, Hypothalamus, [SDV.IMM]Life Sciences [q-bio]/Immunology, Histamine, medicine.medical_specialty, [SDV.IMM] Life Sciences [q-bio]/Immunology, Biology, Pathology and Forensic Medicine, 03 medical and health sciences, Internal medicine, medicine, Animals, Humans, RNA, Messenger, sleep, MESH: Mice, Neuroinflammation, MESH: RNA, Messenger, Narcolepsy, 030304 developmental biology, MESH: Narcolepsy* / metabolism, Orexins, MESH: Humans, Histaminergic, medicine.disease, Pons, Orexin, Endocrinology, orexin, nervous system, chemistry, Neurology (clinical), hypocretin, 030217 neurology & neurosurgery
وصف الملف: application/pdf
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4490e3482708d0b4df213bb72bef01faTest
https://doi.org/10.1111/bpa.13027Test -
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المؤلفون: Fabio Arturo Iannotti, Fabiana Piscitelli, Pietro Amodeo, Rosa Maria Vitale, Vincenzo Di Marzo, Ranjev Savopoulos, Luigia Cristino, Aniello Schiano Moriello, Royston A. Gray, Luciano De Petrocellis, Lea Tunisi
المصدر: Biomolecules, Vol 11, Iss 1134, p 1134 (2021)
Biomolecules
Volume 11
Issue 8
Biomolecules 11 (2021). doi:10.3390/biom11081134
info:cnr-pdr/source/autori:Vitale R.M.; Iannotti F.A.; Moriello A.S.; Tunisi L.; Piscitelli F.; Savopoulos R.; Cristino L.; De Petrocellis L.; Amodeo P.; Gray R.; Di Marzo V./titolo:Identification and characterization of cannabidiol as an ox1r antagonist by computational and in vitro functional validation/doi:10.3390%2Fbiom11081134/rivista:Biomolecules/anno:2021/pagina_da:/pagina_a:/intervallo_pagine:/volume:11مصطلحات موضوعية: Protein Conformation, alpha-Helical, 0301 basic medicine, Gene Expression, Pharmacology, Biochemistry, Radioligand Assay, cannabidiol, 0302 clinical medicine, Transgenes, Receptor, media_common, Chemistry, calcium mobilization assay, Ligand (biochemistry), calcium influx assay, Orexin receptor, QR1-502, Molecular Imaging, Molecular Docking Simulation, calcium imaging, Anticonvulsants, Orexin Receptor Antagonists, Protein Binding, medicine.drug, Drug, orexin receptors, OX1R, media_common.quotation_subject, CHO Cells, Microbiology, Article, 03 medical and health sciences, Cricetulus, medicine, Animals, Humans, Protein Interaction Domains and Motifs, Molecular Biology, Orexins, Binding Sites, Antagonist, antagonist, molecular docking, In vitro, molecular dynamics, Orexin, Kinetics, 030104 developmental biology, Anti-Anxiety Agents, Calcium, Protein Conformation, beta-Strand, Cannabidiol, 030217 neurology & neurosurgery
وصف الملف: application/pdf
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::774e5847c77075e8bf23ab08f2e5ffadTest
https://www.mdpi.com/2218-273X/11/8/1134Test -
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المؤلفون: Martine Gehin, Jolanta Wierdak, Jasper Dingemanse, Giancarlo Sabattini, Patricia N. Sidharta
المصدر: British journal of clinical pharmacologyREFERENCES. 88(2)
مصطلحات موضوعية: Male, Efavirenz, Pyrrolidines, Cmax, Pharmacology, chemistry.chemical_compound, Pharmacokinetics, Medicine, Cytochrome P-450 CYP3A, Humans, Pharmacology (medical), Drug Interactions, Prospective Studies, CYP3A4, business.industry, Antagonist, Imidazoles, Cytochrome P-450 CYP3A Inducers, Hydrogen-Ion Concentration, Famotidine, Orexin receptor, Tolerability, chemistry, Area Under Curve, Orexin Receptor Antagonists, business, medicine.drug
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43f316bb390a8f0097914f56d1a5ca2dTest
https://pubmed.ncbi.nlm.nih.gov/34371524Test -
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المؤلفون: Masahiro Tsuboi, Yinghan Su, Jun Suzuki, Toshiaki Yoshikawa, Shota Yamazaki, Ryo Morisue, Atsushi Ochiai, Tetsuya Nakatsura, Genichiro Ishii
المصدر: Pathobiology. 88:218-227
مصطلحات موضوعية: Lung Neoplasms, T cell, Programmed Cell Death 1 Receptor, Pathology and Forensic Medicine, 03 medical and health sciences, Lymphocytes, Tumor-Infiltrating, 0302 clinical medicine, Immune system, Orexin Receptors, Carcinoma, Non-Small-Cell Lung, Biomarkers, Tumor, medicine, Humans, Cytotoxic T cell, CTLA-4 Antigen, Lung cancer, Receptor, Hepatitis A Virus Cellular Receptor 2, Molecular Biology, biology, Chemistry, Cell Biology, General Medicine, medicine.disease, Immune checkpoint, Up-Regulation, medicine.anatomical_structure, CTLA-4, 030220 oncology & carcinogenesis, biology.protein, Cancer research, Antibody, 030215 immunology
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca158040bc5f6ff4ef95602b570bbcddTest
https://doi.org/10.1159/000511557Test