المؤلفون: Rasmus Jorgensen, Luise Gram Schleiss, Kirsten Raun, Jacob Kofoed, Claus Bekker Jeppesen, Birgitte Schjellerup Wulff, Berit Østergaard Christoffersen, Jørgen Olsen, Lars Ynddal, Franziska Zosel, Ulrich Sensfuss, Johan F. Paulsson, Søren Østergaard, Jane Spetzler, Flemming S Nielsen

المصدر: Scientific Reports, Vol 11, Iss 1, Pp 1-15 (2021)
Scientific Reports

مصطلحات موضوعية: Swine, Science, Serum albumin, Peptide, Lipid-anchored protein, Medicinal chemistry, CHO Cells, Biochemistry, Article, Acylation, Lipopeptides, Cricetulus, In vivo, Cricetinae, Potency, Animals, Humans, Peptide YY, Obesity, chemistry.chemical_classification, Pharmacology, Lead optimization, Multidisciplinary, biology, Drug discovery, Fatty Acids, Albumin, Fatty acid, Acetylation, Liraglutide, Receptors, Neuropeptide Y, Drug Combinations, HEK293 Cells, chemistry, Drug delivery, biology.protein, Swine, Miniature, Medicine, Female, Anti-Obesity Agents, Peptides, Oligopeptides, Half-Life, Protein Binding

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b070773ae97f4392dec87755c1751435Test
https://doaj.org/article/cec7ec4e645c44c5a30946919c1e7741Test

المؤلفون: Christian L. Roth, Oleg G. Chepurny, Bart C. De Jonghe, George G. Holz, Clinton Elfers, Kylie S. Chichura, Matthew R. Hayes, Tito Borner, Robert P. Doyle, Ian R. Sweet, Brandon T. Milliken

المصدر: J Med Chem

مصطلحات موضوعية: Blood Glucose, Male, Models, Molecular, Vomiting, Nausea, Neuropeptide, Peptide, Type 2 diabetes, Pharmacology, Binding, Competitive, 01 natural sciences, Article, Glucagon-Like Peptide-1 Receptor, Rats, Sprague-Dawley, Islets of Langerhans, Structure-Activity Relationship, 03 medical and health sciences, Weight loss, In vivo, Insulin Secretion, Weight Loss, Drug Discovery, medicine, Animals, Humans, Peptide YY, Receptor, 030304 developmental biology, chemistry.chemical_classification, 0303 health sciences, Shrews, medicine.disease, In vitro, Rats, Receptors, Neuropeptide Y, 0104 chemical sciences, Molecular Docking Simulation, 010404 medicinal & biomolecular chemistry, Glucose, chemistry, Microsomes, Liver, Exenatide, Molecular Medicine, medicine.symptom

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f87628e79fa1735fd176ff82760e989Test
https://doi.org/10.1021/acs.jmedchem.0c01783Test

المؤلفون: A. Richard Chamberlin, A. John Yucel, Zachary R. Woydziak

المصدر: ChemMedChem

مصطلحات موضوعية: animal structures, Stereochemistry, Phosphatase, macromolecular substances, environment and public health, 01 natural sciences, Biochemistry, Article, Serine, Structure-Activity Relationship, chemistry.chemical_compound, Drug Discovery, Humans, Protein Phosphatase 2, Enzyme Inhibitors, General Pharmacology, Toxicology and Pharmaceutics, Threonine, Furans, IC50, Pharmacology, Dose-Response Relationship, Drug, Molecular Structure, biology, 010405 organic chemistry, Chemistry, Organic Chemistry, Active site, Protein phosphatase 2, Lipids, Receptors, Neuropeptide Y, 0104 chemical sciences, enzymes and coenzymes (carbohydrates), 010404 medicinal & biomolecular chemistry, embryonic structures, biology.protein, Molecular Medicine, Tautomycin, Selectivity

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c41f38ec9e6986e89eb3b1be678f627Test
https://doi.org/10.1002/cmdc.202000801Test

المؤلفون: Annette G. Beck-Sickinger, Paul Hoppenz, Isabelle Ziffert, Anette Kaiser, Karin Mörl

المصدر: Chemmedchem

مصطلحات موضوعية: neuropeptide Y, media_common.quotation_subject, Peptide, cell lines, Ligands, 01 natural sciences, Biochemistry, law.invention, chemistry.chemical_compound, Biosynthesis, law, Very Important Paper, Cell Line, Tumor, Drug Discovery, cancer, Humans, General Pharmacology, Toxicology and Pharmaceutics, Receptor, Internalization, media_common, G protein-coupled receptor, Fluorescent Dyes, Pharmacology, chemistry.chemical_classification, shuttling, Drug Carriers, Arrestin, Microscopy, Confocal, Full Paper, 010405 organic chemistry, Organic Chemistry, Full Papers, Ligand (biochemistry), 0104 chemical sciences, Receptors, Neuropeptide Y, 010404 medicinal & biomolecular chemistry, HEK293 Cells, Targeted drug delivery, chemistry, Pharmaceutical Preparations, drug delivery, Recombinant DNA, Biophysics, Molecular Medicine, Protein Binding

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7eb9bad27c063f76fd618dd2724d7666Test
http://europepmc.org/articles/PMC7818256Test

المؤلفون: Sylvia Els-Heindl, Robert Kuhnert, Johannes Köbberling, Annette G. Beck-Sickinger, Martin Kellert, Stefan Saretz, Evamarie Hey-Hawkins, Dennis J. Worm, Paul Hoppenz, Bernd Riedl

المصدر: Journal of Medicinal Chemistry. 63:2358-2371

مصطلحات موضوعية: Cancer therapy, chemistry.chemical_element, Boron Neutron Capture Therapy, 01 natural sciences, 03 medical and health sciences, Drug Delivery Systems, Neoplasms, Drug Discovery, Humans, Neuropeptide Y, Boranes, Receptor, Boron, 030304 developmental biology, Drug Carriers, 0303 health sciences, Neuropeptide Y receptor, Combinatorial chemistry, Receptors, Neuropeptide Y, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, Neutron capture, HEK293 Cells, chemistry, Cancer cell, MCF-7 Cells, Molecular Medicine, Carborane, Conjugate

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d05201aa491b226500d90a98abd53589Test
https://doi.org/10.1021/acs.jmedchem.9b01136Test

المؤلفون: Dariush Hinderberger, Peter Schmidt, Annette G. Beck-Sickinger, Anette Kaiser, Jeannette M Laugwitz, Haleh H. Haeri, Ulrike Krug

المصدر: Molecules
Molecules, Vol 25, Iss 4143, p 4143 (2020)
Volume 25
Issue 18

مصطلحات موضوعية: Models, Molecular, Protein Conformation, Intracellular Space, Pharmaceutical Science, Gene Expression, IDSL, 01 natural sciences, Analytical Chemistry, law.invention, refolding, chemistry.chemical_compound, GPCR, law, Drug Discovery, Electron paramagnetic resonance, Promoter Regions, Genetic, 0303 health sciences, Chemistry, Transmembrane protein, Chemistry (miscellaneous), ddc:540, Molecular Medicine, MTSL, Transcriptional Activation, Nitroxide mediated radical polymerization, DEER, Article, lcsh:QD241-441, 03 medical and health sciences, Structure-Activity Relationship, lcsh:Organic chemistry, Humans, Amino Acid Sequence, Cysteine, Physical and Theoretical Chemistry, Y2R, EPR, nitroxide spin labels, 030304 developmental biology, G protein-coupled receptor, 010405 organic chemistry, Pulsed EPR, Organic Chemistry, Cell Membrane, Electron Spin Resonance Spectroscopy, Site-directed spin labeling, 0104 chemical sciences, Receptors, Neuropeptide Y, HEK293 Cells, Biophysics, Mutagenesis, Site-Directed, Biomarkers

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6d7351ce04c4c84e9d72d03732bd569Test
http://europepmc.org/articles/PMC7571237Test

المؤلفون: Patrick O. Sakyi, Dorcas Osei-Safo, Ivan Addae-Mensah, Richard Amewu

المصدر: Molecules, Vol 26, Iss 7134, p 7134 (2021)
Molecules

مصطلحات موضوعية: Vascular Endothelial Growth Factor A, Angiogenesis, Pharmaceutical Science, Antineoplastic Agents, Review, multiple biological targets, Fibroblast growth factor, Analytical Chemistry, angiogenesis, chemistry.chemical_compound, QD241-441, vascularization, heterocyclic compounds, Epidermal growth factor, Neoplasms, homeostasis, Drug Discovery, Humans, metastasis, Physical and Theoretical Chemistry, Thymidine phosphorylase, Platelet-Derived Growth Factor, Biological Products, Thymidine Phosphorylase, Natural product, Epidermal Growth Factor, biology, Chemistry, Organic Chemistry, apoptosis, Receptors, Neuropeptide Y, Fibroblast Growth Factors, Vascular endothelial growth factor, Chemistry (miscellaneous), Cancer cell, biology.protein, Cancer research, Molecular Medicine, Platelet-derived growth factor receptor

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e829929adb8cc0d2d025e52c50b40f68Test
https://doi.org/10.3390/molecules26237134Test

المؤلفون: Marleen Groenen, Simon J. Mountford, Mengjie Liu, Philip E. Thompson, Nicholas D. Holliday, Rachel R. Richardson, Stephen J. Briddon

المصدر: Journal of medicinal chemistry. 63(10)

مصطلحات موضوعية: Stereochemistry, Dimer, Peptide, CHO Cells, Peptides, Cyclic, chemistry.chemical_compound, Cricetulus, Cricetinae, Drug Discovery, Animals, Humans, Receptor, chemistry.chemical_classification, biology, Dose-Response Relationship, Drug, Chinese hamster ovary cell, Neuropeptides, Antagonist, biology.organism_classification, Receptors, Neuropeptide Y, Ring size, HEK293 Cells, chemistry, Molecular Medicine, Protein Multimerization, Selectivity

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16598329f448b7f619db754ca8ac4cd0Test
https://pubmed.ncbi.nlm.nih.gov/32364733Test

المؤلفون: Annette G. Beck-Sickinger, Peter Schmidt, Sarah Wistuba, Mathias Bosse, Alexander Vogel, Peter W. Hildebrand, Marcel Gauglitz, Daniel Huster, Vsevolod V. Gurevich, Anette Kaiser

المصدر: Molecules
Molecules, Vol 25, Iss 5489, p 5489 (2020)
Volume 25
Issue 23

مصطلحات موضوعية: Magnetic Resonance Spectroscopy, Protein Conformation, Pharmaceutical Science, Molecular Dynamics Simulation, 010402 general chemistry, Neuropeptide Y Receptor Type 1, 01 natural sciences, Article, Analytical Chemistry, lcsh:QD241-441, 03 medical and health sciences, Molecular dynamics, Structure-Activity Relationship, GPCR, NMR spectroscopy, lcsh:Organic chemistry, Drug Discovery, Physical and Theoretical Chemistry, Lipid bilayer, Nuclear Magnetic Resonance, Biomolecular, 030304 developmental biology, Molecular switch, 0303 health sciences, Chemistry, arrestin, Organic Chemistry, MD simulation, Nuclear magnetic resonance spectroscopy, 500 Naturwissenschaften und Mathematik::570 Biowissenschaften, Biologie::570 Biowissenschaften, Biologie, structural dynamics, Recombinant Proteins, 0104 chemical sciences, Receptors, Neuropeptide Y, molecular switch, Transmembrane domain, Solid-state nuclear magnetic resonance, Chemistry (miscellaneous), Helix, Biophysics, Molecular Medicine

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e4779e26d0088fb0f381f41cefdaab60Test

المؤلفون: Guenther Bernhardt, Peter Schmidt, David Wifling, Bo Xu, Kerstin Burkert, Qiang Zhao, Cuiying Yi, Max Keller, Rongguang Zhang, Raymond C. Stevens, Beibei Li, Daniel Huster, Beili Wu, Timo Littmann, Anette Kaiser, Shuo Han, Lisa Maria Kögler, Mathias Bosse, Armin Buschauer, Sheng Ye, Jens Meiler, Dan Larhammar, Nicole Plank, Zhenlin Yang, Annette G. Beck-Sickinger, Brian J. Bender

المصدر: Nature

مصطلحات موضوعية: 0301 basic medicine, Agonist, Dihydropyridines, medicine.drug_class, Inositol Phosphates, Arginine, Crystallography, X-Ray, Ligands, Article, Substrate Specificity, Structure-Activity Relationship, 03 medical and health sciences, medicine, Humans, Neuropeptide Y, Receptor, Diphenylacetic Acids, Nuclear Magnetic Resonance, Biomolecular, Binding Sites, Multidisciplinary, 030102 biochemistry & molecular biology, Drug discovery, Chemistry, Phenylurea Compounds, Neuropeptide Y receptor, Ligand (biochemistry), Receptors, Neuropeptide Y, 3. Good health, Molecular Docking Simulation, N-terminus, 030104 developmental biology, Biochemistry, Peptide YY, Mutation, Mutant Proteins, Endogenous agonist, Protein Binding

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35c7c85e188410a47148a2b5ceedc71fTest
https://doi.org/10.1038/s41586-018-0046-xTest