دورية أكاديمية
RNA-Cleaving DNAzymes: Old Catalysts with New Tricks for Intracellular and In Vivo Applications
| العنوان: | RNA-Cleaving DNAzymes: Old Catalysts with New Tricks for Intracellular and In Vivo Applications |
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| المؤلفون: | JingJing Zhang |
| المصدر: | Catalysts, Vol 8, Iss 11, p 550 (2018) |
| بيانات النشر: | MDPI AG |
| سنة النشر: | 2018 |
| المجموعة: | Directory of Open Access Journals: DOAJ Articles |
| مصطلحات موضوعية: | RNA-cleaving DNAzymes, structural characterization, intracellular imaging, in vivo, cancer therapy, gene regulation, Chemical technology, TP1-1185, Chemistry, QD1-999 |
| الوصف: | DNAzymes are catalytically active DNA molecules that are normally isolated through in vitro selection methods, among which RNA-cleaving DNAzymes that catalyze the cleavage of a single RNA linkage embedded within a DNA strand are the most studied group of this DNA enzyme family. Recent advances in DNA nanotechnology and engineering have generated many RNA-cleaving DNAzymes with unique recognition and catalytic properties. Over the past decade, numerous RNA-cleaving, DNAzymes-based functional probes have been introduced into many research areas, such as in vitro diagnostics, intracellular imaging, and in vivo therapeutics. This review focus on the fundamental insight into RNA-Cleaving DNAzymes and technical tricks for their intracellular and in vivo applications, highlighting the recent progress in the clinical trial of RNA-Cleaving DNAzymes with selected examples. The challenges and opportunities for the future translation of RNA-cleaving DNAzymes for biomedicine are also discussed. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 2073-4344 |
| العلاقة: | https://www.mdpi.com/2073-4344/8/11/550Test; https://doaj.org/toc/2073-4344Test; https://doaj.org/article/25b0d295712748798601bd6733bf2cf2Test |
| DOI: | 10.3390/catal8110550 |
| الإتاحة: | https://doi.org/10.3390/catal8110550Test https://doaj.org/article/25b0d295712748798601bd6733bf2cf2Test |
| رقم الانضمام: | edsbas.22CCBFF5 |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 20734344 |
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| DOI: | 10.3390/catal8110550 |