التفاصيل البيبلوغرافية
| العنوان: |
ChemiRs: a web application for microRNAs and chemicals |
| المؤلفون: |
Su, Emily Chia-Yu, Chen, Yu-Sing, Tien, Yun-Cheng, Liu, Jeff, Ho, Bing-Ching, Yu, Sung-Liang, Singh, Sher, 何炳慶, 俞松良 |
| المساهمون: |
臺大醫學院-醫學檢驗暨生物技術學系暨研究所, Su, Emily Chia-Yu, Chen, Yu-Sing, Tien, Yun-Cheng, Liu, Jeff, Ho, Bing-Ching, Yu, Sung-Liang, Singh, Sher, 何炳慶, 俞松良 |
| سنة النشر: |
2016 |
| المجموعة: |
National Taiwan University Institutional Repository (NTUR) |
| مصطلحات موضوعية: |
microRNA, Gene ontology, Chemical, Genomics, Disease |
| الوقت: |
152 |
| الوصف: |
Background: MicroRNAs (miRNAs) are about 22 nucleotides, non-coding RNAs that affect various cellular functions, and play a regulatory role in different organisms including human. Until now, more than 2500 mature miRNAs in human have been discovered and registered, but still lack of information or algorithms to reveal the relations among miRNAs, environmental chemicals and human health. Chemicals in environment affect our health and daily life, and some of them can lead to diseases by inferring biological pathways. ;Results: We develop a creditable online web server, ChemiRs, for predicting interactions and relations among miRNAs, chemicals and pathways. The database not only compares gene lists affected by chemicals and miRNAs, but also incorporates curated pathways to identify possible interactions. ;Conclusions: Here, we manually retrieved associations of miRNAs and chemicals from biomedical literature. We developed an online system, ChemiRs, which contains miRNAs, diseases, Medical Subject Heading (MeSH) terms, chemicals, genes, pathways and PubMed IDs. We connected each miRNA to miRBase, and every current gene symbol to HUGO Gene Nomenclature Committee (HGNC) for genome annotation. Human pathway information is also provided from KEGG and REACTOME databases. Information about Gene Ontology (GO) is queried from GO Online SQL Environment (GOOSE). With a user-friendly interface, the web application is easy to use. Multiple query results can be easily integrated and exported as report documents in PDF format. Association analysis of miRNAs and chemicals can help us understand the pathogenesis of chemical components. ChemiRs is freely available for public use at http://omics.biol.ntnu.edu.tw/ChemiRsTest. ; 醫學檢驗暨生物技術學系暨研究所 ; 醫學院 ; 期刊論文 |
| نوع الوثيقة: |
other/unknown material |
| اللغة: |
English |
| العلاقة: |
BMC Bioinformatics, 17; http://ntur.lib.ntu.edu.tw/handle/246246/280942Test |
| DOI: |
10.1186/s12859-016-1002-0 |
| الإتاحة: |
https://doi.org/10.1186/s12859-016-1002-0Test
http://ntur.lib.ntu.edu.tw/handle/246246/280942Test |
| رقم الانضمام: |
edsbas.273FA167 |
| قاعدة البيانات: |
BASE |
