Association of maternal prenatal smoking GFI1-locus and cardio-metabolic phenotypes in 18,212 adults
| العنوان: | Association of maternal prenatal smoking GFI1-locus and cardio-metabolic phenotypes in 18,212 adults |
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| المؤلفون: | Petri Wiklund, Melanie Waldenberger, Lili Milani, Wei Chen, André G. Uitterlinden, Hans J. Grabe, Pim van der Harst, Shengxu Li, Pashupati P. Mishra, John C. Chambers, Rae-Chi Huang, Jaspal S. Kooner, Giovanni Cugliari, Lawrence J. Beilin, Joyce B. J. van Meurs, Mika Kähönen, Rory P. Wilson, Phillip E. Melton, P. Eline Slagboom, Benjamin Lehne, Matthias Nauck, Simonetta Guarrera, Sylvain Sebert, Giuseppe Matullo, Matthias Wielscher, Weihua Zhang, Tao Zhang, Yan Zhang, Mikko Hurme, Niek de Klein, Hermann Brenner, Marjo-Riitta Järvelin, Krista Fischer, Annette Peters, Silva Kasela, Trevor A. Mori, Taulant Muka, Terho Lehtimäki, Oscar H. Franco, Leonard H. van den Berg, Pooja R. Mandaviya, Toby Andrew, Matthew Suderman, Marie Loh, Niek Verweij, Lude Franke, Ville Karhunen, Priyanka Parmar, Wolfgang Rathmann, Alexander Teumer, Jana Nano, Sonja Kunze, Estelle Lowry, Denise Anderson, Christian Gieger, Philippe Froguel, Dorret I. Boomsma, Jan H. Veldink, Marleen M.J. van Greevenbroek, Caroline L Relton, Salvatore Panico, Bastiaan T. Heijmans, Amélie Bonnefond, Stephan B. Felix, Olli T. Raitakari, Ben Schöttker |
| المساهمون: | Maastricht Centre for Systems Biology, Interne Geneeskunde, RS: CARIM - R3.01 - Vascular complications of diabetes and the metabolic syndrome, RS: FSE MaCSBio, Internal Medicine, Epidemiology, Lee Kong Chian School of Medicine (LKCMedicine), Biological Psychology, APH - Mental Health, APH - Methodology, Amsterdam Neuroscience - Mood, Anxiety, Psychosis, Stress & Sleep, Parmar, Priyanka, Lowry, Estelle, Cugliari, Giovanni, Suderman, Matthew, Wilson, Rory, Karhunen, Ville, Andrew, Toby, Wiklund, Petri, Wielscher, Matthia, Guarrera, Simonetta, Teumer, Alexander, Lehne, Benjamin, Milani, Lili, de Klein, Niek, Mishra, Pashupati P, Melton, Phillip E, Mandaviya, Pooja R, Kasela, Silva, Nano, Jana, Zhang, Weihua, Zhang, Yan, Uitterlinden, Andre G, Peters, Annette, Schöttker, Ben, Gieger, Christian, Anderson, Denise, Boomsma, Dorret I, Grabe, Hans J, Panico, Salvatore, Veldink, Jan H, van Meurs, Joyce B J, van den Berg, Leonard, Beilin, Lawrence J, Franke, Lude, Loh, Marie, van Greevenbroek, Marleen M J, Nauck, Matthia, Kähönen, Mika, Hurme, Mikko A, Raitakari, Olli T, Franco, Oscar H, Slagboom, P Eline, van der Harst, Pim, Kunze, Sonja, Schill, FELIX STEPHAN, Zhang, Tao, Chen, Wei, Mori, Trevor A, Bonnefond, Amelie, Heijmans, Bastiaan T, Muka, Taulant, Kooner, Jaspal S, Fischer, Krista, Waldenberger, Melanie, Froguel, Philippe, Huang, Rae-Chi, Lehtimäki, Terho, Rathmann, Wolfgang, Relton, Caroline L, Matullo, Giuseppe, Brenner, Hermann, Verweij, Niek, Li, Shengxu, Chambers, John C, Järvelin, Marjo-Riitta, Sebert, Sylvain, Groningen Institute for Gastro Intestinal Genetics and Immunology (3GI), Cardiovascular Centre (CVC), Stem Cell Aging Leukemia and Lymphoma (SALL) |
| المصدر: | EBioMedicine EBioMedicine, 38, 206-216. Elsevier EBioMedicine, 38, 206-216 Boomsma, D I, for the BIOS Consortium & for the GLOBAL Meth QTL Consortium 2018, ' Association of maternal prenatal smoking GFI1-locus and cardio-metabolic phenotypes in 18,212 adults ', Ebiomedicine, vol. 38, pp. 206-216 . https://doi.org/10.1016/j.ebiom.2018.10.066Test Parmar, P & BIOS Consortium 2018, ' Association of maternal prenatal smoking GFI1-locus and cardio-metabolic phenotypes in 18,212 adults ', EBioMedicine, vol. 38, pp. 206-216 . https://doi.org/10.1016/j.ebiom.2018.10.066Test Parmar, P, Lowry, E, Cugliari, G, Suderman, M, Wilson, R, Karhunen, V, Andrew, T, Wiklund, P, Wielscher, M, Guarrera, S, Teumer, A, Lehne, B, Milani, L, de Klein, N, Mishra, P, Melton, P, Mandaviya, P, Kasela, S, Nano, J, Zhang, W, Zhang, Y, Uitterlinden, A, Peters, A, Schottker, B, Gieger, C, Anderson, D, Boomsma, D, Grabe, H, Panico, S, Veldink, J, van Meurs, J, van den Berg, L, Beilin, L, Franke, L, Loh, M, van Greevenbroek, M, Nauck, M, Kahonen, M, Hurme, M, Raitakari, O, Franco, O, Slagboom, P, van der Harst, P, Kunze, S, Felix, S, Zhang, T, Chen, W, Mori, T, Bonnefond, A, Heijmans, B, Muka, T, Kooner, J, Fischer, K, Waldenberger, M, Froguel, P, Huang, R, Lehtimaki, T, Rathman, W, Relton, C, Matullo, G, Brenner, H, Verweij, N, Li, S, Chambers, J, Jarvelin, M-R & Sebert, S 2018, ' Association of maternal prenatal smoking GFI1-locus and cardio-metabolic phenotypes in 18,212 adults ', EBioMedicine, vol. 38, pp. 206-216 . https://doi.org/10.1016/j.ebiom.2018.10.066Test Ebiomedicine, 38, 206-216. Elsevier BV EBioMedicine 38, 206-216 (2018). doi:10.1016/j.ebiom.2018.10.066 EBioMedicine 38, 206-216 (2018) EBioMedicine, 38, 206-216. ELSEVIER SCIENCE BV |
| مصطلحات موضوعية: | Genetics and Molecular Biology (all), Male, Netherlands Twin Register (NTR), 0301 basic medicine, Research paper, GFI1 protein, human, GFI1-locus, raskaus, Research & Experimental Medicine, cardio-metabolic phenotypes, Biochemistry, Epigenesis, Genetic, GLOBAL Meth QTL Consortium, 0302 clinical medicine, Pregnancy, Smoke, 030212 general & internal medicine, maternal prenatal smoking, DNA METHYLATION, media_common, RISK, 2. Zero hunger, education.field_of_study, Smoking, ta3142, General Medicine, Middle Aged, genetics [Transcription Factors], 3. Good health, DNA-Binding Proteins, Phenotype, Medicine, Research & Experimental, CARDIOVASCULAR-DISEASE, epigenetiikka, Population Surveillance, Prenatal Exposure Delayed Effects, DNA methylation, Female, Disease Susceptibility, BIOS Consortium, Medical Genetics, Life Sciences & Biomedicine, Adult, medicine.medical_specialty, Offspring, Birth weight, Population, Mothers, genetics [DNA-Binding Proteins], ta3111, Methylation, General Biochemistry, Genetics and Molecular Biology, DIET, 03 medical and health sciences, Medicine, General & Internal, SDG 3 - Good Health and Well-being, tupakointi, General & Internal Medicine, Internal medicine, medicine, media_common.cataloged_instance, Humans, ddc:610, adverse effects [Maternal Exposure], EXPOSURE, Epigenetics, European union, education, Medicinsk genetik, EPIGENOME-WIDE ASSOCIATION, Biochemistry, Genetics and Molecular Biology (all), Science & Technology, business.industry, adverse effects [Smoking], DNA Methylation, ta3121, medicine.disease, BIRTH-WEIGHT, 030104 developmental biology, Endocrinology, Genetic Loci, sydän- ja verisuonitaudit, CpG Islands, CIGARETTE-SMOKING, CESSATION, Energy Metabolism, metabolism [Myocardium], business, Body mass index, Biomarkers, Transcription Factors |
| الوصف: | Background: DNA methylation at the GFI1-locus has been repeatedly associated with exposure to smoking from the foetal period onwards. We explored whether DNA methylation may be a mechanism that links exposure to maternal prenatal smoking with offspring's adult cardio-metabolic health.Methods: We meta-analysed the association between DNA methylation at GFI1-locus with maternal prenatal smoking, adult own smoking, and cardio-metabolic phenotypes in 22 population-based studies from Europe, Australia, and USA (n= 18,212). DNA methylation at the GFI1-locus was measured in whole-blood. Multivariable regression models were fitted to examine its association with exposure to prenatal and own adult smoking. DNA methylation levels were analysed in relation to body mass index (BMI), waist circumference (WC), fasting glucose (FG), high-density lipoprotein cholesterol (HDL-C), triglycerides (TG), diastolic, and systolic blood pressure (BP).Findings: Lower DNA methylation at three out of eight GFI1-CpGs was associated with exposure to maternal prenatal smoking, whereas, all eight CpGs were associated with adult own smoking. Lower DNA methylation at cg14179389, the strongest maternal prenatal smoking locus, was associated with increased WC and BP when adjusted for sex, age, and adult smoking with Bonferroni-corrected P Interpretation: Epigenetic changes at the GFI1 were linked to smoking exposure in-utero/in-adulthood and robustly associated with cardio-metabolic risk factors. Fund: European Union's Horizon 2020 research and innovation programme under grant agreement no. 633595 DynaHEALTH. (c) 2018 The Authors. Published by Elsevier B.V. |
| وصف الملف: | application/pdf; fulltext |
| اللغة: | English |
| تدمد: | 2352-3964 |
| DOI: | 10.1016/j.ebiom.2018.10.066 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a6b430c483a243291b1142e2d449680Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....2a6b430c483a243291b1142e2d449680 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 23523964 |
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| DOI: | 10.1016/j.ebiom.2018.10.066 |