دورية أكاديمية
Study Protocol: The Heart and Brain Study
| العنوان: | Study Protocol: The Heart and Brain Study |
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| المؤلفون: | Suri, S, Bulte, D, Chiesa, ST, Ebmeier, KP, Jezzard, P, Rieger, SW, Pitt, JE, Griffanti, L, Okell, TW, Craig, M, Chappell, MA, Blockley, NP, Kivimäki, M, Singh-Manoux, A, Khir, AW, Hughes, AD, Deanfield, JE, Jensen, DEA, Green, SF, Sigutova, V, Jansen, MG, Zsoldos, E, Mackay, CE |
| بيانات النشر: | Frontiers Media SA |
| سنة النشر: | 2021 |
| المجموعة: | Brunel University London: Brunel University Research Archive (BURA) |
| مصطلحات موضوعية: | ageing, MRI, cerebrovascular reactivity, cognition, dementia prevention, longitudinal cohort, ultrasound, heart-brain |
| الوصف: | Copyright © 2021 Suri, Bulte, Chiesa, Ebmeier, Jezzard, Rieger, Pitt, Griffanti, Okell, Craig, Chappell, Blockley, Kivimäki, Singh-Manoux, Khir, Hughes, Deanfield, Jensen, Green, Sigutova, Jansen, Zsoldos and Mackay. Background: It is well-established that what is good for the heart is good for the brain. Vascular factors such as hypertension, diabetes, and high cholesterol, and genetic factors such as the apolipoprotein E4 allele increase the risk of developing both cardiovascular disease and dementia. However, the mechanisms underlying the heart–brain association remain unclear. Recent evidence suggests that impairments in vascular phenotypes and cerebrovascular reactivity (CVR) may play an important role in cognitive decline. The Heart and Brain Study combines state-of-the-art vascular ultrasound, cerebrovascular magnetic resonance imaging (MRI) and cognitive testing in participants of the long-running Whitehall II Imaging cohort to examine these processes together. This paper describes the study protocol, data pre-processing and overarching objectives. Methods and Design: The 775 participants of the Whitehall II Imaging cohort, aged 65 years or older in 2019, have received clinical and vascular risk assessments at 5-year-intervals since 1985, as well as a 3T brain MRI scan and neuropsychological tests between 2012 and 2016 (Whitehall II Wave MRI-1). Approximately 25% of this cohort are selected for the Heart and Brain Study, which involves a single testing session at the University of Oxford (Wave MRI-2). Between 2019 and 2023, participants will undergo ultrasound scans of the ascending aorta and common carotid arteries, measures of central and peripheral blood pressure, and 3T MRI scans to measure CVR in response to 5% carbon dioxide in air, vessel-selective cerebral blood flow (CBF), and cerebrovascular lesions. The structural and diffusion MRI scans and neuropsychological battery conducted at Wave MRI-1 will also be repeated. Using this extensive life-course data, the Heart and Brain Study will examine ... |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | 1 - 19 (19); Electronic |
| اللغة: | English |
| تدمد: | 1664-042X |
| العلاقة: | Frontiers in Physiology; 675721; Suri, S., Bulte, D., Chiesa, S.T., Ebmeier, K.P., Jezzard, P., Rieger, S.W., Pitt, J.E., Griffanti, L., Okell, T.W., Craig, M., Chappell, M.A., Blockley, N.P., Kivimäki, M., Singh-Manoux, A., Khir, A.W., Hughes, A.D., Deanfield, J.E., Jensen, D.E.A., Green, S.F., Sigutova, V., Jansen, M.G., Zsoldos, E. and Mackay, C.E. (2021) 'Study Protocol: The Heart and Brain Study', Frontiers in Physiology, 12, 643725, pp. 1-xx. doi:10.3389/fphys.2021.643725.; https://bura.brunel.ac.uk/handle/2438/22969Test; https://doi.org/10.3389/fphys.2021.643725Test |
| DOI: | 10.3389/fphys.2021.643725 |
| الإتاحة: | https://doi.org/10.3389/fphys.2021.643725Test https://bura.brunel.ac.uk/handle/2438/22969Test |
| حقوق: | Copyright © 2021 Suri, Bulte, Chiesa, Ebmeier, Jezzard, Rieger, Pitt, Griffanti, Okell, Craig, Chappell, Blockley, Kivimäki, Singh-Manoux, Khir, Hughes, Deanfield, Jensen, Green, Sigutova, Jansen, Zsoldos and Mackay. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. ; https://creativecommons.org/licenses/by/4.0Test/ |
| رقم الانضمام: | edsbas.7403B33D |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 1664042X |
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| DOI: | 10.3389/fphys.2021.643725 |