دورية أكاديمية
Characteristics of Misclassified CT Perfusion Ischemic Core in Patients with Acute Ischemic Stroke
| العنوان: | Characteristics of Misclassified CT Perfusion Ischemic Core in Patients with Acute Ischemic Stroke |
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| المؤلفون: | Geuskens, Ralph R. E. G., Borst, Jordi, Lucas, Marit, Boers, A. M. Merel, Berkhemer, Olvert A., Roos, Yvo B. W. E. M., van Walderveen, Marianne A. A., Jenniskens, Sjoerd F. M., van Zwam, Wim H., Dippel, Diederik W. J., Majoie, Charles B. L. M., Marquering, Henk A. |
| المصدر: | Geuskens , R R E G , Borst , J , Lucas , M , Boers , A M M , Berkhemer , O A , Roos , Y B W E M , van Walderveen , M A A , Jenniskens , S F M , van Zwam , W H , Dippel , D W J , Majoie , C B L M , Marquering , H A & MR CLEAN Trial Investigators 2015 , ' Characteristics of Misclassified CT Perfusion Ischemic Core in Patients with Acute Ischemic Stroke ' , PLoS ONE , vol. 10 , .... |
| سنة النشر: | 2015 |
| المجموعة: | University of Groningen research database |
| مصطلحات موضوعية: | COMPUTED-TOMOGRAPHY PERFUSION, CEREBRAL-BLOOD-FLOW, TECHNICAL IMPLEMENTATIONS, BRAIN PERFUSION, THEORETIC BASIS, INFARCT VOLUME, PART 1, PENUMBRA, MAPS, SELECTION |
| الوصف: | Background CT perfusion (CTP) is used to estimate the extent of ischemic core and penumbra in patients with acute ischemic stroke. CTP reliability, however, is limited. This study aims to identify regions misclassified as ischemic core on CTP, using infarct on follow-up noncontrast CT. We aim to assess differences in volumetric and perfusion characteristics in these regions compared to areas that ended up as infarct on follow-up. Materials and Methods This study included 35 patients with >100 mm brain coverage CTP. CTP processing was performed using Philips software (IntelliSpace 7.0). Final infarct was automatically segmented on follow-up noncontrast CT and used as reference. CTP and follow-up noncontrast CT image data were registered. This allowed classification of ischemic lesion agreement (core on CTP: rMTT >= 145%, aCBV Results Median total CTP ischemic core volume was 49.7ml (IQR: 29.9ml-132ml); median misclassified ischemic core volume was 30.4ml (IQR: 20.9ml-77.0ml). Median FDR between patients was 62% (IQR: 49%-80%). Median relative mean transit time was 243% (IQR: 198%-289%) and 342% (IQR: 249%-432%) for misclassified and ischemic lesion agreement regions, respectively. Median absolute cerebral blood volume was 1.59 (IQR: 1.43-1.79) ml/100g (P Conclusion For all patients a considerable region of the CTP ischemic core is misclassified. CTP parameters significantly differed between ischemic lesion agreement and misclassified CTP ischemic core, suggesting that CTP analysis may benefit from revisions. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| DOI: | 10.1371/journal.pone.0141571 |
| الإتاحة: | https://doi.org/10.1371/journal.pone.0141571Test http://hdl.handle.net/11370/7de4c725-0bb5-4c84-b1eb-567b35670cfcTest https://research.rug.nl/en/publications/7de4c725-0bb5-4c84-b1eb-567b35670cfcTest https://pure.rug.nl/ws/files/34677034/journal.pone.0141571.PDFTest |
| حقوق: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.3866841 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1371/journal.pone.0141571 |
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