التفاصيل البيبلوغرافية
| العنوان: |
Frequency and temporal profile of recanalization after cerebral vein and sinus thrombosis. |
| المؤلفون: |
Herweh, C.1, Griebe, M.2, Geisbüsch, C.3, Szabo, K.2, Neumaier ‐ Probst, E.4, Hennerici, M. G.2, Bendszus, M.1, Ringleb, P. A.3, Nagel, S.3 |
| المصدر: |
European Journal of Neurology. Apr2016, Vol. 23 Issue 4, p681-687. 7p. |
| مصطلحات موضوعية: |
*THROMBOSIS, *CARDIOVASCULAR disease treatment, *VENOUS thrombosis, *SINUS thrombosis, *CEREBRAL veins, *BLOOD coagulation, *DISEASES, *PROGNOSIS, *PREVENTION |
| مستخلص: |
Background and purpose The temporal course of recanalization and its association with clinical outcome were analysed in our patients with cerebral sinus and/or venous thrombosis ( CSVT) and follow-up magnetic resonance imaging ( MRI). Methods Between January 1998 and September 2014 all patients from our institutions with CSVT were systematically analysed. Baseline data, treatment characteristics and follow-up MRI were retrospectively recorded. The status of recanalization was assessed as complete ( CRec), partial ( PRec) or failed recanalization. Clinical follow-up was measured with the modified Rankin Scale. Excellent outcome was defined as modified Rankin Scale 0-1. Results Ninety-nine patients were identified; 97% of these patients were treated with oral anticoagulation ( OAC) and the median (min-max) time of OAC was 7 months (1-84). CRec was achieved in 57.6% (57/99), PRec in 29.3% (29/99) and only 13 (13.1%) patients did not recanalize. The median (min-max) time to PRec was 4 months (0.25-14) and to CRec 6 months (2-34). Median time to last clinical follow-up was 8 months (1-88); 91.8% (89/99) had an excellent outcome at last clinical follow-up and only 2.1% (2/99) died. Only thrombosis of the superior sagittal sinus was independently associated with successful recanalization (odds ratio 16, 95% confidence interval 2-138). No severe haemorrhagic complications and no recurrence of CSVT occurred within clinical follow-up. No association of outcome and recanalization status was found. Conclusions The recanalization rate of CSVT under OAC was high and the median time to CRec was 6 months. Thrombosis of the superior sagittal sinus is a positive predictor of recanalization. Outcome in this cohort was excellent but no significant association of outcome and recanalization status was found. [ABSTRACT FROM AUTHOR] |
| قاعدة البيانات: |
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