التفاصيل البيبلوغرافية
| العنوان: |
Epstein- Barr virus-associated primary central nervous system cytotoxic T-cell lymphoma. |
| المؤلفون: |
Ogura, Ryosuke, Aoki, Hiroshi, Natsumeda, Manabu, Shimizu, Hiroshi, Kobayashi, Tsutomu, Saito, Tomohisa, Takizawa, Jun, Okamoto, Kouichirou, Hasegawa, Go, Umezu, Hajime, Ohshima, Kouichi, Takahashi, Hitoshi, Fujii, Yukihiko, Kakita, Akiyoshi |
| المصدر: |
Neuropathology; Aug2013, Vol. 33 Issue 4, p436-441, 6p, 1 Color Photograph, 2 Black and White Photographs, 1 Chart |
| مصطلحات موضوعية: |
EPSTEIN-Barr virus, CENTRAL nervous system, CYTOTOXIC T cells, PHENOTYPES, CEREBRAL hemispheres, IMMUNOHISTOCHEMISTRY, ANTIGENS |
| مستخلص: |
Primary central nervous system lymphoma ( PCNSL) expressing T-cell markers is rare, among which nasal-type extranodal NK/T-cell lymphoma is an extremely rare subtype associated with Epstein- Barr virus ( EBV) infection. Here we report the clinicopathologic features of a case of EBV-associated PCNSL showing a cytotoxic T-cell phenotype. The patient, a 73-year-old woman, presented with rapidly progressive mental deterioration. Brain MRI revealed multiple lesions with swelling in the bilateral cerebral hemispheres, which were hypointense on T1-weighted images, hyperintense on T2-weighted and fluid-attenuated inversion recovery images, and slightly hyperintense on diffusion-weighted images. Biopsy specimens from the temporal region showed many medium-sized anaplastic lymphocytic cells with perivascular and angio-invasive patterns in the cortex. Immunohistochemically, the cells were positive for CD3, CD8, T-cell-restricted intracellular antigen-1 ( TIA-1), granzyme B and perforin, but negative for CD56 and CD20. In situ hybridization revealed EBV-encoded RNAs in the tumor cell nuclei. A rearrangement study showed T-cell receptor γ-chain gene rearrangement with a clonal appearance. The patient died 6 months after surgery, and a general autopsy revealed no lymphoma cells outside the brain. These cellular profiles are inconsistent with those of extranodal NK/T-cell lymphoma, and have not been previously described. This case appears to represent an unusual CNS manifestation of EBV-associated T-cell lymphoma. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
