التفاصيل البيبلوغرافية
| العنوان: |
Management of haemorrhagic stroke secondary to arteriovenous malformations in childhood. |
| المؤلفون: |
Bal, Jarnail, Milosevich, Elise, Rennie, Adam, Robertson, Fergus, Toolis, Claire, Bhate, Sanjay, James, Greg, Ganesan, Vijeya |
| المصدر: |
Child's Nervous System; Apr2021, Vol. 37 Issue 4, p1255-1265, 11p |
| مصطلحات موضوعية: |
CEREBRAL embolism & thrombosis, VENOUS thrombosis, CEREBRAL arteriovenous malformations, GLASGOW Coma Scale, COMBINED modality therapy, ARTERIOVENOUS malformation, DIAGNOSTIC imaging |
| مصطلحات جغرافية: |
UNITED Kingdom |
| مستخلص: |
Aims: The aim of this study is to describe the outcome and management of all children who have presented with haemorrhagic stroke (HS) secondary to an arteriovenous malformation (AVM) at a single UK centre over a 13-year period. Methods: All children with HS managed at our institution (2005–2018) were identified and those with underlying AVMs were studied. Clinical and imaging data were obtained from medical records. Outcome was scored using the Recovery and Recurrence Questionnaire. Results: Ninety-three children (median age 8.8 years; 56 males; 8 neonates) presented with both global and focal features (28 had Glasgow Coma Score < 8). Haemorrhage was intraparenchymal in 72; prior risk factors present in 14. An underlying vascular lesion was identified in 68/93, most commonly AVM (n = 48). A systemic cause was found in 10, cerebral venous thrombosis in three, and 9 remain unidentified despite neuroradiological investigation. Median follow-up was 2.4 years, six died, and one was lost to follow-up. Outcome was rated as good in 60/86. Of the 48 AVMs, 3 were Spetzler-Martin (SM) grade 1, 21 SM 2, 21 SM3 and 3 SM4. One patient was treated conservatively as the AVM was too high risk to treat. At follow-up, 19 with AVM were angiographically cured, all with low SM grade and with the use of a single modality in 9 cases (all low SM grade). Conclusion: Although children with acute HS are extremely unwell at presentation, supportive care results in a good outcome in the majority. Complete obliteration for childhood AVMs is challenging even with low-grade lesions with multimodal treatment. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
