التفاصيل البيبلوغرافية
| العنوان: |
The gut microbiota in retinal diseases. |
| المؤلفون: |
Bringer, Marie-Agnès1 (AUTHOR) marie-agnes.bringer@inrae.fr, Gabrielle, Pierre-Henry1,2 (AUTHOR), Bron, Alain M.1,2 (AUTHOR), Creuzot-Garcher, Catherine1,2 (AUTHOR), Acar, Niyazi1 (AUTHOR) |
| المصدر: |
Experimental Eye Research. Jan2022, Vol. 214, pN.PAG-N.PAG. 1p. |
| مصطلحات موضوعية: |
*GUT microbiome, *RETINAL diseases, *CENTRAL nervous system diseases, *DIABETIC retinopathy, *METABOLIC disorders |
| مستخلص: |
The gut microbiota is a complex ecosystem that inhabits the gastrointestinal tract and consists of archaea, fungi, viruses, and bacteria, with bacteria being dominant. From birth onwards, it coevolves dynamically together with the host. The composition of the gut microbiota is under the influence of a complex interplay between both host and environmental factors. Scientific advances in the past few decades have shown that it is essential in maintaining homeostasis and tipping the balance between health and disease. In addition to its role in food digestion, the gut microbiota is implicated in regulating multiple physiological processes in the host gut mucosa and in distant organs such as the brain. Persistent imbalance between gut microbial communities, termed "dysbiosis," has been associated with several inflammatory and metabolic diseases as well as with central nervous system disorders. In this review, we present the state of the art of current knowledge on an emerging concept, the microbiota–retina axis, and the potential role of its disturbance in the development of retinopathies. We also describe several microbiota-targeting strategies that could constitute preventive and therapeutic tools for retinopathies. • Studies in humans suggest that dysbiosis is associated with retinopathies. • Current data indicate that the gut microbiota influences retinal physiology. • Microbiota-targeting strategies could constitute tools for retinopathies. [ABSTRACT FROM AUTHOR] |
| قاعدة البيانات: |
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