التفاصيل البيبلوغرافية
| العنوان: |
Molecular dysregulations underlying the pathogenesis of endometriosis. |
| المؤلفون: |
Balasubramanian, Vaishnavi1 (AUTHOR), Saravanan, Roshni1 (AUTHOR), Joseph, Leena Dennis2 (AUTHOR), Dev, Bhawna3 (AUTHOR), Gouthaman, Shanmugasundaram4 (AUTHOR), Srinivasan, Bhuvana5 (AUTHOR), Dharmarajan, Arun6 (AUTHOR), Rayala, Suresh Kumar7 (AUTHOR), Venkatraman, Ganesh1 (AUTHOR) ganeshv@sriramachandra.edu.in |
| المصدر: |
Cellular Signalling. Dec2021, Vol. 88, pN.PAG-N.PAG. 1p. |
| مصطلحات موضوعية: |
*ENDOMETRIOSIS, *PATHOGENESIS, *EPITHELIAL-mesenchymal transition, *CELLULAR signal transduction, *DRUG target, *DIAGNOSIS |
| مستخلص: |
Endometriosis is a crippling disease characterized by the presence of endometrium-like tissue or scar outside the uterine cavity, commonly confined to the peritoneal and serosal surfaces of the pelvic organs. 10–15% of women in reproductive age are estimated to be affected by endometriosis. Most of these patients present with infertility and suffer from pelvic pain. The benign disease rarely progresses to malignancy. Regardless of its high prevalence, the pathogenesis of the disease is not fully understood. Treatment options for endometriosis are limited and are often based on a symptomatic approach. The unavailability of proper diagnostic approaches, fewer therapeutic options, and sparse understanding of molecular alterations are responsible for the continued disease burden. Exploring the molecular elements causing the pathogenesis of endometriosis may lead to a number of breakthroughs in the treatment of the illness, such as the discovery of new biomarkers for diagnosis and therapeutic targets that can be a guide to better prognosis and reduced recurrence. The goal of this review is to provide the reader a critical understanding of the disease by summarizing the genetic, immunological, hormonal, and epigenetic deregulations that support the molecular basis for development of endometriotic cyst, with a special focus on the study models needed to analyze these changes in the endometriotic microenvironment. • Endometriosis is a complicated disease with poor prognosis, recurrence, limited treatment strategies and limited intervention on the aspects of pathogenesis. • The complexity of the disease corresponds to disruption in the various signaling pathways that play an essential role in Inflammation, Hormonal imbalance, Oxidative Stress, Epithelial Mesenchymal Transition, Carcinogenesis, Immunity and Epigenetic regulations • Understanding these alterations and dysregulations may provide a clue to recognize the lead biomarkers that are causative for the pathogenesis of endometriosis. • Study models of endometriosis assists in identifying a complete picture of these molecular alterations and pave way for better diagnosis and treatment options. [ABSTRACT FROM AUTHOR] |
| قاعدة البيانات: |
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