دورية أكاديمية
Sex-specific deficits in neurite density and white matter integrity are associated with targeted disruption of exon 2 of the Disc1 gene in the rat
| العنوان: | Sex-specific deficits in neurite density and white matter integrity are associated with targeted disruption of exon 2 of the Disc1 gene in the rat |
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| المؤلفون: | Barnett, Brian R., Torres-Velázquez, Maribel, Yi, Sue Y., Rowley, Paul A., Sawin, Emily A., Rubinstein, C. Dustin, Krentz, Kathleen, Anderson, Jacqueline M., Bakshi, Vaishali P., Yu, John-Paul J. |
| المساهمون: | Brain and Behavior Research Foundation, U.S. Department of Health & Human Services | National Institutes of Health, U.S. Department of Health & Human Services | NIH | National Center for Advancing Translational Sciences |
| المصدر: | Translational Psychiatry ; volume 9, issue 1 ; ISSN 2158-3188 |
| بيانات النشر: | Springer Science and Business Media LLC |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | Biological Psychiatry, Cellular and Molecular Neuroscience, Psychiatry and Mental health |
| الوصف: | Diffusion tensor imaging (DTI) has provided remarkable insight into our understanding of white matter microstructure and brain connectivity across a broad spectrum of psychiatric disease. While DTI and other diffusion weighted magnetic resonance imaging (MRI) methods have clarified the axonal contribution to the disconnectivity seen in numerous psychiatric diseases, absent from these studies are quantitative indices of neurite density and orientation that are especially important features in regions of high synaptic density that would capture the synaptic contribution to the psychiatric disease state. Here we report the application of neurite orientation dispersion and density imaging (NODDI), an emerging microstructure imaging technique, to a novel Disc1 svΔ2 rat model of psychiatric illness and demonstrate the complementary and more specific indices of tissue microstructure found in NODDI than those reported by DTI. Our results demonstrate global and sex-specific changes in white matter microstructural integrity and deficits in neurite density as a consequence of the Disc1 svΔ2 genetic variation and highlight the application of NODDI and quantitative measures of neurite density and neurite dispersion in psychiatric disease. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1038/s41398-019-0429-2 |
| الإتاحة: | https://doi.org/10.1038/s41398-019-0429-2Test https://www.nature.com/articles/s41398-019-0429-2.pdfTest https://www.nature.com/articles/s41398-019-0429-2Test |
| حقوق: | https://creativecommons.org/licenses/by/4.0Test ; https://creativecommons.org/licenses/by/4.0Test |
| رقم الانضمام: | edsbas.87BFAC2F |
| قاعدة البيانات: | BASE |
| DOI: | 10.1038/s41398-019-0429-2 |
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