Glutathione-Allylsulfur Conjugates as Mesenchymal Stem Cells Stimulating Agents for Potential Applications in Tissue Repair
| العنوان: | Glutathione-Allylsulfur Conjugates as Mesenchymal Stem Cells Stimulating Agents for Potential Applications in Tissue Repair |
|---|---|
| المؤلفون: | Silvia Buonvino, Emilia Di Giovanni, Ivano Amelio, Sonia Melino |
| المساهمون: | Melino, Sonia [0000-0001-7694-5279], Apollo - University of Cambridge Repository |
| المصدر: | International Journal of Molecular Sciences International Journal of Molecular Sciences, Vol 21, Iss 5, p 1638 (2020) Volume 21 Issue 5 |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | cell migration, Transcription, Genetic, hydrogen sulfide, garlic, regenerative medicine, oxidative stress, MSCs, organosulfur compounds, cell differentiation, Cellular differentiation, medicine.medical_treatment, Cell Plasticity, Regenerative medicine, Antioxidants, lcsh:Chemistry, Cell Movement, lcsh:QH301-705.5, Spectroscopy, Cell Differentiation, General Medicine, Stem-cell therapy, Glutathione, Cell Hypoxia, Computer Science Applications, Phenotype, Cardiovascular Diseases, Inactivation, Metabolic, Stem cell, Cell Survival, Mesenchymal Stem Cell Transplantation, Catalysis, Article, Inorganic Chemistry, ddc:570, medicine, Humans, Settore BIO/10, Physical and Theoretical Chemistry, Molecular Biology, Cell Proliferation, Wound Healing, Sulfur Compounds, Cell growth, business.industry, Myocardium, Organic Chemistry, Mesenchymal stem cell, Mesenchymal Stem Cells, Fibroblasts, equipment and supplies, Transplantation, lcsh:Biology (General), lcsh:QD1-999, Gene Expression Regulation, Cancer research, business, Biomarkers, Homing (hematopoietic) |
| الوصف: | The endogenous gasotransmitter H2S plays an important role in the central nervous, respiratory and cardiovascular systems. Accordingly, slow-releasing H2S donors are powerful tools for basic studies and innovative pharmaco-therapeutic agents for cardiovascular and neurodegenerative diseases. Nonetheless, the effects of H2S-releasing agents on the growth of stem cells have not been fully investigated. H2S preconditioning can enhance mesenchymal stem cell survival after post-ischaemic myocardial implantation therefore, stem cell therapy combined with H2S may be relevant in cell-based therapy for regenerative medicine. Here, we studied the effects of slow-releasing H2S agents on the cell growth and differentiation of cardiac Lin&minus Sca1+ human mesenchymal stem cells (cMSC) and on normal human dermal fibroblasts (NHDF). In particular, we investigated the effects of water-soluble GSH&ndash garlic conjugates (GSGa) on cMSC compared to other H2S-releasing agents, such as Na2S and GYY4137. GSGa treatment of cMSC and NHDF increased their cell proliferation and migration in a concentration dependent manner with respect to the control. GSGa treatment promoted an upregulation of the expression of proteins involved in oxidative stress protection, cell&ndash cell adhesion and commitment to differentiation. These results highlight the effects of H2S-natural donors as biochemical factors that promote MSC homing, increasing their safety profile and efficacy after transplantation, and the value of these donors in developing functional 3D-stem cell delivery systems for cardiac muscle tissue repair and regeneration. |
| وصف الملف: | application/pdf; application/zip; text/xml |
| اللغة: | English |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9faf48cde51aebcedc83c1f87cca5dbTest |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....e9faf48cde51aebcedc83c1f87cca5db |
| قاعدة البيانات: | OpenAIRE |
| الوصف غير متاح. |