المؤلفون: Kaneez Fatima, Abha Meena, Suaib Luqman, Nusrat Masood, Zahoor Ahmad Wani

المصدر: Journal of Advanced Research

مصطلحات موضوعية: TRIG, Triglyceraldehyde, Skin Neoplasms, Cell, DOXO, Doxorubicin, Hyaluronidase, Pharmacology, NaOH, Sodium hydroxide, Polymerization, MTT, 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide, Mice, 0302 clinical medicine, BIL, Bilirubin total & direct, Neomenthol, PEP A, pepstatin A, Cancer biomarker, MEF, Mean erythrocyte fragility, HYAL, Hyaluronidase, PBS, Phosphate buffer saline, CM-H2DCFDA, Chloromethyl derivative of dichloro fluorescin diacetate, HA, Hyaluronic acid, Epidermoid carcinoma, Human epidermoid carcinoma, 030220 oncology & carcinogenesis, RBC, Red blood cell, DMEM, Dulbecco’s minimal essential media, SRB, Sulphorhodamine B, BUN, Blood urea nitrogen, FACS, Fluorescence-Activated Cell Sorting, AKLP, Alkaline phosphatase, Hyaluronoglucosaminidase, NADPH, Nicotinamide adenine dinucleotide phosphate hydrogen, TMPD, N,N,N′,N′-tetramethyl-p-phenylenediamine, Article, 03 medical and health sciences, In vivo, Ehrlich Ascites Carcinoma, BE, Binding energy, Humans, CATD, Cathepsin D, LDH, Lactate dehydrogenase, COX-2, Cyclooxygenase 2, FOX, Ferrous oxidation-xylenol orange, DMSO, Dimethyl sulfoxide, mTOR, Mammalian target of rapamycin, In vitro, Ab/Am, Antibiotic/antimycotic, NRU, Neutral red uptake, EC50, Half maximal effective concentration, 030104 developmental biology, IC50, Half maximal inhibitory concentration, EAC, Ehlrich Ascites Carcinoma, RPMI, Roswell park memorial institute, ROS, Reactive oxygen species, 0301 basic medicine, HDL, High density lipoprotein, TNBS, Trinitrobenzenesulphonic acid, PI3K, Phosphotidyl inositol-3 kinase, URIC, Uric acid, DNA, Deoxyribonucleic acid, GAPDH, Glyceraldehyde 3-phosphate dehydrogenase, HEPES, N-2-hydroxyethylpiperazine-N′-2-ethanesulfonic acid, Tubulin, OECD, Organization for Economic Co-operation and Development, SGPT, Alanine aminotransferase, LOX-5, Lipoxygenase-5, DFMO, α-difluoro methyl ornithine, Multidisciplinary, WBC, White blood cell, Chemistry, ELISA, enzyme-linked immunosorbent assay, PKB/Akt, Protein kinase B, AA, Arachidonic acid, RNase A, Ribonuclease A, TPR, Total protein, Molecular Docking Simulation, medicine.anatomical_structure, TCA, Tricarboxylic acid, CHOL, Cholesterol, Ki, Inhibitory constant, medicine.drug, ODC, Ornithine decarboxylase, DHFR, Dihydrofolatereductase, BSA, Bovine serum albumin, PDB, Protein Data Bank, medicine, Animals, MMP, Mitochondrial membrane potential, DCFDA, 2′,7′ dichloro fluorescin diacetate, RNA, Ribonucleic acid, RIPA, Radio immune precipitation assay buffer, EDTA, Ethylene diamine tetra acetic acid, IC50, TPA, 12-O-Tetradecanoylphorbol-13-acetate, ComputingMethodologies_COMPUTERGRAPHICS, TRPM8, Transient receptor potential member 8, Cell Proliferation, HDAC, Histone deacetylase, MTX, Methotrexate, OF, Osmotic fragility, PI, Propidium iodide, FDA, Food and Drug Administration, HEK293 Cells, PDT, Podophyllotoxin, Cell culture, NAC, N-acetyl cysteine, SGOT, Aspartate aminotransferase, CRTN, Creatinine, FBS, Fetal bovine serum, PCR, Polymerase chain reaction, Rh123, Rhodamine 123, Ex vivo, IDT, Integrated DNA Technologies

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7618e7dc6e2d535e1930d5f8c2bf7d7eTest
https://doi.org/10.1016/j.jare.2021.06.003Test

المؤلفون: Hsin Ming Chen, Jeng Fan Lo, Ching Wen Chang, Yi Fen Chen, Tz Yu Kuo, Chung Ji Liu, Hao Yuan Chia, Chia Yi Chou, Pei Chun Huang, Tsai Ying Chen, Wan Chun Li, Lu Te Chuang, Yi Ta Hsieh, Jian Min Huang

المصدر: Neoplasia: An International Journal for Oncology Research, Vol 21, Iss 7, Pp 641-652 (2019)
Neoplasia (New York, N.Y.)

مصطلحات موضوعية: PGAM1, Phosphoglycerate mutase 1, 0301 basic medicine, Cancer Research, LC–MS, Liquid chromatography-mass spectrophotometry, Carcinogenesis, 5-FU, 5-fluouracil, ALDH, Aldehyde dehydrogenase, ACACB, Acetyl-CoA carboxylase beta, INN, Silibinin, medicine.disease_cause, Mice, 0302 clinical medicine, EMT, Epithelial-mesenchymal transition, PDHA1, Pyruvate dehydrogenase E1 component α subunit, Pyruvic Acid, OxPhos, Oxidative phosphorylation, PKM2, Pyruvate kinase M2, PUFAs, Polyunsaturated fatty acids, Glycolysis, ENO, Enolase, DON, 6-diazo-5-oxo-L-norlucine, education.field_of_study, Chemistry, Kinase, ABC, ATP-binding cassette, MTT, 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide, ERK, Extracellular signal-regulated kinase, PKB/Akt, Protein kinase B, 4-NQO, 4-nitroquinoline 1-oxide, lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens, GC-FID, Gas chromatograph-flame ionization detector, MUFAs, Monounsaturated fatty acids, Mitochondria, NHOK, Normal human oral keratinocytes, SCD1, Stearoyl-CoA desaturase 1, 030220 oncology & carcinogenesis, PDC, Pyruvate dehydrogenase complex, Heterografts, SFAs, Saturated fatty acids, TCA, Tricarboxylic acid, GLUD1/2, Glutamine dehydrogenase 1/2, Original article, G3PDH, Glyceraldehyde-3-phosphate dehydrogenase, TCGA, The Cancer Genomic Atlas, Catalytic complex, Lactate dehydrogenase A, DLD, Dihydrolipoamide dehydrogenase, lcsh:RC254-282, DCA, Dicholoroacetate, 03 medical and health sciences, ECM, Extracellular matrix, FASN, Fatty acid synthase, CDDP, Cisplatin, Cell Line, Tumor, HNSCC, Head and neck squamous cell carcinoma, medicine, shRNA, short-hairpin RNA, Animals, Humans, Pyruvate Dehydrogenase (Lipoamide), TAXOL, Paclitaxel, Lactic Acid, SREBF1/2, Sterol regulatory element-binding transcription factor 1/2, education, Protein kinase B, DLAT, Dihydrolipoamide S-acetyltransferase, PDK1, Pyruvate dehydrogenase kinase 1, Cell Proliferation, PPP, Pentose phosphate pathway, L-Lactate Dehydrogenase, LDHA, Lactate dehydrogenase A, Squamous Cell Carcinoma of Head and Neck, Cell growth, hOSCC, human oral squamous cell carcinoma, Gluts, Glucose transporters, medicine.disease, Head and neck squamous-cell carcinoma, OCR, Oxygen consumption rate, EGCG, Epigallocatechin gallate, 030104 developmental biology, PFK1, Phosphofructokinase 1, OS, Overall survival, PDP1, Pyruvate dehydrogenase phosphatase 1, IC50, Half maximal inhibitory concentration, Cancer research, PEP, Phosphoenolpyruvate, GLS1, Glutaminase 1, ROS, Reactive oxygen species

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92754b6cd8bfc62335acf4065f363f43Test
https://doi.org/10.1016/j.neo.2019.04.007Test

المؤلفون: Naga Padma Lakshmi Ch, Sebastian Raja, Sundarasamy Mahalingam, Ananthi Sivagnanam

المصدر: The Journal of Biological Chemistry

مصطلحات موضوعية: 0301 basic medicine, GADD45a, growth arrest and DNA damage–inducible alpha, GADD45a, RNF2, Biology, ubiquitination, Biochemistry, BrdU, bromodeoxyuridine, MTT, 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide, 03 medical and health sciences, proteomics, CHX, cycloheximide, Stomach Neoplasms, Cell Line, Tumor, CDC2 Protein Kinase, medicine, Humans, Molecular Biology, Mitosis, Cell Proliferation, mitosis, Polycomb Repressive Complex 1, TCGA, the cancer genome atlas, Cyclin-dependent kinase 1, 030102 biochemistry & molecular biology, NPM, nucleophosmin, Cell growth, gastric cancer, RNF2, ring finger protein 2, Nuclear Proteins, Cancer, APC, anaphase-promoting complex, MS, Cell Biology, DNA Methylation, Cell cycle, medicine.disease, Ubiquitin ligase, Gene Expression Regulation, Neoplastic, 030104 developmental biology, RASSF, Ras-association domain family, biology.protein, Cancer research, RASSF10, Anaphase-promoting complex, nucleophosmin, GADD45A, Research Article

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29d5f6290d3c05db565036ae36f08109Test
https://doi.org/10.1016/j.jbc.2021.100935Test

المؤلفون: Qi Cao, De-Chen Lin, H. Phillip Koeffler, Sumiko Takao, Mark Rolfe, Ronan Le Moigne, Markus Müschen, Sigal Gery, Gabriele Gugliotta, Haibo Sun, Makoto Sudo, Michele Cavo

المساهمون: Gugliotta, Gabriele, Sudo, Makoto, Cao, Qi, Lin, De-chen, Sun, Haibo, Takao, Sumiko, Le Moigne, Ronan, Rolfe, Mark, Gery, Sigal, Müschen, Marku, Cavo, Michele, Koeffler, H. Phillip

المصدر: Neoplasia (New York, N.Y.), vol 19, iss 10
Neoplasia: An International Journal for Oncology Research, Vol 19, Iss 10, Pp 750-761 (2017)
Neoplasia (New York, N.Y.)

مصطلحات موضوعية: PEI, polyethylenimine, 0301 basic medicine, Cancer Research, Apoptosis, ERAD, ER-associated degradation, MTT, 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide, Gene Knockout Techniques, chemistry.chemical_compound, UPR, unfolded protein response, Valosin Containing Protein, Molecular Targeted Therapy, Endoplasmic Reticulum Chaperone BiP, Tumor, Cell Cycle, Drug Synergism, Precursor Cell Lymphoblastic Leukemia-Lymphoma, lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens, Endoplasmic Reticulum Stress, Biochemistry, Signal Transduction, medicine.drug, Original article, Vincristine, Programmed cell death, XBP1, HNA, 2-hydroxy-1-naphthaldehyde, Cell Survival, Clinical Sciences, B-ALL, B acute lymphoblastic leukemia, Antineoplastic Agents, Biology, lcsh:RC254-282, 4-OHT, 4-hydroxy tamoxifen, Cell Line, ER, endoplasmic reticulum, PI, propidium iodide, 03 medical and health sciences, Cell Line, Tumor, medicine, Humans, Oncology & Carcinogenesis, Propidium iodide, Cell Proliferation, Endoplasmic reticulum, 030104 developmental biology, Gene Expression Regulation, chemistry, Cell culture, Unfolded Protein Response, Cancer research, Unfolded protein response, Biomarkers

وصف الملف: application/pdf; ELETTRONICO

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::513f1ad0f44ffe57cf442f239234105fTest
https://doi.org/10.1016/j.neo.2017.08.001Test

المؤلفون: Jiansong Ji, Ri Cui, Xiaoxi Fan, Peng Zou, Fazong Wu, Weiqian Chen, Xi Chen, Qianqian Zhang, Rajamanickam Vinothkumar, Guang Liang, Zhongwei Zhao

المصدر: Redox Biol
Redox Biology, Vol 10, Iss C, Pp 78-89 (2016)
Redox Biology

مصطلحات موضوعية: 0301 basic medicine, ATF4, activating transcription factor 4, Cytotoxicity, Clinical Biochemistry, PI, propidium Iodide, Pharmacology, Biochemistry, JC-1, cationic carbocyanine dye, MTT, 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide, Mice, 0302 clinical medicine, Antineoplastic Combined Chemotherapy Protocols, CHOP, CAAT/enhancer binding protein (C/EBP) homologous protein, cdc-2, cyclin-dependent kinase 1 (cell division cycle protein 2), lcsh:QH301-705.5, EF24, lcsh:R5-920, Kinase, HRP, horseradish peroxidase, Drug Synergism, Endoplasmic Reticulum Stress, PI3 kinase, phosphoinositide 3-kinase, Bcl2, B-cell lymphoma 2, Gene Expression Regulation, Neoplastic, DCF, dichlorodihydrofluorescein, mTORC, mTOR complex, 030220 oncology & carcinogenesis, FITC, fluorescein isothiocyanate, lcsh:Medicine (General), Corrigendum, Research Paper, PARP, poly (ADP-ribose) polymerase, medicine.drug, Cell Survival, mTOR, mammalian target of rapamycin, MDM-2, murine double minute 2, Biology, Benzylidene Compounds, eIF2, eukaryotic initiation factor 2, ER, endoplasmic reticulum, 03 medical and health sciences, ROS, reactive oxygen species, Stomach Neoplasms, Cell Line, Tumor, medicine, Animals, Humans, Rapamycin, Piperidones, PI3K/AKT/mTOR pathway, DCFH-DA, 2′, 7′-dichlorodihydrofluorescein diacetate, Cell Proliferation, MDA, malondialdehyde, Sirolimus, 4E-BP-1, eukaryotic initiation factor 4E binding protein-1, Ki-67, nuclear protein associated with cell proliferation, Cell growth, PERK, protein kinase RNA-like endoplasmic reticulum kinase, Organic Chemistry, JNK Mitogen-Activated Protein Kinases, Cancer, Antitumor, C/EBP, CAAT/enhancer binding protein, JNK, c-Jun N terminal kinase, medicine.disease, Xenograft Model Antitumor Assays, 030104 developmental biology, S6, S6 ribosomal protein, lcsh:Biology (General), Oxidative stress, Apoptosis, NAC, N-acetyl cysteine, Cancer cell, Unfolded protein response, Reactive Oxygen Species, Gastric cancer

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::996fc2e0f8970a6c0fa2b5a280f19672Test
https://doi.org/10.1016/j.redox.2016.09.006Test

المؤلفون: Amber Knox, Jelena Mann, Marina García-Macia, Laura Sabater, Eva Morán-Salvador, Agata Page, Fiona Oakley, Marco Y W Zaki, Saimir Luli, Ashwin Sivaharan, Derek A. Mann

المصدر: Gastroenterology

مصطلحات موضوعية: 0301 basic medicine, Male, WT, wild type, DNA Repair, Methyl-CpG-Binding Protein 2, Liver Cirrhosis, Experimental, Transcriptome, BrdU, bromodeoxyuridine, MTT, 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide, 0302 clinical medicine, lncRNA, MCM, maintenance protein complex, PCA, principal components analysis, CCl4, carbon tetrachloride, Serine, Epigenetic Factor, Phosphorylation, APAP, N-acetyl-ρ-aminophen, Carbon Tetrachloride, TGF, transforming growth factor, Cells, Cultured, Mice, Knockout, Kinase, Gastroenterology, Long non-coding RNA, mRNA, messenger RNA, 3. Good health, Cell biology, ECM, extracellular matrix, MMP, matrix metalloproteinase, 030211 gastroenterology & hepatology, Collagen, Chemical and Drug Induced Liver Injury, HSC, hepatic stellate cells, Signal Transduction, DNA Replication, congenital, hereditary, and neonatal diseases and abnormalities, α-SMA, α–smooth muscle actin, DNA repair, Biology, SEM, standard error of the mean, KEGG, Kyoto Encyclopedia of Genes and Genomes, Article, 03 medical and health sciences, Minichromosome maintenance, mental disorders, Hepatic Stellate Cells, Animals, Gene, Acetaminophen, Cell Proliferation, IPA, Ingenuity Pathway Analysis, Myofibroblast, Hepatology, MCM, qRT-PCR, quantitative reverse-transcription polymerase chain reaction, nervous system diseases, IL, interleukin, Mice, Inbred C57BL, 030104 developmental biology, siRNA, small interfering RNA, Hepatic stellate cell, lncRNA, long noncoding RNA

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2e6380589c589bd9e568baeb0c14dfcTest
https://pubmed.ncbi.nlm.nih.gov/31352003Test

المؤلفون: Elaine L, Ferguson, Sameza, Naseer, Lydia C, Powell, Joseph, Hardwicke, Fraser I, Young, Bangfu, Zhu, Qian, Liu, Bing, Song, David W, Thomas

المصدر: Stem Cell Research

مصطلحات موضوعية: DMF, N,N-dimethyl formamide, Cell Culture Techniques, PLGA, poly(lactic-co-glycolic acid), DMSO, dimethyl sulfoxide, Biodegradable polymers, Article, Olig2, oligodendrocyte transcription factor, MAP2, microtubule-associated protein 2, MTT, 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide, SCI, spinal cord injury, DNA, deoxyribonucleic acid, FPLC, fast protein liquid chromatography, Neural Stem Cells, PBS, phosphate buffered saline, Dextrins, TUNEL, terminal deoxynucleotidyl transferase (TdT) dUTP nick-end labelling, Humans, DMAP, 4-dimethylaminopyridine, Controlled release, EDC, 1-ethyl-3-(3-dimethylaminopropyl carbodiimide hydrochloride), mNSC, mouse neural stem cell, Cell Proliferation, EMEM, eagle's minimum essential media, EGF, epidermal growth factor, bFGF, basic fibroblast growth factor (FGF-2), GFAP, glial fibrillary acidic protein, Cell Differentiation, CLSM, confocal laser scanning microscopy, GPC, gel permeation chromatography, BCA, bicinchoninic acid, HAMC, hyaluronan and methyl cellulose, Fibroblast Growth Factor 2, sulfo-NHS, N-hydroxysulfosuccinimide, FCS, fetal calf serum, GF, growth factor, NSC, neural stem cell, Polymer therapeutics, Growth factors, Hep2, human epidermoid carcinoma

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=pmid________::814be96b8e015a323c90b0cbb0a6f467Test
https://pubmed.ncbi.nlm.nih.gov/30321831Test

المؤلفون: Maja Köhn, Birgit Hoeger, Maren Diether, Pedro J. Ballester

المصدر: European Journal of Medicinal Chemistry

مصطلحات موضوعية: USR, ultrafast shape recognition, Thienopyridone, Protein tyrosine phosphatase, ROCS, rapid overlay of chemical structures, VS, virtual screening, 2-Cyano-2-ene-esters, Molecular Docking Simulation, MTT, 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide, PTP1B, protein tyrosine phosphatase 1B, Cell Movement, Neoplasms, Drug Discovery, Enzyme Inhibitors, Cells, Cultured, Molecular Structure, Chemistry, Phosphatases of regenerating liver, TCPTP, T-cell protein tyrosine phosphatase, General Medicine, Small molecule, 3. Good health, Liver, Biochemistry, Original Article, DSP, dual specificity phosphatase, PTP, protein tyrosine phosphatase, PRL, phosphatases of regenerating liver, Cell Survival, UFSRAT, ultrafast shape recognition with atom types, DIFMUP, 6,8-difluoro-4-methylumbelliferyl phosphate, Small Molecule Libraries, Structure-Activity Relationship, SAR, structure–activity relationship, Humans, Structure–activity relationship, Dual specificity phosphatases, Cell Proliferation, Pharmacology, Virtual screening, UPLC-MS, ultra performance liquid chromatography–mass spectrometry, Dose-Response Relationship, Drug, Cell growth, Organic Chemistry, Phosphoric Monoester Hydrolases, VHR, vaccinia H1-related phosphatase, High-Throughput Screening Assays, Liver Regeneration, Virtual screening methods, HEK293 Cells, Docking (molecular)

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f46de50a9d8d6d3d65e673435e70c934Test

المؤلفون: Jiwen Wang, Fang Ding, Xinxin Li, Haohan Wang, Wenqiang Sun, Lingli Sun, Chunchun Han, Hehe Liu

المصدر: Bioscience Reports
Bioscience Reports, Vol 34, Iss 5, p e00143 (2014)

مصطلحات موضوعية: Myoblast proliferation, Follistatin, duck, IGF, insulin-like growth factor, lcsh:Life, lcsh:QR1-502, Biochemistry, mTORC2, lcsh:Microbiology, HRP, horseradish peroxidise, chemistry.chemical_compound, Phosphatidylinositol 3-Kinases, MTT, 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide, LY294002, Cells, Cultured, TOR Serine-Threonine Kinases, myoblasts, Cell biology, FST, Follistatin, Ducks, PI3K, phosphoinositide 3-kinase, Myoblasts, Skeletal, proliferation, Biophysics, P70-S6 Kinase 1, mTOR, mammalian target of rapamycin, Biology, Avian Proteins, MuRF1, muscle RING finger-1, Animals, MSTN, myostatin, Molecular Biology, Protein kinase B, PI3K/AKT/mTOR pathway, Cell Proliferation, Original Paper, S6K, S6 kinase, RPTOR, BrdU, 5-bromo-2V-deoxyuridine, Cell Biology, Molecular biology, lcsh:QH501-531, PI3K/Akt/mTOR signalling, chemistry, Akt, protein kinase B, biology.protein, IGF-IR, type 1 insulin-like growth factor receptor, human activities, Proto-Oncogene Proteins c-akt, DAPI, 4′,6-diamidino-2-phenylindole

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2320703b310afb5521353123b95740e3Test
https://pubmed.ncbi.nlm.nih.gov/25200144Test

المؤلفون: Yanzhi Xia, Shimin Wu, Xiong Wei, Ximing Wang, Ling Hong, Bo Wang

المصدر: Cell Biology International Reports

مصطلحات موضوعية: MAPK/ERK pathway, SREBP, sterol response element binding protein, MTT, 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide, Downregulation and upregulation, TCC, transitional cell carcinoma, medicine, MC, mock control, SCCD, Schnyder crystalline corneal dystrophy, Telomerase reverse transcriptase, GAPDH, human glyceraldehyde 3-phosphate dehydrogenase, Oligonucleotide, Cell growth, Chemistry, MEK inhibitor, Cell Biology, Transfection, medicine.disease, MAPK, Cell biology, NC, negative group, cell proliferation, siRNA, small interfering RNA, Immunology, embryonic structures, Schnyder crystalline corneal dystrophy, TERE1/UBIAD1, hTERT, IHC, immunohistochemistry, MAPK, mitogen-activated protein kinase, Research Article

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e30b224bc06cb16befe2431b1b29cc3cTest
http://europepmc.org/articles/PMC3475436Test