نتائج البحث - "MTOR Inhibitors"

71

Design, synthesis, and biological evaluation of imidazo[1,2- b ]pyridazine derivatives as mTOR inhibitors

المؤلفون: Liangren Zhang, Beibei Mao, Lihe Zhang, Shanyun Gao, Yiran Weng

المصدر: European Journal of Medicinal Chemistry. 129:135-150

مصطلحات موضوعية: 0301 basic medicine, Lung Neoplasms, Cell cycle checkpoint, Mice, Nude, Antineoplastic Agents, Pharmacology, Inhibitory postsynaptic potential, Pyridazine, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Cell Line, Tumor, Drug Discovery, Animals, Humans, Protein Kinase Inhibitors, Protein kinase B, PI3K/AKT/mTOR pathway, Cell Proliferation, TOR Serine-Threonine Kinases, Organic Chemistry, General Medicine, Discovery and development of mTOR inhibitors, Pyridazines, 030104 developmental biology, chemistry, Biochemistry, A549 Cells, Cell culture, Drug Design, 030220 oncology & carcinogenesis, Heterografts, Phosphorylation, Drug Screening Assays, Antitumor

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e41e281dbe0f00615b627af154c2e98cTest
https://doi.org/10.1016/j.ejmech.2017.02.015Test

72

In pursuit of synergy: An investigation of the PI3K/mTOR/MEK co-targeted inhibition strategy in NSCLC

المؤلفون: N. Leonard, Siobhan Nicholson, Sinead Cuffe, Stephen P. Finn, Kathy Gately, Ronan Ryan, Martin P. Barr, Susan Heavey, Niall McVeigh, Kenneth J. O'Byrne, Vincent Young

المصدر: Oncotarget

مصطلحات موضوعية: Male, 0301 basic medicine, Oncology, Veterinary medicine, Lung Neoplasms, DNA Mutational Analysis, Apoptosis, NSCLC, PI3K, 0302 clinical medicine, Piperidines, Carcinoma, Non-Small-Cell Lung, Clinical investigation, Antineoplastic Combined Chemotherapy Protocols, Medicine, Molecular Targeted Therapy, Sulfonamides, TOR Serine-Threonine Kinases, MEK inhibitor, High mortality, Drug Synergism, co-target, Middle Aged, MAP Kinase Kinase Kinases, Discovery and development of mTOR inhibitors, MEK, Gene Expression Regulation, Neoplastic, 030220 oncology & carcinogenesis, Female, Research Paper, Signal Transduction, medicine.medical_specialty, Indazoles, Class I Phosphatidylinositol 3-Kinases, Translational research, Gene Expression Regulation, Enzymologic, lung, 03 medical and health sciences, Internal medicine, Humans, Protein Kinase Inhibitors, PI3K/AKT/mTOR pathway, Aged, Cell Proliferation, Dose-Response Relationship, Drug, business.industry, Cancer, medicine.disease, respiratory tract diseases, Clinical trial, 030104 developmental biology, A549 Cells, Mutation, Azetidines, business

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce4a84adaa2966ee301712af6eea68d5Test
https://doi.org/10.18632/oncotarget.12755Test

73

CXCR4/CXCL12/CXCR7 axis is functional in neuroendocrine tumors and signals on mTOR

المؤلفون: G. Botti, Luciano Pezzullo, Salvatore Tafuto, Nunzia Simona Losito, Marialaura Del Basso De Caro, Fabiana Tatangelo, Concetta Sciammarella, Gennaro Ciliberto, Valeria Ramundo, Elia Guadagno, Caterina Ieranò, Crescenzo D'Alterio, Annamaria Colao, Antongiulio Faggiano, Stefania Scala, Luisa Circelli, Francesco Izzo, Massimo Aria

المساهمون: Circelli, Luisa, Sciammarella, Concetta, Guadagno, Elia, Tafuto, Salvatore, DEL BASSO DE CARO, Marialaura, Botti, Giovanni, Pezzullo, Luciano, Aria, Massimo, Ramundo, Valeria, Tatangelo, Fabiana, Simona Losito, Nunzia, Ieranò, Caterina, D'Alterio, Crescenzo, Izzo, Francesco, Ciliberto, Gennaro, Colao, Annamaria, Faggiano, Antongiulio, Scala, Stefania

المصدر: ResearcherID
Oncotarget

مصطلحات موضوعية: Adult, Male, 0301 basic medicine, Receptors, CXCR4, medicine.medical_specialty, Prognostic factor, Poor prognosis, clinical outcome, Neuroendocrine tumors, 03 medical and health sciences, 0302 clinical medicine, Cell Line, Tumor, Tumor stage, Humans, Medicine, PI3K/AKT/mTOR pathway, Aged, Cell Proliferation, Aged, 80 and over, Receptors, CXCR, Gynecology, business.industry, TOR Serine-Threonine Kinases, chemokine, grading, Middle Aged, medicine.disease, Discovery and development of mTOR inhibitors, Immunohistochemistry, Chemokine CXCL12, NET, mTOR, MCF-7 Cells, Neuroendocrine Tumors, Signal Transduction, 030104 developmental biology, Oncology, 030220 oncology & carcinogenesis, Ki67 index, Parathyroid surgery, business, Research Paper