المؤلفون: Michela Campolo, Alessio Ardizzone, Marika Lanza, Marika Cordaro, Sarah Adriana Scuderi, Emanuela Esposito, Giovanna Casili, Salvatore Cuzzocrea, Alessia Filippone, Irene Paterniti

المصدر: Journal of Cellular and Molecular Medicine

مصطلحات موضوعية: Male, apoptosis, astrogliosis, behavioural performance, KU0063794, mTOR, mTORC1, mTORC2, neuroinflammation, neuronal death, rapamycin, traumatic brain injury, Necrosis, Traumatic brain injury, Morpholines, Pharmacology, Lesion, Mice, Brain Injuries, Traumatic, Medicine, Animals, Enzyme Inhibitors, Neuroinflammation, PI3K/AKT/mTOR pathway, Cell Proliferation, Neurons, Sirolimus, Cell Death, business.industry, TOR Serine-Threonine Kinases, Cell Biology, Original Articles, MTOR Inhibitors, medicine.disease, nervous system diseases, Astrogliosis, Disease Models, Animal, Pyrimidines, nervous system, Neuroinflammatory Diseases, Molecular Medicine, Original Article, medicine.symptom, business, Immunosuppressive Agents, Signal Transduction

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed1e7c71b99995cf2489cffa15aef7feTest
http://hdl.handle.net/11570/3208354Test

المؤلفون: Hoff, Uwe, Markmann, Denise, Nieminen-Kelhä, Melina, Budde, Klemens, Hegner, Björn

المصدر: Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
Scientific Reports

مصطلحات موضوعية: Male, Vascular Endothelial Growth Factor A, mTOR inhibitors, Science, Gene Expression, kidney transplantation, Article, Kidney Tubules, Proximal, Animals, Regeneration, Cell Proliferation, Sirolimus, Dose-Response Relationship, Drug, urogenital system, Rats, Inbred F344, Acute kidney injury, rats, Nephrology, Rats, Inbred Lew, Reperfusion Injury, Medicine, Negative Results, 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ae4b72f67628a7bee0cf7f3b09a86edTest
https://refubium.fu-berlin.de/handle/fub188/38221Test

المؤلفون: Skarphedinn Halldorsson, Maria Tunset Grinde, Ottar Rolfsson, Qiong Wang, Sigurdur Trausti Karvelsson, Kotryna Seip, Gunhild Marie Maelandsmo, Freyr Jóhannsson, Siver Andreas Moestue, Arnar Sigurdsson

المصدر: Molecular Cancer Research

مصطلحات موضوعية: Cancer Research, Epithelial-Mesenchymal Transition, Glutamine, Apoptosis, Breast Neoplasms, Pentose Phosphate Pathway, chemistry.chemical_compound, Lipid biosynthesis, medicine, Tumor Cells, Cultured, Humans, Glycolysis, Molecular Biology, PI3K/AKT/mTOR pathway, Cell Proliferation, Chemistry, Cell Cycle, Cancer, Lipid metabolism, Mesenchymal Stem Cells, Glutathione, MTOR Inhibitors, medicine.disease, Oncology, Cell culture, Drug Resistance, Neoplasm, Cancer research, Metabolome, Female

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::30918c45617bf8e18e4b058da4d64403Test
https://pubmed.ncbi.nlm.nih.gov/34088869Test

المؤلفون: Roberto Ballarino, Toyoaki Natsume, Laura Baranello, Rashid Mehmood, Radosław Grochowski, Anika Wiegard, Jan Grosser, Michele Ceribelli, Donald P. Cameron, Anna H. Bizard, Fedor Kouzine, Nicola Crosetto, Vladislav Kuzin, Arne Lindqvist, Ivana Karabogdan, Francesco Valant

المصدر: Wiegard, A, Kuzin, V, Cameron, D P, Grosser, J, Ceribelli, M, Mehmood, R, Ballarino, R, Valant, F, Grochowski, R, Karabogdan, I, Crosetto, N, Lindqvist, A, Bizard, A H, Kouzine, F, Natsume, T & Baranello, L 2021, ' Topoisomerase 1 activity during mitotic transcription favors the transition from mitosis to G1 ', Molecular Cell, vol. 81, no. 24, pp. 5007-5024.e9 . https://doi.org/10.1016/j.molcel.2021.10.015Test

مصطلحات موضوعية: Transcription, Genetic, Mitosis, RNA polymerase II, Biology, Chromosome segregation, Transcription (biology), Humans, supercoiling, Prometaphase, TOP1, Molecular Biology, Cell Proliferation, mitosis, topoisomerase, G1 Phase, Promoter, MTOR Inhibitors, Cell Biology, Chromatin Assembly and Disassembly, HCT116 Cells, segregation, Chromatin, Cell biology, Gene Expression Regulation, Neoplastic, ChIP-seq, polymerase, DNA Topoisomerases, Type I, biology.protein, Chromatin Immunoprecipitation Sequencing, DNA supercoil, cell cycle, RNA Polymerase II, RNAPII, Colorectal Neoplasms, transcription

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b2285bb0b44adcf14340fca481f1e79Test
https://doi.org/10.1016/j.molcel.2021.10.015Test

المؤلفون: Marc R. Mansour, Alla Berezovskaya, E. Elizabeth Patton, Chang-Bin Jing, Julia Etchin, Charles K. Kaufman, Mark W. Zimmerman, Scott J. Rodig, Megan W. Martel, A. Thomas Look, Leonard I. Zon, Hillary M. Layden, Grace Thurston, Shuning He, Ellen van Rooijen

المصدر: Oncogene
He, S, Zimmerman, M W, Layden, H M, Berezovskaya, A, Etchin, J, Martel, M W, Thurston, G, Jing, C-B, van Rooijen, E, Kaufman, C K, Rodig, S J, Zon, L I, Patton, E E, Mansour, M R & Look, A T 2021, ' Synergistic melanoma cell death mediated by inhibition of both MCL1 and BCL2 in high-risk tumors driven by NF1/PTEN loss ', Oncogene . https://doi.org/10.1038/s41388-021-01926-yTest

مصطلحات موضوعية: 0301 basic medicine, Cancer Research, Programmed cell death, Cell Survival, Thiophenes, Biology, Article, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Loss of Function Mutation, Cell Line, Tumor, Genetics, medicine, PTEN, Animals, Humans, Everolimus, Cancer models, Molecular Biology, neoplasms, Melanoma, PI3K/AKT/mTOR pathway, Zebrafish, Cell Proliferation, Sirolimus, Sulfonamides, Neurofibromin 1, Venetoclax, PTEN Phosphohydrolase, Drug Synergism, MTOR Inhibitors, medicine.disease, Bridged Bicyclo Compounds, Heterocyclic, Xenograft Model Antitumor Assays, Temsirolimus, 030104 developmental biology, Pyrimidines, chemistry, Proto-Oncogene Proteins c-bcl-2, 030220 oncology & carcinogenesis, Cancer research, biology.protein, Myeloid Cell Leukemia Sequence 1 Protein, medicine.drug

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9204b7f93b2e55dccf004f4c12d0f189Test
https://pubmed.ncbi.nlm.nih.gov/34331013Test

المؤلفون: Ana María Hurtado, Satu Mustjoki, Urpu Salmenniemi, Jani Huuhtanen, Pekka Ellonen, Rajiv K. Khajuria, Mikko Myllymäki, Matti Kankainen, Daehong Kim, Sofie Lundgren, Mikko A. I. Keränen, Giljun Park, Maija Itälä-Remes, Tzu Hua Chen-Liang, Andres Jerez, Samuli Eldfors, Laura Cardeñoso, Sari Hannula, Oscar Brück, Anna Kreutzman, Valle Gómez García de Soria, Tapio Lönnberg, Cecilia Muñoz-Calleja

المساهمون: Department of Clinical Chemistry and Hematology, Hematologian yksikkö, HUS Comprehensive Cancer Center, Department of Oncology, TRIMM - Translational Immunology Research Program, HUSLAB, University of Helsinki, Research Programs Unit, Institute for Molecular Medicine Finland, Department of Medical and Clinical Genetics, Helsinki University Hospital Area, Digital Precision Cancer Medicine (iCAN), Division of Pharmaceutical Biosciences, UAM. Departamento de Medicina, Instituto de Investigación Sanitaria Hospital Universitario de La Princesa (IIS-IP)

المصدر: Biblos-e Archivo: Repositorio Institucional de la UAM
Universidad Autónoma de Madrid
Nature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
Nature Communications
Biblos-e Archivo. Repositorio Institucional de la UAM
instname

مصطلحات موضوعية: 0301 basic medicine, Resistance to mTOR inhibitors, Somatic cell, T-Lymphocytes, medicine.medical_treatment, NF-KAPPA-B, Graft vs Host Disease, General Physics and Astronomy, Apoptosis, Hematopoietic stem cell transplantation, medicine.disease_cause, Graft-versus-host disease, mTORC2, ACTIVATION, Pathogenesis, 0302 clinical medicine, immune system diseases, hemic and lymphatic diseases, lcsh:Science, Immunity, Cellular, Mutation, Multidisciplinary, TOR Serine-Threonine Kinases, CANCER, Cellular immunity, 3. Good health, surgical procedures, operative, medicine.anatomical_structure, 030220 oncology & carcinogenesis, Haematological diseases, Mutations, Protein Binding, EXPRESSION, Medicina, Science, T cell, Blotting, Western, 3122 Cancers, T cells, BIOLOGY, Article, General Biochemistry, Genetics and Molecular Biology, REPERTOIRE, 03 medical and health sciences, medicine, Humans, Immunoprecipitation, STAT3 MUTATIONS, PI3K/AKT/mTOR pathway, Cell Proliferation, business.industry, STEM-CELL TRANSPLANTATION, General Chemistry, medicine.disease, HEK293 Cells, 030104 developmental biology, DISCOVERY, Alteration and activation, Cancer research, Hematopoietic stem cell transplantation (HSCT), lcsh:Q, business, CD4(+)

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80004dc6bc4cf39c734b43d69bf77021Test
https://doi.org/10.1038/s41467-020-16115-wTest

المؤلفون: Chang, Ming‐Yang, Ong, Albert C. M.

المصدر: British Journal of Clinical Pharmacology; Oct2013, Vol. 76 Issue 4, p524-535, 12p

مصطلحات موضوعية: POLYCYSTIC kidney disease, CREB protein, MTOR inhibitors, THERAPEUTICS, VASOPRESSIN, CELL proliferation

المؤلفون: Anna Jucglà, R.M. Penín, Agnès Figueras, Francesc Viñals, Antoni Riera-Mestre, Pau Cerdà, Jose Maria Mora, Adriana Iriarte

المساهمون: Universitat de Barcelona

المصدر: Cells
Volume 8
Issue 9
Recercat. Dipósit de la Recerca de Catalunya
instname
Dipòsit Digital de la UB
Universidad de Barcelona
Cells, Vol 8, Iss 9, p 971 (2019)

مصطلحات موضوعية: Male, Pathology, phosphatidylinositol 3-kinase, Proliferation index, Activin Receptors, Type II, Biopsy, Cell Cycle Proteins, chemistry.chemical_compound, Medicine, Phosphorylation, Telangiectasia, lcsh:QH301-705.5, medicine.diagnostic_test, Kinase, Endoglin, Intracellular Signaling Peptides and Proteins, rare diseases, General Medicine, Hemorràgia, Middle Aged, Rare diseases, Endothelial stem cell, Female, Telangiectasia, Hereditary Hemorrhagic, medicine.symptom, Malalties rares, transforming growth factor-beta (TGF-β), Growth factors, Signal Transduction, Adult, medicine.medical_specialty, congenital, hereditary, and neonatal diseases and abnormalities, mTOR inhibitors, Hemorrhage, hemorrhagic hereditary telangiectasia, Article, Factors de creixement, Humans, Phosphatidylinositol, telangiectasia, PI3K/AKT/mTOR pathway, Aged, Cell Proliferation, Epidermis (botany), Smad pathway, business.industry, Ribosomal Protein S6 Kinases, Endothelial Cells, chemistry, lcsh:Biology (General), Case-Control Studies, Mutation, business, Proto-Oncogene Proteins c-akt

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77eb8106df5884d7d1a1970e14f4ff90Test

المؤلفون: Mingkang Zhou, Wei Wei, Xiao He, Ma Xiaodong, Chengjun Peng, Mingming Zhang, Heng Zhang

المصدر: Bioorganic & Medicinal Chemistry Letters. 49:128286

مصطلحات موضوعية: Clinical Biochemistry, Pharmaceutical Science, Biochemistry, Histone Deacetylases, Pyrazolopyrimidine, chemistry.chemical_compound, Cell Line, Tumor, Drug Discovery, Humans, Molecular Biology, PI3K/AKT/mTOR pathway, Cell Proliferation, Kinase, TOR Serine-Threonine Kinases, Organic Chemistry, MTOR Inhibitors, HDAC1, In vitro, Histone Deacetylase Inhibitors, Molecular Docking Simulation, Pyrimidines, chemistry, Cell culture, Cancer research, Pyrazoles, Molecular Medicine, Pharmacophore, Intracellular, Protein Binding

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d77fa8b58e8defb945779ab983a740e2Test
https://doi.org/10.1016/j.bmcl.2021.128286Test

المؤلفون: Kuan-Wei Lee, Max K. Leong, Ching-Feng Weng, Varadharajan Thiyagarajan

المصدر: Journal of Biomolecular Structure and Dynamics. 36:4220-4234

مصطلحات موضوعية: Male, 0301 basic medicine, Curcumin, Cell Survival, In silico, Biology, Rats, Sprague-Dawley, Serine, 03 medical and health sciences, 0302 clinical medicine, Structural Biology, Hepatic Stellate Cells, Animals, Phosphorylation, Threonine, Protein Kinase Inhibitors, Molecular Biology, Cells, Cultured, PI3K/AKT/mTOR pathway, Cell Proliferation, Sirolimus, Dose-Response Relationship, Drug, Kinase, Cell growth, TOR Serine-Threonine Kinases, Ribosomal Protein S6 Kinases, 70-kDa, General Medicine, Discovery and development of mTOR inhibitors, Cell biology, Molecular Docking Simulation, 030104 developmental biology, 030220 oncology & carcinogenesis, Hepatic stellate cell

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb0d95f4ed856b4dbefe3bd369c0c9acTest
https://doi.org/10.1080/07391102.2017.1411295Test