التفاصيل البيبلوغرافية
| العنوان: |
Endothelial miR-196b-5p regulates angiogenesis via the hypoxia/miR-196b-5p/HMGA2/HIF1α loop. |
| المؤلفون: |
Ruizhe Ren1,2, Kefan Ma1,2, Yuanqing Jiang1,2, Junbo Chen1,2, Yaohui Kou1,2, Zhen Ge3, Zhaoming Chen4, Xiyang Wei4 xiyangw@zju.edu.cn, Luyang Yu1,2 luyangyu@zju.edu.cn |
| المصدر: |
American Journal of Physiology: Cell Physiology. Feb2023, Vol. 324 Issue 2, pC407-C419. 13p. |
| مصطلحات موضوعية: |
*NEOVASCULARIZATION, *ENDOTHELIAL cells, *CELL physiology |
| مستخلص: |
Angiogenesis is involved in development, reproduction, wound healing, homeostasis, and other pathophysiological events. Imbalanced angiogenesis predisposes patients to various pathological processes, such as angiocardiopathy, inflammation, and tumorigenesis. MicroRNAs (miRNAs) have been found to be important in regulating cellular processing and physiological events including angiogenesis. However, the role of miRNAs that regulate angiogenesis (angiomiRs) is not fully understood. Here, we observed a downregulation of the miR-196 family in endothelial cells upon hypoxia. Functionally, miR-196b-5p inhibited the angiogenic functions of endothelial cells in vitro and suppressed angiogenesis in Matrigel plugs and skin wound healing in vivo. Mechanistically, miR-196b-5p bound onto the 3' untranslated region (UTR) of high-mobility group AT-hook 2 (HMGA2) mRNA and repressed the translation of HMGA2, which in turn represses HIF1α accumulation in endothelial cells upon hypoxia. Together, our results establish the role of endothelial miR-196b-5p as an angiomiR that negatively regulates endothelial growth in angiogenesis via the hypoxia/miR-196b-5p/HMGA2/HIF1α loop. miR-196b-5p and its regulatory loop could be an important addition to the molecular mechanisms underlying angiogenesis and may serve as potential targets for antiangiogenic therapy. [ABSTRACT FROM AUTHOR] |
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