دورية أكاديمية
Lymphocyte predominant cells detect Moraxella catarrhalis-derived antigens in nodular lymphocyte-predominant Hodgkin lymphoma.
| العنوان: | Lymphocyte predominant cells detect Moraxella catarrhalis-derived antigens in nodular lymphocyte-predominant Hodgkin lymphoma. |
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| المؤلفون: | Thurner, L., Hartmann, S., Fadle, N., Regitz, E., Kemele, M., Kim, Y.J., Bohle, R.M., Nimmesgern, A., von Müller, L., Kempf, VAJ, Weniger, M.A., Neumann, F., Schneider, N., Vornanen, M., Sundström, C., de Leval, L., Engert, A., Eichenauer, D.A., Küppers, R., Preuss, K.D., Hansmann, M.L., Pfreundschuh, M. |
| المصدر: | Nature communications, vol. 11, no. 1, pp. 2465 |
| سنة النشر: | 2020 |
| المجموعة: | Université de Lausanne (UNIL): Serval - Serveur académique lausannois |
| مصطلحات موضوعية: | Adolescent, Adult, Aged, Antigens, Bacterial/immunology, Autoantigens/immunology, B-Lymphocytes/immunology, Cell Line, Tumor, Cell Proliferation, Child, DNA-Directed RNA Polymerases/metabolism, Histocompatibility Antigens Class II/metabolism, Hodgkin Disease/blood, Hodgkin Disease/immunology, Hodgkin Disease/microbiology, Humans, Immunoglobulin D/metabolism, Immunoglobulin Fab Fragments/immunology, Immunoglobulin Variable Region/genetics, Male, Middle Aged, Models, Biological, Moraxella catarrhalis/immunology, Receptors, Antigen, B-Cell/metabolism |
| الوصف: | Nodular lymphocyte-predominant Hodgkin lymphoma (NLPHL) is a rare lymphoma of B-cell origin with frequent expression of functional B-cell receptors (BCRs). Here we report that expression cloning followed by antigen screening identifies DNA-directed RNA polymerase beta' (RpoC) from Moraxella catarrhalis as frequent antigen of BCRs of IgD + LP cells. Patients show predominance of HLA-DRB1*04/07 and the IgVH genes encode extraordinarily long CDR3s. High-titer, light-chain-restricted anti-RpoC IgG1/κ-type serum-antibodies are additionally found in these patients. RpoC and MID/hag, a superantigen co-expressed by Moraxella catarrhalis that is known to activate IgD + B cells by binding to the Fc domain of IgD, have additive activation effects on the BCR, the NF-κB pathway and the proliferation of IgD + DEV cells expressing RpoC-specific BCRs. This suggests an additive antigenic and superantigenic stimulation of B cells with RpoC-specific IgD + BCRs under conditions of a permissive MHC-II haplotype as a model of NLPHL lymphomagenesis, implying future treatment strategies. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 2041-1723 |
| العلاقة: | info:eu-repo/semantics/altIdentifier/pmid/32424289; info:eu-repo/semantics/altIdentifier/eissn/2041-1723; info:eu-repo/semantics/altIdentifier/urn/urn:nbn:ch:serval-BIB_77EFC721B4FE9; https://serval.unil.ch/notice/serval:BIB_77EFC721B4FETest; urn:issn:2041-1723; https://serval.unil.ch/resource/serval:BIB_77EFC721B4FE.P001/REF.pdfTest; http://nbn-resolving.org/urn/resolver.pl?urn=urn:nbn:ch:serval-BIB_77EFC721B4FE9Test |
| DOI: | 10.1038/s41467-020-16375-6 |
| الإتاحة: | https://doi.org/10.1038/s41467-020-16375-6Test https://serval.unil.ch/notice/serval:BIB_77EFC721B4FETest https://serval.unil.ch/resource/serval:BIB_77EFC721B4FE.P001/REF.pdfTest http://nbn-resolving.org/urn/resolver.pl?urn=urn:nbn:ch:serval-BIB_77EFC721B4FE9Test |
| حقوق: | info:eu-repo/semantics/openAccess ; CC BY 4.0 ; https://creativecommons.org/licenses/by/4.0Test/ |
| رقم الانضمام: | edsbas.98B50E6B |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 20411723 |
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| DOI: | 10.1038/s41467-020-16375-6 |