نتائج البحث - "Activation-induced (cytidine) deaminase"

1

Splicing regulator SRSF1-3 that controls somatic hypermutation of IgV genes interacts with topoisomerase 1 and AID

المؤلفون: Anshu Agarwal, Ankit Jaiswal, Amit Kumar Singh, Anubhav Tamrakar, Prashant Kodgire, Prabhanshu Tripathi, Naoki Kanayama

المصدر: Molecular Immunology. 116:63-72

مصطلحات موضوعية: 0301 basic medicine, RNA Splicing, In silico, Immunology, Regulator, Somatic hypermutation, Proximity ligation assay, Cell Line, Mice, 03 medical and health sciences, 0302 clinical medicine, Cytidine Deaminase, Activation-induced (cytidine) deaminase, Animals, Immunoprecipitation, Protein Isoforms, Amino Acid Sequence, Molecular Biology, Cell Nucleus, B-Lymphocytes, Genes, Immunoglobulin, Serine-Arginine Splicing Factors, biology, Cytidine deaminase, Immunoglobulin Class Switching, Cell biology, 030104 developmental biology, DNA Topoisomerases, Type I, RNA splicing, biology.protein, Somatic Hypermutation, Immunoglobulin, Chickens, Nuclear localization sequence, 030215 immunology

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::633df14e91cff02b4d68f15dfaf3173aTest
https://doi.org/10.1016/j.molimm.2019.10.002Test

2

CUL7 E3 Ubiquitin Ligase Mediates the Degradation of Activation-Induced Cytidine Deaminase and Regulates the Ig Class Switch Recombination in B Lymphocytes

المؤلفون: Yang Liu, Liyang Wu, Xiancai Ma, Xu Zhang, Yiwen Zhang, Junsong Zhang, Gen Lu, Feng Huang, Haihua Luo, Yuewen Luo, Yanyan Yang, Yixin Zeng, Xiaoping Tang, Hui Zhang, Linghua Li, Qin Liu, Ting Pan

المصدر: The Journal of Immunology. 203:269-281

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::408e37f8d1c561b09509507a537e4984Test
https://doi.org/10.4049/jimmunol.1900125Test

3

Activation‐Induced Cytidine Deaminase Regulates Fibroblast Growth Factor/Extracellular Signal‐Regulated Kinases Signaling to Achieve the Naïve Pluripotent State During Reprogramming

المؤلفون: Ritu Kumar, Todd Evans

المصدر: Stem Cells (Dayton, Ohio)

مصطلحات موضوعية: 0301 basic medicine, MAPK/ERK pathway, Somatic cell, MAP Kinase Signaling System, Induced Pluripotent Stem Cells, iPSCs, Fibroblast growth factor, Embryonic Stem Cells/Induced Pluripotent Stem Cells, Cell Line, 03 medical and health sciences, Mice, 0302 clinical medicine, Cytidine Deaminase, Activation-induced (cytidine) deaminase, Animals, Cellular Reprogramming Techniques, Induced pluripotent stem cell, Extracellular Signal-Regulated MAP Kinases, Mitogen‐activated protein kinase signaling, DNA methylation, biology, Cell Biology, Cytidine deaminase, Cellular Reprogramming, Cell biology, Fibroblast Growth Factors, 030104 developmental biology, biology.protein, Molecular Medicine, Epigenetics, Stem cell, Reprogramming, 030217 neurology & neurosurgery, Developmental Biology

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc5fb9572ffcdce4e1b5c6a86a4c7986Test
http://europepmc.org/articles/PMC6766926Test

4

Transient AID expression for in situ mutagenesis with improved cellular fitness

المؤلفون: Talal Salem Al-Qaisi, Steve R. Roffler, Yu-Cheng Su

المصدر: Scientific Reports, Vol 8, Iss 1, Pp 1-10 (2018)
Scientific Reports

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5cbbfa41cdc66476822006d1e339201eTest
http://link.springer.com/article/10.1038/s41598-018-27717-2Test

5

A Bayesian model based computational analysis of the relationship between bisulfite accessible single-stranded DNA in chromatin and somatic hypermutation of immunoglobulin genes

المؤلفون: Thomas MacCarthy, Haipeng Xing, Zhi Duan, Guojun Yu, Catherine Tang, Matthew D. Scharff, Yingru Wu

المصدر: PLoS Computational Biology, Vol 17, Iss 9, p e1009323 (2021)
PLoS Computational Biology

مصطلحات موضوعية: B Cells, Gene Expression, Biochemistry, Genome, White Blood Cells, chemistry.chemical_compound, Animal Cells, Medicine and Health Sciences, Morphogenesis, Activation-induced (cytidine) deaminase, Biology (General), Genes, Immunoglobulin, Ecology, biology, Chromosome Biology, Nucleotides, Genomics, Chromatin, Nucleic acids, Bisulfite, Computational Theory and Mathematics, Modeling and Simulation, Epigenetics, Cellular Types, Research Article, QH301-705.5, Base pair, Immune Cells, Immunology, DNA transcription, DNA, Single-Stranded, Somatic hypermutation, Computational biology, Cell Line, Cellular and Molecular Neuroscience, Genetics, Humans, Sulfites, Antibody-Producing Cells, Molecular Biology, Gene, Ecology, Evolution, Behavior and Systematics, Blood Cells, Biology and Life Sciences, DNA structure, Computational Biology, Bayes Theorem, Cell Biology, DNA, Morphogenic Segmentation, G-Quadruplexes, Macromolecular structure analysis, chemistry, Mutation, biology.protein, Developmental Biology

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dfa4c0f19a0f3b92662e54b573ab94cfTest
https://doi.org/10.1371/journal.pcbi.1009323Test

6

Depletion of recombination-specific cofactors by the C-terminal mutant of the activation-induced cytidine deaminase causes the dominant negative effect on class switch recombination

المؤلفون: Nasim A. Begum, Afzal Husain, Maki Kobayashi, Tasuku Honjo, Azza Al Ismail

المصدر: International Immunology. 29:525-537

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::754fff39e491cd7912fe99524be6cf26Test
https://doi.org/10.1093/intimm/dxx061Test

7

SAMHD1-mediated dNTP degradation is required for efficient DNA repair during antibody class switch recombination

المؤلفون: Tasuku Honjo, Jiangliang Xu, Ji‐Yang Wang, Hodaka Fujii, Maki Kobayashi, Afzal Husain, Jan Rehwinkel, Mikiyo Nakata, Nasim A. Begum

المصدر: EMBO J

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29b65ba0ce23274de24ee5221f05774aTest
https://pubmed.ncbi.nlm.nih.gov/32511795Test

8

Control of Toll-like Receptor-mediated T Cell-independent Type 1 Antibody Responses by the Inducible Nuclear Protein IκB-ζ

المؤلفون: Takayuki Isagawa, Fumito Hanihara-Tatsuzawa, Hanae Miura, Ichiro Manabe, Takashi Maruyama, Shuhei Kobayashi, Atsushi Okuma

المصدر: The Journal of Biological Chemistry

مصطلحات موضوعية: Lipopolysaccharides, Transcription Factor, T-Lymphocytes, Cellular differentiation, T cell, Immunology, B-cell receptor, Receptors, Antigen, B-Cell, Biology, Biochemistry, Cell Line, Histones, Recombinases, Mice, Activation-induced Cytidine Deaminase (AID), Cytidine Deaminase, Plasma cell differentiation, medicine, Animals, CD40 Antigens, Molecular Biology, Alleles, B cell, Adaptor Proteins, Signal Transducing, Cell Proliferation, Recombination, Genetic, B-Lymphocytes, Toll-like receptor, Toll-Like Receptors, Nuclear Proteins, Cell Differentiation, Cell Biology, Cytidine deaminase, Immunoglobulin Class Switching, Molecular biology, IκB-z, medicine.anatomical_structure, Gene Expression Regulation, B Cell, Immunoglobulin class switching, Antibody Formation, Cellular Immune Response, Toll-like Receptor (TLR), Spleen, Signal Transduction

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d97a733cf09c6d86630d9e7a1bd4cabbTest
https://doi.org/10.1074/jbc.m114.553230Test

9

Excision of Uracil from Transcribed DNA Negatively Affects Gene Expression

المؤلفون: Bork Lühnsdorf, Andriy Khobta, Bernd Epe

المصدر: Journal of Biological Chemistry. 289:22008-22018

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d2b01e2943bff6cbae7c279dffd25e4Test
https://doi.org/10.1074/jbc.m113.521807Test

10

Up-regulation of activation-induced cytidine deaminase causes genetic aberrations at the CDKN2b-CDKN2a in gastric cancer

المؤلفون: Yoko Niwa, Tsutomu Chiba, Hiroyuki Marusawa, Yuko Matsumoto, Kazuo Kinoshita, Yoshiharu Sakai

المصدر: Gastroenterology. 139(6):1984-1994

مصطلحات موضوعية: Gene Dosage, Genetic Alterations, Mice, Transgenic, Gene mutation, medicine.disease_cause, Gene Expression Regulation, Enzymologic, Malignant transformation, Cell Line, Helicobacter Infections, Mice, CDKN2A, Stomach Neoplasms, Cytidine Deaminase, Activation-induced (cytidine) deaminase, medicine, Gastric mucosa, Animals, Humans, Cyclin-Dependent Kinase Inhibitor p16, Cyclin-Dependent Kinase Inhibitor p15, Chromosome Aberrations, Hepatology, biology, Helicobacter pylori, Stomach, Gastroenterology, Epithelial Cells, Cytidine deaminase, Activation-Induced Cytidine Deaminase, biology.organism_classification, Molecular biology, digestive system diseases, Up-Regulation, Gene Expression Regulation, Neoplastic, Mice, Inbred C57BL, Gastric Cancer, medicine.anatomical_structure, Cell Transformation, Neoplastic, Tumor-Related Genes, biology.protein, Cancer research, Carcinogenesis

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d83556c2d4e7a4114cbae6f744eb83dcTest
http://hdl.handle.net/2433/134556Test

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