دورية أكاديمية
A family of insulin-like growth factor II mRNA-binding proteins represses translation in late development
| العنوان: | A family of insulin-like growth factor II mRNA-binding proteins represses translation in late development |
|---|---|
| المؤلفون: | Nielsen, J, Christiansen, J, Lykke-Andersen, J, Johnsen, A H, Wewer, Ulla M., Nielsen, F C |
| المصدر: | Nielsen , J , Christiansen , J , Lykke-Andersen , J , Johnsen , A H , Wewer , U M & Nielsen , F C 1999 , ' A family of insulin-like growth factor II mRNA-binding proteins represses translation in late development ' , Molecular and Cellular Biology , vol. 19 , no. 2 , pp. 1262-1270 . < http://mcb.asm.org/cgi/content/abstract/19/2/1262Test > |
| سنة النشر: | 1999 |
| المجموعة: | University of Copenhagen: Research / Forskning ved Københavns Universitet |
| مصطلحات موضوعية: | 3T3 Cells, Amino Acid Sequence, Animals, Binding Sites, Cell Line, Chickens, Cloning, Molecular, DNA, Complementary, Embryonic and Fetal Development, Gene Expression Regulation, Developmental, Humans, Insulin-Like Growth Factor II, Mice, Molecular Sequence Data, Protein Biosynthesis, RNA, Messenger, RNA-Binding Proteins, Sequence Homology, Amino Acid, Xenopus |
| الوصف: | Insulin-like growth factor II (IGF-II) is a major fetal growth factor. The IGF-II gene generates multiple mRNAs with different 5' untranslated regions (5' UTRs) that are translated in a differential manner during development. We have identified a human family of three IGF-II mRNA-binding proteins (IMPs) that exhibit multiple attachments to the 5' UTR from the translationally regulated IGF-II leader 3 mRNA but are unable to bind to the 5' UTR from the constitutively translated IGF-II leader 4 mRNA. IMPs contain the unique combination of two RNA recognition motifs and four hnRNP K homology domains and are homologous to the Xenopus Vera and chicken zipcode-binding proteins. IMP localizes to subcytoplasmic domains in a growth-dependent and cell-specific manner and causes a dose-dependent translational repression of IGF-II leader 3 -luciferase mRNA. Mouse IMPs are produced in a burst at embryonic day 12.5 followed by a decline towards birth, and, similar to IGF-II, IMPs are especially expressed in developing epithelia, muscle, and placenta in both mouse and human embryos. The results imply that cytoplasmic 5' UTR-binding proteins control IGF-II biosynthesis during late mammalian development. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| الإتاحة: | https://curis.ku.dk/portal/da/publications/a-family-of-insulinlike-growth-factor-ii-mrnabinding-proteins-represses-translation-in-late-developmentTest(f9d41a70-74c8-11db-bee9-02004c4f4f50).html http://mcb.asm.org/cgi/content/abstract/19/2/1262Test |
| حقوق: | info:eu-repo/semantics/restrictedAccess |
| رقم الانضمام: | edsbas.452F5E21 |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |