نتائج البحث - "Hypoxia-inducible factor-1?"

1

دورية أكاديمية

HIF-1-Independent Mechanisms Regulating Metabolic Adaptation in Hypoxic Cancer Cells.

المؤلفون: Lee, Shen-Han, Golinska, Monika, Griffiths, John R

مصطلحات موضوعية: 2-hydroxyglutarate, AMP-activated protein kinase (AMPK), Myc, cancer metabolism, creatine metabolism, glutamine metabolism, glycolysis, hypoxia, hypoxia-inducible factor-1 (HIF-1), lipid metabolism, phosphatidylinositol 3-kinase (PI3K), Adaptation, Physiological, Animals, Cell Hypoxia, Humans, Hypoxia-Inducible Factor 1, Neoplasms, Signal Transduction

وصف الملف: Electronic; application/pdf

العلاقة: https://www.repository.cam.ac.uk/handle/1810/331181Test

الإتاحة: https://doi.org/10.17863/CAM.78628Test
https://www.repository.cam.ac.uk/handle/1810/331181Test

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2

دورية أكاديمية

Hypoxia Modulates Epithelial Permeability via Regulation of Vascular Endothelial Growth Factor in Airway Epithelia

المساهمون: College of Medicine, Dept. of Otorhinolaryngology, Hyun-Ah Song, Yoo-Suk Kim, Hyung-Ju Cho, Soo In Kim, Min Jung Kang, Ji Hyun Kim, Hyun Jin Min, Ju-Wan Kang, Joo-Heon Yoon, Chang-Hoon Kim, Kim, Chang Hoon, Cho, Hyung Ju

مصطلحات موضوعية: Animals, Cell Hypoxia, Cell Membrane Permeability, Epithelial Cells/metabolism, Epithelium/metabolism, Epithelium/physiopathology, Humans, Hypoxia-Inducible Factor 1, alpha Subunit/metabolism, RNA, Small Interfering/metabolism, Transcriptional Activation/physiology, Up-Regulation, Vascular Endothelial Growth Factor A/metabolism, hypoxia, hypoxia-inducible factor-1, paracellular permeability, sinusitis, vascular endothelial growth factor

العلاقة: AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY; J00113; OAK-2017-07405; https://ir.ymlib.yonsei.ac.kr/handle/22282913/161577Test; T201705244; AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY, Vol.57(5) : 527-535, 2017

الإتاحة: https://doi.org/10.1165/rcmb.2016-0080OCTest
https://ir.ymlib.yonsei.ac.kr/handle/22282913/161577Test

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النص الكامل

3

دورية أكاديمية

Hyperglycemia-induced degradation of HIF-1α contributes to impaired response of cardiomyocytes to hypoxia ; A degradação do HIF-1 induzida pela hiperglicemia contribui para a desregulação na resposta à hipoxia pelos cardiomiócitos

المؤلفون: Ramalho, Ana Rita, Toscano, Adriana, Pereira, Paulo, Girão, Henrique, Gonçalves, Lino, Marques, Carla

مصطلحات موضوعية: Diabetic heart disease, Hypoxia, Hypoxia-inducible factor-1, Cardiomyocytes, Doenças cardiovasculares e diabetes, Hipoxia, HIF-1, Cardiomiócitos, Animals, Cells, Cultured, Hyperglycemia, Hypoxia-Inducible Factor 1, alpha Subunit, Mice, Myocytes, Cardiac, Pyruvaldehyde, Cell Hypoxia

العلاقة: UID/NEU/04539/2013; COMPETE -POCI-01-0145-FEDER-007440; http://hdl.handle.net/10316/102104Test

الإتاحة: https://doi.org/10.1016/j.repc.2016.09.018Test
http://hdl.handle.net/10316/102104Test

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النص الكامل

4

HIF-1-Independent Mechanisms Regulating Metabolic Adaptation in Hypoxic Cancer Cells

المؤلفون: John R. Griffiths, Shen-Han Lee, Monika Golinska

المساهمون: Lee, Shen-Han [0000-0002-6147-2963], Griffiths, John R. [0000-0001-7369-6836], Apollo - University of Cambridge Repository, Griffiths, John R [0000-0001-7369-6836]

المصدر: Cells
Cells, Vol 10, Iss 2371, p 2371 (2021)

وصف الملف: application/zip; application/pdf; text/xml

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cde4ee1337671fc91e5c6ffc6f6e3a8eTest

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Hypoxia-Induced Mesenchymal Stromal Cells Exhibit an Enhanced Therapeutic Effect on Radiation-Induced Lung Injury in Mice due to an Increased Proliferation Potential and Enhanced Antioxidant Ability

المؤلفون: Bailong Li, Mo Zhu, Cheng Li, Fu Gao, Bin Liu, Youjun Zhang, Yang Xu, Jianming Cai, Jicong Du, Yanyong Yang, Hu Liu

المصدر: Cellular Physiology and Biochemistry, Vol 44, Iss 4, Pp 1295-1310 (2017)

مصطلحات موضوعية: Male, 0301 basic medicine, Physiology, Mesenchymal stromal cells, Apoptosis, Antioxidants, lcsh:Physiology, Mice, 0302 clinical medicine, Transforming Growth Factor beta, Pulmonary fibrosis, Medicine, lcsh:QD415-436, Hypoxia, Cells, Cultured, lcsh:QP1-981, Caspase 3, Lung Injury, Cell Hypoxia, Radiation-induced lung injury, 030220 oncology & carcinogenesis, medicine.symptom, Cell Survival, Bone Marrow Cells, Lung injury, Mesenchymal Stem Cell Transplantation, lcsh:Biochemistry, 03 medical and health sciences, EdU assay, Animals, Viability assay, Parenchymal Tissue, Cell Proliferation, Tumor Necrosis Factor-alpha, business.industry, Hypoxia-inducible factor-1, Mesenchymal stem cell, Mesenchymal Stem Cells, Hypoxia (medical), Hypoxia-Inducible Factor 1, alpha Subunit, medicine.disease, Actins, Mice, Inbred C57BL, Transplantation, 030104 developmental biology, Gamma Rays, Immunology, Cancer research, business, Reactive oxygen species, Proto-Oncogene Proteins c-akt

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e348d715f9af6f7aef374fcde927cf45Test
https://www.karger.com/Article/FullText/485490Test

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BNIP3 induction by hypoxia stimulates FASN-dependent free fatty acid production enhancing therapeutic potential of umbilical cord blood-derived human mesenchymal stem cells

المؤلفون: So Hee Ko, Hyun Jik Lee, Sang Hun Lee, Gee Euhn Choi, Young Hyun Jung, Ho Jae Han, Sei Jung Lee

المصدر: Redox Biology, Vol 13, Iss C, Pp 426-443 (2017)
Redox Biology

مصطلحات موضوعية: 0301 basic medicine, CM-H2DCFDA, 2′,7′-dichlorodihydrofluorescein diacetate, FFA, Free fatty acid, FASN, fatty acid synthase, Clinical Biochemistry, PBA, 4-phenyl butyric acid, Apoptosis, Biochemistry, Mice, MAGL, monoacylglycerol lipase, DGAT1, diglyceride acyltransferase 1, Mitophagy, CHOP, CCAAT-enhancer binding protein homologous protein, Fatty acid synthase (FASN), FOXO3, forkhead box, class O3, S.E.M, standard error of mean, Cyclic AMP Response Element-Binding Protein, Hypoxia, lcsh:QH301-705.5, CPT1A, carnitine palmitoyltransferase 1A, Caspase, NAC, N-acetyl-L-cysteine, Mesenchymal stem cell, lcsh:R5-920, UCB-hMSCs, umbilical cord blood-derived hMSCs, HNA, human nuclear antigen, biology, GPAT1, glycerol-3-phsphate acyltransferase 1, TMRE, tetramethylrhodamine ethyl ester, Fatty Acids, Forkhead Box Protein O3, BNIP3, Bcl2/adenovirus E1B 19 kDa protein-interacting protein 3, HIF-1α, hypoxia-inducible factor-1 alpha, Cell Hypoxia, Mitochondria, Cell biology, Fatty Acid Synthase, Type I, Fatty acid synthase, HMSCs, human mesenchymal stem cells, Bcl2/adenovirus E1B 19 kDa protein-interacting protein 3 (BNIP3), FOXO3, FITC, fluorescein isothiocyanate, Stem cell, medicine.symptom, Sterol Regulatory Element Binding Protein 1, lcsh:Medicine (General), Research Paper, eIF-2α, eukaryotic initiation factor 2 alpha, PBS, phosphate buffered solution, Mesenchymal Stem Cell Transplantation, Cell Line, PI, propidium iodide, PA, palmitic acid, 03 medical and health sciences, ROS, reactive oxygen species, TBST, tris-buffered saline containing 0.1% Tween-20, mtROS, mitochondrial ROS, Proto-Oncogene Proteins, CCCP, carbonyl cyanide m-chlorophenyl hydrazine, CHIP, chromatin immunoprecipitation, medicine, Animals, Humans, SCD1, stearoyl-CoA desaturase 1, CBP, CREB-binding protein, SREBP1, sterol regulatory element binding protein 1, Wound Healing, FA, fatty acid, FUNDC1, FUN14 domain containing 1, Organic Chemistry, Membrane Proteins, Mesenchymal Stem Cells, Lipid metabolism, Annexin V, FITC-conjugated annexinV, PINK1, PTEN-induced putative kinase1, Hypoxia (medical), Hypoxia-Inducible Factor 1, alpha Subunit, Molecular biology, BCA, bicinchoninic acid, NT, non-targeting, Oxygen, 030104 developmental biology, lcsh:Biology (General), biology.protein, Reactive Oxygen Species

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed303408c6659c26ed4800f3e9bf3d49Test
https://doi.org/10.1016/j.redox.2017.07.004Test

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Bi-directionally protective communication between neurons and astrocytes under ischemia

المؤلفون: Yick-Chun Yan, Christopher Qian, Fa-Li Zhang, Yu-Fu Zhou, Xiao-Mei Wu, Qian-Qian Luo, Li-Rong Jiang, Ya Ke, Zhong-Ming Qian, Wing-Ho Yung

المصدر: Redox Biology
Redox Biology, Vol 13, Iss C, Pp 20-31 (2017)

مصطلحات موضوعية: 0301 basic medicine, MAPK/ERK pathway, Pathology, Clinical Biochemistry, STAT5, signal transducer and activator of transcription 5, Cell Communication, Biochemistry, chemistry.chemical_compound, Phosphatidylinositol 3-Kinases, 0302 clinical medicine, ERK, extracellular signal-regulated kinase, Bi-directional communication, STAT5 Transcription Factor, lcsh:QH301-705.5, STAT5, Cells, Cultured, IP, ischmia-preconditionning, Neurons, lcsh:R5-920, TUNEL assay, Mitogen-Activated Protein Kinase 3, PI3K, phosphatidylinositol 3-kinase, Glutathione, Cell Hypoxia, Cell biology, JAK-2, Janus kinase-2, medicine.anatomical_structure, rhEPO, recombinant human EPO, IPcNCM, ischemia-preconditioned neuron culture medium, KA, kainic acid, lcsh:Medicine (General), Astrocyte, Research Paper, Cell signaling, medicine.medical_specialty, Kainic acid, MTT, 3-(4,5-dimethylthazol-2-yl)-2,5-diphenyltetrazolinum bromide, Astro-protection, Ischemia, GFAP, glial fibrillary acadic protein, DNA Fragmentation, Biology, CNS, central nervous system, 03 medical and health sciences, MAP2, microtubule-associated protein 2, In vivo, medicine, Animals, L-Lactate Dehydrogenase, Organic Chemistry, medicine.disease, OGD, oxygen glucose deprivation, Rats, Oxygen, 030104 developmental biology, chemistry, lcsh:Biology (General), Astrocytes, HIF-1alpha, hypoxia-inducible factor-1 alpha, biology.protein, EPO, erythropoietin, Reactive Oxygen Species, 030217 neurology & neurosurgery, Anti-apoptosis and anti-oxidant

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cfe9ac220012a9ec3c08b04e07de71d1Test
http://europepmc.org/articles/PMC5447396Test

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A degradação do HIF-1 induzida pela hiperglicemia contribui para a desregulação na resposta à hipoxia pelos cardiomiócitos

المؤلفون: Carla Marques, Paulo Pereira, A. R. Ramalho, Henrique Girão, Adriana Toscano, Lino Gonçalves

المصدر: Revista Portuguesa de Cardiologia, Vol 36, Iss 5, Pp 367-373 (2017)
Revista Portuguesa de Cardiologia (English Edition), Vol 36, Iss 5, Pp 367-373 (2017)
Revista Portuguesa de Cardiologia

مصطلحات موضوعية: 0301 basic medicine, lcsh:Diseases of the circulatory (Cardiovascular) system, medicine.medical_specialty, Cardiomiócitos, Endogeny, Mice, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Ubiquitin, Internal medicine, medicine, Animals, Hipoxia, Myocytes, Cardiac, MTT assay, Viability assay, Diabetic heart disease, Hypoxia, Transcription factor, Cells, Cultured, 030304 developmental biology, General Environmental Science, Cardiomyocytes, 0303 health sciences, biology, Chemistry, Hypoxia-inducible factor-1, Methylglyoxal, HIF-1, Hypoxia (medical), Hypoxia-Inducible Factor 1, alpha Subunit, Pyruvaldehyde, Cell Hypoxia, 3. Good health, Cell biology, Doenças cardiovasculares e diabetes, 030104 developmental biology, Endocrinology, lcsh:RC666-701, Cell culture, 030220 oncology & carcinogenesis, Hyperglycemia, biology.protein, General Earth and Planetary Sciences, medicine.symptom, Cardiology and Cardiovascular Medicine

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0db4d820295ac1b07665a7ea5fbe9deaTest
https://doi.org/10.1016/j.repc.2016.09.018Test

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Activation of the hypoxia pathway in breast cancer tissue and patient survival are inversely associated with tumor ascorbate levels

المؤلفون: Valerie Davey, Helen Morrin, Elizabeth J. Campbell, Gabi U. Dachs, Bridget A. Robinson, Margreet C.M. Vissers

المصدر: BMC Cancer
BMC Cancer, Vol 19, Iss 1, Pp 1-13 (2019)

مصطلحات موضوعية: 0301 basic medicine, Vascular Endothelial Growth Factor A, Cancer Research, Disease-free survival, Breast Neoplasms, Ascorbic Acid, lcsh:RC254-282, Metastasis, 03 medical and health sciences, 0302 clinical medicine, Breast cancer, Surgical oncology, Antigens, Neoplasm, Cell Line, Tumor, Proto-Oncogene Proteins, Genetics, Medicine, Humans, Ascorbate, Carbonic Anhydrase IX, Neoplasm Staging, Retrospective Studies, business.industry, Hypoxia-inducible factor-1, Carcinoma, Ductal, Breast, Cancer, Membrane Proteins, Middle Aged, medicine.disease, lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens, Hypoxia-Inducible Factor 1, alpha Subunit, Prognosis, Primary tumor, Survival Analysis, Cell Hypoxia, Up-Regulation, Gene Expression Regulation, Neoplastic, 030104 developmental biology, Oncology, Hypoxia-inducible factors, 030220 oncology & carcinogenesis, Cancer research, Tumor necrosis factor alpha, Female, Hypoxia Pathway, Neoplasm Grading, business, Research Article

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ee3dab16d80c6566b83bbc5d3024068Test
http://europepmc.org/articles/PMC6448303Test

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HIF-1α protects against oxidative stress by directly targeting mitochondria

المؤلفون: Li Feng, Youping Li, Hong-Sheng Li, Jia-Bi Zhang, Yanni Zhou, Lu Li, Dan Long, Shengfu Li, Xuelu Chen

المصدر: Redox Biology
Redox Biology, Vol 25, Iss, Pp-(2019)

مصطلحات موضوعية: 0301 basic medicine, Liver Cirrhosis, Male, CTAD, C-terminal activation domain, HO-1, heme Oxygenase-1, PARP, cleaved poly (ADP-ribose) polymerase, TFAM, transcription factor A, mitochondrial, Transcription, Genetic, MT-COII, mitochondrial-encoded cytochrome c oxidase II, Clinical Biochemistry, GAPDH, glyceraldehyde 3-phosphate dehydrogenase, TMRM, tetramethylrhodamine methyl ester, MT-CYB, mitochondrial-encoded cytochrome b, HDAC, histone deacetylase, Apoptosis, Mitochondrion, medicine.disease_cause, Biochemistry, HIF-1, hypoxia inducible factor-1, TIMM17A, translocase of inner mitochondrial membrane 17A, Mice, 0302 clinical medicine, HUVEC, human umbilical vein endothelial cell, lcsh:QH301-705.5, GSH, Glutathione, chemistry.chemical_classification, Regulation of gene expression, NFE2L2, Nuclear factor erythroid 2-related factor 2, Membrane Potential, Mitochondrial, lcsh:R5-920, education.field_of_study, ID, inhibitory domain, ROS, Cell Hypoxia, Cell biology, Mitochondria, Protein Transport, lcsh:Medicine (General), Population, PCNA, proliferating cell nuclear antigen, HIF-1α, Down-Regulation, DNA, Mitochondrial, Article, Cell Line, 03 medical and health sciences, ROS, reactive oxygen species, medicine, Animals, Humans, RNA, Messenger, TOMM40, translocase of outer mitochondrial membrane 40, education, Transcription factor, PHD, prolyl hydroxylases, SOD2, superoxide dismutase 2, Reactive oxygen species, Organic Chemistry, WCL, whole cell lysates, Hydrogen Peroxide, Subcellular localization, Hypoxia-Inducible Factor 1, alpha Subunit, mtDNA, mitochondrial DNA, AIF, apoptosis-inducing factor, Mice, Inbred C57BL, Oxidative Stress, 030104 developmental biology, NTAD, N-terminal activation domain, lcsh:Biology (General), chemistry, Cytoprotection, DMOG, dimethyloxaloylglycine, MT-ND1, mitochondrial-encoded NADH dehydrogenase I, nDNA, nuclear DNA, ΔΨm, Mitochondrial membrane potential, CAT, catalase, 030217 neurology & neurosurgery, Oxidative stress, HA, hemagglutinin

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a886e678fab1cdbd21eb362879cc744eTest
http://europepmc.org/articles/PMC6859547Test

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