نتائج البحث - "Kun-Liang Guan"

1

Small Molecule Inhibitors of TEAD Auto-palmitoylation Selectively Inhibit Proliferation and Tumor Growth ofNF2-deficient Mesothelioma

المؤلفون: Jian Li, Kun-Liang Guan, Leonard Post, Andrei W. Konradi, Ying Feng, Xiao Peng, Fa-Xing Yu, Mingyue Ma, Tracy T. Tang

المصدر: Molecular Cancer Therapeutics. 20:986-998

مصطلحات موضوعية: 0301 basic medicine, Cancer Research, Hippo signaling pathway, Chemistry, Cell growth, Effector, In vitro, Merlin (protein), 03 medical and health sciences, 030104 developmental biology, 0302 clinical medicine, Oncology, Palmitoylation, In vivo, 030220 oncology & carcinogenesis, Cancer research, Transcription factor

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::509eed1cc6d2346fbb6bfc63d6fe0e58Test
https://doi.org/10.1158/1535-7163.mct-20-0717Test

2

Induction of AP-1 by YAP/TAZ contributes to cell proliferation and organ growth

المؤلفون: Kun-Liang Guan, Da-Hye Lee, Ja Hyun Koo, Cun-Yu Wang, Dae-Sik Lim, Di Yang, Steven W. Plouffe, Zhipeng Meng

المصدر: Genes Dev
Genes & development, vol 34, iss 1-2

مصطلحات موضوعية: Uveal Neoplasms, medicine.disease_cause, Medical and Health Sciences, Mice, 0302 clinical medicine, Hippo, Transcription (biology), 2.1 Biological and endogenous factors, Aetiology, Promoter Regions, Genetic, Melanoma, Tissue homeostasis, 0303 health sciences, Tumor, Adaptor Proteins, Genes, fos, Organ Size, Biological Sciences, Cell biology, Gene Expression Regulation, Neoplastic, Liver, 030220 oncology & carcinogenesis, Stem Cell Research - Nonembryonic - Non-Human, bilirubin, Biotechnology, Research Paper, c-fos, fos, Biology, liver, Cell Line, Promoter Regions, 03 medical and health sciences, hepatomegaly, Rare Diseases, Genetic, Cell Line, Tumor, Genetics, medicine, cancer, Animals, Humans, Transcription factor, Adaptor Proteins, Signal Transducing, Cell Proliferation, 030304 developmental biology, Neoplastic, Hippo signaling pathway, Cell growth, Human Genome, Psychology and Cognitive Sciences, Signal Transducing, YAP-Signaling Proteins, Promoter, Stem Cell Research, Transcription Factor AP-1, HEK293 Cells, Gene Expression Regulation, Genes, Transcriptional Coactivator with PDZ-Binding Motif Proteins, Cancer cell, Trans-Activators, Mitogens, Carcinogenesis, Gene Deletion, Transcription Factors, Developmental Biology

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4932433e75f0c2b2317020a98402584Test
https://doi.org/10.1101/gad.331546.119Test

3

mTOR as a central hub of nutrient signalling and cell growth

المؤلفون: Kun-Liang Guan, Joungmok Kim

المصدر: Nature Cell Biology. 21:63-71

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8834795c5bdf33559d2f59eb3f385c1Test
https://doi.org/10.1038/s41556-018-0205-1Test

4

Structural insights into TSC complex assembly and GAP activity on Rheb

المؤلفون: Zishuo Yu, Huirong Yang, Xizi Chen, Ning Gao, Yanhui Xu, Hai-Xin Yuan, Ningning Li, Kun-Liang Guan, Jiaxuan Cheng, Jiabei Li, Dan Ye

المصدر: Nature Communications
Nature communications, vol 12, iss 1
Nature Communications, Vol 12, Iss 1, Pp 1-10 (2021)

مصطلحات موضوعية: 0301 basic medicine, Models, Molecular, GTP', General Physics and Astronomy, mTORC1, GTPase, Tuberous Sclerosis Complex 1 Protein, Cell growth, Tuberous Sclerosis, Models, Cryoelectron microscopy, Small GTPase, Tumour-suppressor proteins, Multidisciplinary, biology, Chemistry, GTPase-Activating Proteins, medicine.anatomical_structure, RHEB, Protein Binding, Cell signalling, congenital, hereditary, and neonatal diseases and abnormalities, Science, 1.1 Normal biological development and functioning, Protein domain, General Biochemistry, Genetics and Molecular Biology, Article, Vaccine Related, 03 medical and health sciences, Rare Diseases, Protein Domains, Underpinning research, Biodefense, Tuberous Sclerosis Complex 2 Protein, medicine, Humans, 030102 biochemistry & molecular biology, Prevention, Molecular, General Chemistry, Brain Disorders, nervous system diseases, 030104 developmental biology, HEK293 Cells, biology.protein, Biophysics, Biocatalysis, Ras Homolog Enriched in Brain Protein, TSC1, TSC2, Protein Multimerization

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31f5b1e548f704a6eddafca2d7a0d152Test
https://pubmed.ncbi.nlm.nih.gov/33436626Test

5

Regulation of the Hippo Pathway Transcription Factor TEAD

المؤلفون: Hyun Woo Park, Kun-Liang Guan, Kimberly C. Lin

المصدر: Trends in Biochemical Sciences. 42:862-872

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3bdd843e896a6a7d4a0299895b84d0eaTest
https://doi.org/10.1016/j.tibs.2017.09.003Test

6

Osmotic stress‐induced phosphorylation by NLK at Ser128 activates YAP

المؤلفون: Steven W. Plouffe, Audrey W. Hong, Kun-Liang Guan, Hai-Xin Yuan, Wantae Kim, Zhipeng Meng, Sungho Moon, Eek-hoon Jho

المصدر: EMBO reports. 18:72-86

مصطلحات موضوعية: 0301 basic medicine, Hippo signaling pathway, Osmotic shock, Kinase, Chemistry, Cell growth, Articles, Biochemistry, Cell biology, 03 medical and health sciences, Crosstalk (biology), 030104 developmental biology, Genetics, Phosphorylation, Molecular Biology, Nuclear localization sequence, Tissue homeostasis

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0337d392c4ea53ece1a34c6f738c522dTest
https://doi.org/10.15252/embr.201642681Test

7

Thromboxane A2 Activates YAP/TAZ Protein to Induce Vascular Smooth Muscle Cell Proliferation and Migration

المؤلفون: Zhen Wang, Xin Zhou, Yi Ping Sun, Fulong Li, Yue Xiong, Hai Xin Yuan, Xu Feng, Meng Tian Li, Ying Yu, Kun-Liang Guan, Zhipeng Meng, Peng Liu

المصدر: Journal of Biological Chemistry. 291:18947-18958

مصطلحات موضوعية: 0301 basic medicine, Vascular smooth muscle, Myocytes, Smooth Muscle, Cell, 030204 cardiovascular system & hematology, GTP-Binding Protein alpha Subunits, G12-G13, Biochemistry, Muscle, Smooth, Vascular, Receptors, Thromboxane A2, Prostaglandin H2, Thromboxane A2, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Cell Movement, medicine, Humans, Receptor, Molecular Biology, Adaptor Proteins, Signal Transducing, Cell Proliferation, Hippo signaling pathway, Cell growth, Intracellular Signaling Peptides and Proteins, YAP-Signaling Proteins, Cell migration, Cell Biology, Bridged Bicyclo Compounds, Heterocyclic, Phosphoproteins, Actin cytoskeleton, Cell biology, 030104 developmental biology, medicine.anatomical_structure, chemistry, Gene Knockdown Techniques, Transcriptional Coactivator with PDZ-Binding Motif Proteins, Fatty Acids, Unsaturated, Trans-Activators, HeLa Cells, Signal Transduction, Transcription Factors

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::215fc08f6a0314506c331b8dc5ebc67dTest
https://doi.org/10.1074/jbc.m116.739722Test

8

Decoding WW Domain Tandem-mediated Target Recognitions in Tissue Growth and Cell Polarity

المؤلفون: Mingjie Zhang, Zhou Yang, Zeyang Ji, Zhijie Lin, Kun-Liang Guan, Ruiling Xie

المصدر: eLife
eLife, Vol 8 (2019)

مصطلحات موضوعية: 0301 basic medicine, Scaffold protein, Structural Biology and Molecular Biophysics, LATS, Mice, 0302 clinical medicine, Cell polarity, Protein Interaction Maps, Biology (General), KIBRA, 0303 health sciences, biology, Chemistry, General Neuroscience, Brain, Cell Polarity, General Medicine, Cell cycle, Cell biology, Protein Transport, Hippo signaling, 030220 oncology & carcinogenesis, Medicine, YAP, Synaptic signaling, Protein Binding, Research Article, WW domain tandem, QH301-705.5, Polarity (physics), Science, MAGI, DNA-binding protein, General Biochemistry, Genetics and Molecular Biology, WW Domains, WW domain, 03 medical and health sciences, Animals, Cell Proliferation, 030304 developmental biology, General Immunology and Microbiology, Cell growth, E. coli, Proteins, 030104 developmental biology, Structural biology, biology.protein

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0cc7bb47a7e9d98ef8d4e659d8a222d6Test
https://doi.org/10.1101/694976Test

9

BRCA1/BARD1-dependent ubiquitination of NF2 regulates Hippo-YAP1 signaling

المؤلفون: Kun-Liang Guan, Inder M. Verma, Jolene K. Diedrich, Yasushi Soda, Audrey W. Hong, Steve Plouffe, Narayana Yeddula, James J. Moresco, Sachin Verma, Gerald M. Pao, Quan Zhu, Toshiro Moroishi

المصدر: Proceedings of the National Academy of Sciences of the United States of America, vol 116, iss 15

مصطلحات موضوعية: Hippo, Ubiquitin, 2.1 Biological and endogenous factors, Aetiology, skin and connective tissue diseases, YAP1, Neurofibromin 2, Tumor, Multidisciplinary, biology, Chemistry, BRCA1 Protein, Adaptor Proteins, Cell biology, Ubiquitin ligase, PNAS Plus, Phosphorylation, Female, Signal Transduction, 1.1 Normal biological development and functioning, Ubiquitin-Protein Ligases, Mutation, Missense, Breast Neoplasms, Protein Serine-Threonine Kinases, ubiquitination, Cell Line, Underpinning research, BARD1, Cell Line, Tumor, Breast Cancer, cancer, Humans, Hippo Signaling Pathway, Adaptor Proteins, Signal Transducing, Cell Proliferation, Hippo signaling pathway, Cell growth, Tumor Suppressor Proteins, Signal Transducing, Ubiquitination, YAP-Signaling Proteins, BRCA1, Phosphoproteins, HEK293 Cells, Amino Acid Substitution, NF2, Mutation, biology.protein, Ectopic expression, Generic health relevance, Missense, Transcription Factors

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b7f8109eb2e6e151a1497c5527ee2fcTest
https://pubmed.ncbi.nlm.nih.gov/30918126Test

10

GPCR signaling inhibits mTORC1 via PKA phosphorylation of Raptor

المؤلفون: Hai Xin Yuan, Audrey W. Hong, Delong Meng, Fa-Xing Yu, Wai Ling Macrina Lam, Kun-Liang Guan, Susan S. Taylor, Jenna L. Jewell, Vivian Fu, Chase H. Melick, Huanyu Wang

المصدر: eLife
eLife, Vol 8 (2019)

مصطلحات موضوعية: 0301 basic medicine, mTORC1, Receptors, G-Protein-Coupled, 0302 clinical medicine, Receptors, cell biology, 2.1 Biological and endogenous factors, Aetiology, Biology (General), Phosphorylation, Receptor, cancer biology, Cancer Biology, Chemistry, General Neuroscience, General Medicine, Cell biology, Medicine, Signal transduction, biological phenomena, cell phenomena, and immunity, Signal Transduction, Research Article, Human, Gs alpha subunit, QH301-705.5, 1.1 Normal biological development and functioning, Science, Mechanistic Target of Rapamycin Complex 1, General Biochemistry, Genetics and Molecular Biology, Cell Line, 03 medical and health sciences, G-Protein-Coupled, Underpinning research, Animals, Humans, human, Protein kinase A, Protein Processing, mouse, G protein-coupled receptor, General Immunology and Microbiology, Cell growth, Post-Translational, Regulatory-Associated Protein of mTOR, Cell Biology, Cyclic AMP-Dependent Protein Kinases, 030104 developmental biology, cancer cells, cells, Biochemistry and Cell Biology, Protein Processing, Post-Translational, 030217 neurology & neurosurgery

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ffb298648d804f7699381ac8a2b44fdTest
https://pubmed.ncbi.nlm.nih.gov/31112131Test

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