العنوان البديل: mTOR pathway and its role in rheumatologic diseases.

المؤلفون: Gümüş, Zeynep Zehra¹ zeynepzehrag@gmail.com, Soypaçacı, Zeki², Akar, Servet³

المصدر: Journal of Turkish Society for Rheumatology. Dec2019, Vol. 11 Issue 2, p132-156. 25p.

مصطلحات موضوعية: *MTOR inhibitors, *TRANSPLANTATION of organs, tissues, etc., *CELL growth, *CELL proliferation, *CELL physiology

المؤلفون: Linlin Zhao¹, Xinbo Wang¹, Yue Yu², Lu Deng², Lei Chen², Xiaoping Peng², Chenchen Jiao³, Guoli Gao², Xiao Tan⁴, Weijuan Pan², Xin Ge⁴ xin.ge@tongji.edu.cn, Ping Wang² wangp@tongji.edu.cn

المصدر: Journal of Biological Chemistry. 3/30/2018, Vol. 293 Issue 13, p4883-4892. 10p.

مصطلحات موضوعية: *MTOR inhibitors, *UBIQUITINATION, *ALDEHYDES, *CELL growth, *CELL proliferation

المؤلفون: Miyahara, Hiroaki¹, Yadavilli, Sridevi², Natsumeda, Manabu¹, Rubens, Jeffrey A.³, Rodgers, Louis⁴, Kambhampati, Madhuri², Taylor, Isabella C.³, Kaur, Harpreet³, Asnaghi, Laura¹, Eberhart, Charles G.¹, Warren, Katherine E.⁴, Nazarian, Javad^2,5, Raabe, Eric H.^1,3 eraabe2@jhmi.edu, Rubens, Jeffrey³, Taylor, Isabella³

المصدر: Cancer Letters. Aug2017, p110-116. 7p.

مصطلحات موضوعية: *MTOR inhibitors, *KINASE inhibitors, *RAPAMYCIN, *CELL growth, *CELL proliferation, *RADIOTHERAPY, *APOPTOSIS, *GLIOMA treatment, *PROTEIN metabolism, *CANCER cells, *TIME, *CANCER invasiveness, *GLIOMAS, *CELL physiology, *CELLULAR signal transduction, *CELL motility, *RADIATION-sensitizing agents, *DOSE-effect relationship in pharmacology, *RESEARCH funding, *CELL lines, *ANIMALS, *MICE, *PHOSPHORYLATION, *PHARMACODYNAMICS, *PHYSIOLOGICAL effects of radiation

المؤلفون: Seyed Mohammad Abedi, Samaneh Vaseghi, Nasrin Abbasi Gharibkandi, Alireza Mardanshahi, Sajjad Molavipordanjani

المصدر: Molecular Biology Reports. 48:1-14

مصطلحات موضوعية: Cell Survival, medicine.medical_treatment, Apoptosis, Radiation Tolerance, Phosphatidylinositol 3-Kinases, Cell Line, Tumor, Neoplasms, Autophagy, Genetics, medicine, Humans, Radiosensitivity, Protein Kinase Inhibitors, Molecular Biology, Protein kinase B, PI3K/AKT/mTOR pathway, Cell Proliferation, Phosphoinositide-3 Kinase Inhibitors, Cell growth, Akt/PKB signaling pathway, business.industry, TOR Serine-Threonine Kinases, Cell Cycle, Cancer, MTOR Inhibitors, General Medicine, medicine.disease, Radiation therapy, Cancer research, business, Proto-Oncogene Proteins c-akt, Signal Transduction

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18fdb87979d16875fbb742eee534b74bTest
https://doi.org/10.1007/s11033-021-06607-3Test

المؤلفون: Vivek Asati, Kamalpreet Kaur, Arjun Anant

المصدر: Anti-cancer agents in medicinal chemistry. 22(6)

مصطلحات موضوعية: Pharmacology, Cancer Research, Everolimus, Cell growth, TOR Serine-Threonine Kinases, mTORC1, MTOR Inhibitors, Mechanistic Target of Rapamycin Complex 2, Mechanistic Target of Rapamycin Complex 1, mTORC2, Temsirolimus, Ridaforolimus, chemistry.chemical_compound, chemistry, medicine, Quinazoline, Cancer research, Molecular Medicine, Humans, Proto-Oncogene Proteins c-akt, PI3K/AKT/mTOR pathway, medicine.drug, Cell Proliferation

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::482a6c65d4965a6732c513c6defd0c10Test
https://pubmed.ncbi.nlm.nih.gov/34288843Test

المؤلفون: Kuan-Wei Lee, Max K. Leong, Ching-Feng Weng, Varadharajan Thiyagarajan

المصدر: Journal of Biomolecular Structure and Dynamics. 36:4220-4234

مصطلحات موضوعية: Male, 0301 basic medicine, Curcumin, Cell Survival, In silico, Biology, Rats, Sprague-Dawley, Serine, 03 medical and health sciences, 0302 clinical medicine, Structural Biology, Hepatic Stellate Cells, Animals, Phosphorylation, Threonine, Protein Kinase Inhibitors, Molecular Biology, Cells, Cultured, PI3K/AKT/mTOR pathway, Cell Proliferation, Sirolimus, Dose-Response Relationship, Drug, Kinase, Cell growth, TOR Serine-Threonine Kinases, Ribosomal Protein S6 Kinases, 70-kDa, General Medicine, Discovery and development of mTOR inhibitors, Cell biology, Molecular Docking Simulation, 030104 developmental biology, 030220 oncology & carcinogenesis, Hepatic stellate cell

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb0d95f4ed856b4dbefe3bd369c0c9acTest
https://doi.org/10.1080/07391102.2017.1411295Test

المؤلفون: Hana Kunkel, Juan Carlos Roa, Jaime A. Espinoza, Ismael Riquelme, Helga Weber, Bruno Nervi, Carolina Bizama, Pamela Leal, Stefan Stein, Manuel Grez, Juan Carlos Araya, Patricia García

المصدر: Oncotarget

مصطلحات موضوعية: medicine.medical_specialty, mTOR inhibitors, Guanine, medicine.medical_treatment, Blotting, Western, Apoptosis, Mice, SCID, Biology, Immunoenzyme Techniques, gallbladder cancer, Mice, In vivo, Cell Movement, Mice, Inbred NOD, Internal medicine, medicine, Tumor Cells, Cultured, Animals, Humans, Viability assay, ddc:610, Gallbladder cancer, Phosphorylation, PI3K/AKT/mTOR pathway, Cell Proliferation, gallbladder cancer xenografts, Sirolimus, Chemotherapy, Antibiotics, Antineoplastic, Cell growth, rapamycin, medicine.disease, Xenograft Model Antitumor Assays, WYE-354, Endocrinology, Oncology, Cancer research, Drug Therapy, Combination, Gallbladder Neoplasms, medicine.drug, Signal Transduction, Research Paper

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0be4c7ecf215ddbb9fdf93815028af7dTest
https://pubmed.ncbi.nlm.nih.gov/26397134Test

المؤلفون: Mikhail V. Blagosklonny, Zoya N. Demidenko, Olga V. Leontieva

المصدر: Oncotarget

مصطلحات موضوعية: Senescence, Cyclin-Dependent Kinase Inhibitor p21, Aging, Indoles, senescence, Immunoblotting, mTORC1, Mechanistic Target of Rapamycin Complex 2, Biology, Mechanistic Target of Rapamycin Complex 1, Muscle hypertrophy, Cell Line, Tumor, Animals, Humans, quiescence, PI3K/AKT/mTOR pathway, Cellular Senescence, Cell Proliferation, Sirolimus, Dose-Response Relationship, Drug, Kinase, Cell growth, TOR Serine-Threonine Kinases, Blood Proteins, Cell cycle, Discovery and development of mTOR inhibitors, Cell biology, Oncology, Purines, geroconversion, Multiprotein Complexes, Research Perspective, mTOR

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ddd208181c75c7d8ca6a1b625f7e2b4Test
https://pubmed.ncbi.nlm.nih.gov/26375366Test

المؤلفون: Takayuki Motoki, Tomoki Yamatsuji, Yasuhiro Fujiwara, Toshio Nishikawa, Zhigang Wang, Takuya Fukazawa, Yasuko Tomono, Yasuhiro Shirakawa, Munenori Takaoka, Kazufumi Sakurama, Toshiyoshi Fujiwara, Huifang Hao, Xiaohong Bao, Toshiaki Ohara, Noriaki Tanaka, Yoshio Naomoto

مصطلحات موضوعية: Cancer Research, Esophageal Neoplasms, Pharmacology, Mice, Cell Line, Tumor, temsirolimus, medicine, Animals, Humans, esophageal cancer, prolonged survival, Protein Kinase Inhibitors, PI3K/AKT/mTOR pathway, Cell Proliferation, Sirolimus, business.industry, Cell growth, TOR Serine-Threonine Kinases, molecular-targeted therapy, Esophageal cancer, medicine.disease, Discovery and development of mTOR inhibitors, Xenograft Model Antitumor Assays, digestive system diseases, Temsirolimus, Tumor Burden, Enzyme Activation, Disease Models, Animal, Oncology, Cancer research, mTOR, Carcinoma, Squamous Cell, Molecular Medicine, Signal transduction, Antiproliferative effect, business, medicine.drug, Research Paper, Signal Transduction

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac6ea9e90a881c88b900853f2e85791dTest
https://europepmc.org/articles/PMC3595305Test/

المؤلفون: Preeti Trisal, Chien-Hsing Chang, Roberto Arrojo, David M. Goldenberg, Thomas M. Cardillo

المصدر: BMC Cancer

مصطلحات موضوعية: Cancer Research, medicine.medical_specialty, mTOR inhibitors, medicine.medical_treatment, viruses, Down-Regulation, Receptor, IGF Type 1, 03 medical and health sciences, chemistry.chemical_compound, Hex-hR1, 0302 clinical medicine, Dock-and-Lock, Internal medicine, Cell Line, Tumor, 1R-2b, Genetics, medicine, Animals, Humans, Receptor, Carcinoma, Renal Cell, Protein Kinase Inhibitors, PI3K/AKT/mTOR pathway, 030304 developmental biology, Cell Proliferation, 0303 health sciences, Cell growth, business.industry, Growth factor, TOR Serine-Threonine Kinases, Drug Synergism, Insulin-like growth factor-I receptor, Temsirolimus, Kidney Neoplasms, Renal cell carcinoma, 3. Good health, Endocrinology, Oncology, chemistry, Cell culture, Drug Resistance, Neoplasm, 030220 oncology & carcinogenesis, Cancer research, Signal transduction, Growth inhibition, business, medicine.drug, Research Article

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a588fefc96195b1aefa113ac1a42978fTest
https://pubmed.ncbi.nlm.nih.gov/23548153Test