التفاصيل البيبلوغرافية
| العنوان: |
Importance of Proactive Treatment of Depression in Lewy Body Dementias: The Impact on Hippocampal Neurogenesis and Cognition in a Post-Mortem Study. |
| المؤلفون: |
Gatt, ariana, Ekonomou, antigoni, Somani, alyma, Thuret, Sandrine, Howlett, David, Corbett, anne, Johnson, Mary, Perry, Elaine, attems, Johannes, Francis, Paul, aarsland, Dag, Ballard, Clive |
| المصدر: |
Dementia & Geriatric Cognitive Disorders; Apr2018, Vol. 44 Issue 5/6, p283-293, 11p, 1 Diagram, 2 Charts, 1 Graph |
| مصطلحات موضوعية: |
CHOLINESTERASE inhibitors, HIPPOCAMPUS physiology, DRUG therapy for Parkinson's disease, SEROTONIN uptake inhibitors, AUTOPSY, CELL differentiation, COMBINATION drug therapy, COGNITION, DEMENTIA, MENTAL depression, LEWY body dementia, NERVE tissue proteins, STEM cells, CYTOMETRY, THERAPEUTICS |
| مستخلص: |
Objective: To examine the impact of selective serotonin reuptake inhibitors (SSRIs) and depression on neurogenesis and cognition in dementia with Lewy bodies (DLB) and Parkinson disease dementia (PDD). Methods: Late-stage progenitor cells were quantified in the subgranular zone (SGZ) of the hippocampal dentate gyrus of DLB/PDD patients (n = 41) and controls without dementia (n = 15) and compared between treatment groups (unmedicated, SSRIs, acetyl cholinesterase inhibitors [AChEIs], combined SSRIs and AChEIs). Results: DLB/PDD patients had more doublecortin-positive cells in the SGZ compared to controls. The doublecortin-positive cell count was higher in the SGZ of patients treated with SSRIs and correlated to higher cognitive scores. Conclusion: SSRI treatment was associated with increased hippocampal neurogenesis and preservation of cognition in DLB/PDD patients. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
