التفاصيل البيبلوغرافية
| العنوان: |
Age-associated up-regulation of a negative co-stimulatory receptor PD-1 in mouse CD4+ T cells |
| المؤلفون: |
Shimada, Yukiko1, Hayashi, Masami1, Nagasaka, Yasuhiko2, Ohno-Iwashita, Yoshiko1, Inomata, Mitsushi1 minomata@tmig.or.jp |
| المصدر: |
Experimental Gerontology. Aug2009, Vol. 44 Issue 8, p517-522. 6p. |
| مصطلحات موضوعية: |
*LYMPHOCYTE aging, *AGE factors in disease, *T cells, *CD4 antigen, *MEMBRANE proteins, *CELL receptors, *LABORATORY mice, *CELL death |
| مستخلص: |
Abstract: To explore whether any co-stimulatory receptor(s) for TCR signaling is involved in the age-associated decline in T-cell function, we analyzed changes in these receptors in freshly isolated mouse CD4+ T cells during aging. Both the mRNA and protein expression levels of CTLA-4 and PD-1, negative co-stimulatory receptors, increase with aging. No such changes are observed for CD28, a positive regulatory receptor. PD-1 is highly expressed on the surface of old, but not young, mouse T cells, while the level of surface-expressed CTLA-4 is very low regardless of age. PD-1 is preferentially expressed on the surface of effector-memory (CD44hiCD62Llo) T cells, a subset that increases with aging. CD4+PD-1+ T cells from old mice exhibit proliferative hyporesponsiveness. These results suggest that the up-regulation of surface-expressed PD-1 may cause the age-dependent functional decline in effector-memory T cells. [Copyright &y& Elsevier] |
| قاعدة البيانات: |
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