التفاصيل البيبلوغرافية
| العنوان: |
Trans cohort metabolic reprogramming towards glutaminolysis in long-term successfully treated HIV-infection. |
| المؤلفون: |
Mikaeloff, Flora1 (AUTHOR), Svensson Akusjärvi, Sara1 (AUTHOR), Ikomey, George Mondinde2,3 (AUTHOR), Krishnan, Shuba1 (AUTHOR), Sperk, Maike1 (AUTHOR), Gupta, Soham1 (AUTHOR), Magdaleno, Gustavo Daniel Vega4 (AUTHOR), Escós, Alejandra1 (AUTHOR), Lyonga, Emilia2,3 (AUTHOR), Okomo, Marie Claire2,3 (AUTHOR), Tagne, Claude Tayou3 (AUTHOR), Babu, Hemalatha5,6 (AUTHOR), Lorson, Christian L.7,8 (AUTHOR), Végvári, Ákos9 (AUTHOR), Banerjea, Akhil C.10 (AUTHOR), Kele, Julianna11 (AUTHOR), Hanna, Luke Elizabeth5 (AUTHOR), Singh, Kamal7,8 (AUTHOR), de Magalhães, João Pedro4 (AUTHOR), Benfeitas, Rui12 (AUTHOR) |
| المصدر: |
Communications Biology. 1/11/2022, Vol. 5 Issue 1, p1-12. 12p. |
| مصطلحات موضوعية: |
*HIV-positive persons, *ANTIRETROVIRAL agents, *MIDDLE-income countries, *NEUROTRANSMITTERS, *CELL death |
| مصطلحات جغرافية: |
CAMEROON, INDIA |
| مستخلص: |
Despite successful combination antiretroviral therapy (cART), persistent low-grade immune activation together with inflammation and toxic antiretroviral drugs can lead to long-lasting metabolic flexibility and adaptation in people living with HIV (PLWH). Our study investigated alterations in the plasma metabolic profiles by comparing PLWH on long-term cART(>5 years) and matched HIV-negative controls (HC) in two cohorts from low- and middle-income countries (LMIC), Cameroon, and India, respectively, to understand the system-level dysregulation in HIV-infection. Using untargeted and targeted LC-MS/MS-based metabolic profiling and applying advanced system biology methods, an altered amino acid metabolism, more specifically to glutaminolysis in PLWH than HC were reported. A significantly lower level of neurosteroids was observed in both cohorts and could potentiate neurological impairments in PLWH. Further, modulation of cellular glutaminolysis promoted increased cell death and latency reversal in pre-monocytic HIV-1 latent cell model U1, which may be essential for the clearance of the inducible reservoir in HIV-integrated cells. Mikaeloff et al. use untargeted and targeted LC-MS/MS-based plasma metabolic profiling to discover dysregulated metabolism including that of glutaminolysis in individuals living with HIV. Furthermore, decreased levels of neurosteroids were detected suggesting a potential connection between HIV and neurological impairment. [ABSTRACT FROM AUTHOR] |
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