التفاصيل البيبلوغرافية
| العنوان: |
Bendless modulates JNK-mediated cell death and migration in Drosophila. |
| المؤلفون: |
Ma, X1, Li, W1, Yu, H1, Yang, Y1, Li, M1, Xue, L2, Xu, T3 |
| المصدر: |
Cell Death & Differentiation. Mar2014, Vol. 21 Issue 3, p407-415. 9p. 6 Color Photographs, 1 Graph. |
| مصطلحات موضوعية: |
*DROSOPHILA development, *CELL death, *CANCER invasiveness, *CELL migration, *METAZOA, *UBIQUITINATION |
| مستخلص: |
The TNF-JNK pathway is a highly conserved signaling pathway that regulates a wide spectrum of biological processes including cell death and migration. To further delineate this pathway, we carried out a genetic screen for dominant modifiers of the cell death phenotype triggered by ectopic expression of Eiger (Egr), the Drosophila TNF ortholog. Here we show that Bendless (Ben), an E2 ubiquitin-conjugating enzyme, modulates Egr-induced JNK activation and cell death through dTRAF2. Furthermore, Ben physically interacts with dTRAF2 and regulates Egr-induced dTRAF2 polyubiquitination. Finally, Ben is required for JNK-dependent tumor progression, cell migration, oxidative stress resistance and longevity. Our results indicate that Ben constitutes an essential component of the evolutionarily conserved TNF-JNK pathway that modulates cell death and invasion, tumor progression, stress response and lifespan in metazoans. [ABSTRACT FROM AUTHOR] |
| قاعدة البيانات: |
Academic Search Index |
Full Text Finder