An update on cohesin function as a ‘molecular glue’ on chromosomes and spindles
| العنوان: | An update on cohesin function as a ‘molecular glue’ on chromosomes and spindles |
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| المؤلفون: | Richard W. Wong |
| المصدر: | Cell Cycle. 9:1754-1758 |
| بيانات النشر: | Informa UK Limited, 2010. |
| سنة النشر: | 2010 |
| مصطلحات موضوعية: | Centrosome, Cohesin complex, Cohesin, Chromosomal Proteins, Non-Histone, Kinetochore, Nuclear Proteins, Cell Cycle Proteins, Spindle Apparatus, Cell Biology, Biology, Phosphoproteins, Chromosomes, Spindle apparatus, Cell biology, DNA-Binding Proteins, Establishment of sister chromatid cohesion, Chondroitin Sulfate Proteoglycans, Centromere, Chromosomes, Human, Humans, biological phenomena, cell phenomena, and immunity, Separase, Molecular Biology, Developmental Biology, Anaphase |
| الوصف: | One of the critical events in mitosis is proper sister chromatid cohesion, which is mediated by a protein complex called cohesin. The cohesin complex is best known for its role in tethering the sister DNA molecules. This review summarizes recent progress in understanding the functions of cohesin, and of its major subunits, SMC1, SMC3, Scc1 and Scc3. It is now clear that cohesin also plays crucial roles in controlling transcription and gene expression, DNA damage repair and spindle pole formation; functions that are beyond the traditional view of cohesin as a 'molecular glue' that holds sister chromosomes together. |
| تدمد: | 1551-4005 1538-4101 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f78ca221c5f30a33ff122f41b46180fbTest https://doi.org/10.4161/cc.9.9.11806Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....f78ca221c5f30a33ff122f41b46180fb |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15514005 15384101 |
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