المؤلفون: Roberta Mazzone, Rossella Fioravanti, Ciro Mercurio, Mario Varasi, Gerald Brosch, Lucia Altucci, Antonello Mai, Mariarosaria Conte, Angela Nebbioso, Sergio Valente, Clemens Zwergel, Elisabetta Di Bello

المساهمون: Zwergel, C., Di Bello, E., Fioravanti, R., Conte, M., Nebbioso, A., Mazzone, R., Brosch, G., Mercurio, C., Varasi, M., Altucci, L., Valente, S., Mai, A.

مصطلحات موضوعية: Stereochemistry, Pyridines, Cellular differentiation, Antineoplastic Agents, Hydroxamic Acids, 01 natural sciences, Biochemistry, Histone Deacetylases, chemistry.chemical_compound, Structure-Activity Relationship, Drug Discovery, Tumor Cells, Cultured, cancer, Humans, Anilides, General Pharmacology, Toxicology and Pharmaceutics, histone deacetylase inhibitor, IC50, Cell Proliferation, Pharmacology, Dose-Response Relationship, Drug, Molecular Structure, 010405 organic chemistry, Organic Chemistry, apoptosi, Recombinant Proteins, chromatin, histone deacetylase inhibitors, apoptosis, cell differentiation, 0104 chemical sciences, Histone Deacetylase Inhibitors, Isoenzymes, 010404 medicinal & biomolecular chemistry, chemistry, Cell culture, Apoptosis, Acrylamide, Cancer cell, Molecular Medicine, Histone deacetylase, Drug Screening Assays, Antitumor, K562 cells

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d063c7f21f17821a69c1a32de418cc4Test
http://hdl.handle.net/11573/1467228Test

المؤلفون: Feng Chen, Antonio Coluccia, Erica Di Cesare, Giulio Dondio, Ciro Mercurio, Ernest Hamel, Alessandra Soriani, Mario Varasi, Patrizia Lavia, Bruno Maresca, Marianna Nalli, Yicheng Ni, Eleonora Da Pozzo, Claudia Martini, Giuseppe La Regina, Marlein Miranda Cona, Maria Luisa Iannitto, Ruoli Bai, Barbara Costa, Amalia Porta, Sveva Pelliccia, Junjie Li, Andrea Brancale, Romano Silvestri, Ilaria Granata, Angela Santoni, Whilelmina Maria Rensen, Ettore Novellino, Valeria Famiglini, Francesco Piscitelli, Stefania Vultaggio, Alessia Reggio

المساهمون: La Regina, G., Bai, R., Rensen, W. M., Di Cesare, E., Coluccia, A., Piscitelli, F., Famiglini, V., Reggio, A., Nalli, M., Pelliccia, S., Da Pozzo, E., Costa, B., Granata, I., Porta, A., Maresca, B., Soriani, A., Iannitto, M. L., Santoni, A., Li, J., Cona, M. M., Chen, F., Ni, Y., Brancale, A., Dondio, G., Vultaggio, S., Varasi, M., Mercurio, C., Martini, C., Hamel, E., Lavia, P., Novellino, Ettore, Silvestri, R.

المصدر: Journal of medicinal chemistry (Online) 56 (2013): 123–149.
info:cnr-pdr/source/autori:La Regina G, Bai R, Rensen WM, Di Cesare E, Coluccia A, Piscitelli F, Famiglini V, Reggio A, Nalli M, Pelliccia S, Da Pozzo E, Costa B, Granata I, Porta A, Maresca B, Soriani A, Iannitto ML, Santoni A, Li J, Miranda Cona M, Chen F, Ni Y, Brancale A, Dondio G, Vultaggio S, Varasi M, Mercurio C, Martini C, Hamel E, Lavia P, Novellino E, Silvestri R/titolo:Toward highly potent cancer agents by modulating the C-2 group of the arylthioindole class of tubulin polymerization inhibitors./doi:/rivista:Journal of medicinal chemistry (Online)/anno:2013/pagina_da:123/pagina_a:149/intervallo_pagine:123–149/volume:56

مصطلحات موضوعية: Indoles, Pyridines, anticancer, tubulin, Pharmacology, Polymerization, Mice, chemistry.chemical_compound, Tubulin, Rhabdomyosarcoma, Drug Discovery, Cytochrome P-450 Enzyme Inhibitors, Membrane Potential, Mitochondrial, biology, Chemistry, Cell Cycle, Liver Neoplasms, Imidazoles, Tubulin Modulators, Vinblastine, Biochemistry, Microsomes, Liver, Molecular Medicine, medicine.drug, Mitosis, Antineoplastic Agents, anticancer, Article, Permeability, RS, RC0254, Structure-Activity Relationship, Cell Line, Tumor, medicine, Animals, Humans, Cell Proliferation, Combretastatin, Cell growth, Tubulin Polymerization Inhibitors, arylthioindole, Solubility, Drug Resistance, Neoplasm, Cell culture, Cancer cell, Microsome, biology.protein, Caco-2 Cells, Drug Screening Assays, Antitumor, Reactive Oxygen Species

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3c53b8a1246ca046ba51a980e681ff1Test
http://hdl.handle.net/11588/573348Test

المؤلفون: Angela Santoni, Alessandra Soriani, Romano Silvestri, Bruno Maresca, Cristiano Ferlini, Valerio Gatti, Ruoli Bai, Ciro Mercurio, Willeke Rensen, Antonio Lavecchia, Giulio Dondio, Francesco Piscitelli, Ernest Hamel, Alessio Bolognesi, Maria Luisa Iannitto, Mario Varasi, Patrizia Lavia, Andrea Brancale, Ilaria Granata, Antonio Coluccia, Giuseppe La Regina, Amalia Porta, Ettore Novellino, Marisa Mariani

المساهمون: La Regina, G., Bai, R., Rensen, W., Coluccia, A., Piscitelli, F., Gatti, V., Bolognesi, A., Lavecchia, Antonio, Granata, I., Porta, A., Maresca, B., Soriani, A., Iannitto, M. L., Mariani, M., Santoni, A., Brancale, A., Ferlini, C., Dondio, G., Varasi, M., Mercurio, C., Hamel, E., Lavia, P., Novellino, Ettore, Silvestri, R.

المصدر: Journal of medicinal chemistry 54 (2011): 8394–8406. doi:10.1021/jm2012886
info:cnr-pdr/source/autori:La Regina G, Bai R, Rensen W, Coluccia A, Piscitelli F, Gatti V, Bolognesi A, Lavecchia A, Granata I, Porta A, Maresca B, Soriani A, Iannitto ML, Mariani M, Santoni A, Brancale A, Ferlini C, Dondio MG, Varasi M, Mercurio C, Hamel E, Lavia P, Novellino E, Silvestri R./titolo:Design and Synthesis of 2-Heterocyclyl-3-arylthio-1H-indoles as Potent Tubulin Polymerization and Cell Growth Inhibitors with Improved Metabolic Stability/doi:10.1021%2Fjm2012886/rivista:Journal of medicinal chemistry/anno:2011/pagina_da:8394/pagina_a:8406/intervallo_pagine:8394–8406/volume:54

مصطلحات موضوعية: Male, Indoles, Administration, Oral, Pharmacology, Docking, Mice, chemistry.chemical_compound, Drug Discovery, Caspase 3, Cell Cycle, Tubulin Modulators, Vinblastine, Paclitaxel, Biochemistry, Injections, Intravenous, Microsomes, Liver, Molecular Medicine, Cancer Cell, medicine.drug, Biological Availability, Mice, Nude, Antineoplastic Agents, Microtubule, Thiophenes, In Vitro Techniques, Article, Cell Line, Anticancer Agent, Structure-Activity Relationship, Pharmacokinetics, Cell Line, Tumor, Breast Cancer, medicine, Animals, Humans, Pyrroles, Furans, Cell Proliferation, Combretastatin, Cell growth, Antimitotic Drug, Bioavailability, Solubility, chemistry, Drug Resistance, Neoplasm, Apoptosis, Cell culture, Indole, Drug Design, Drug Screening Assays, Antitumor, Colchicine

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::982e1c6a1e422676ace27810974272c2Test
http://hdl.handle.net/11588/415081Test