A novel mouse model of diabetes, atherosclerosis and fatty liver disease using an AAV8-PCSK9-D377Y injection and dietary manipulation in db/db mice

التفاصيل البيبلوغرافية
العنوان: A novel mouse model of diabetes, atherosclerosis and fatty liver disease using an AAV8-PCSK9-D377Y injection and dietary manipulation in db/db mice
المؤلفون: Mengyun Xu, Xiumei Wu, Zhenghong Liu, Yu Ding, Weian Kong, Peter J. Little, Suowen Xu, Jianping Weng
المصدر: Biochemical and Biophysical Research Communications. 622:163-169
بيانات النشر: Elsevier BV, 2022.
سنة النشر: 2022
مصطلحات موضوعية: Mice, Knockout, Liver Diseases, Hypercholesterolemia, Biophysics, Cell Biology, Atherosclerosis, Biochemistry, Plaque, Atherosclerotic, Diet, Fatty Liver, Mice, Inbred C57BL, Disease Models, Animal, Mice, Apolipoproteins E, Cholesterol, Diabetes Mellitus, Type 2, Receptors, LDL, Animals, Proprotein Convertase 9, Molecular Biology
الوصف: Preclinical mouse models of cardiometabolic diseases are crucial to study the pathological mechanisms of cardiometabolic diseases and to explore potential new therapeutic agents. Using double-knockouts in the background of ApoE
تدمد: 0006-291X
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d53a7475e182846aa2dca9b40812a912Test
https://doi.org/10.1016/j.bbrc.2022.07.031Test
حقوق: CLOSED
رقم الانضمام: edsair.doi.dedup.....d53a7475e182846aa2dca9b40812a912
قاعدة البيانات: OpenAIRE