المؤلفون: Thomas, Liz, Chutani, Namita, R, Krishna, Nair, Asha S., Yellapu, Nanda Kumar, Karyala, Prashanthi, Pakala, Suresh B.

المساهمون: University of Hyderabad

المصدر: Biochemical Journal ; volume 480, issue 20, page 1675-1691 ; ISSN 0264-6021 1470-8728

مصطلحات موضوعية: Cell Biology, Molecular Biology, Biochemistry

الوصف: Although Microrchidia 2 (MORC2) is widely overexpressed in human malignancies and linked to cancer cell proliferation, metabolism, and metastasis, the mechanism of action of MORC2 in cancer cell migration and invasion is yet undeciphered. Here, we identified for the first time that MORC2, a chromatin remodeler, regulates E-cadherin expression and, subsequently regulates breast cancer cell migration and invasion. We observed a negative correlation between the expression levels of MORC2 and E-cadherin in breast cancer. Furthermore, the overexpression of MORC2 resulted in decreased expression levels of E-cadherin. In addition, co-immunoprecipitation and chromatin immunoprecipitation assays revealed that MORC2 interacts with HDAC1 and gets recruited onto the E-cadherin promoter to inhibit its transcription, thereby suppress its expression. Consequently, knockdown of HDAC1 in MORC2-overexpressing cells led to reduced cancer cell migration and invasion. Interestingly, we noticed that MORC2-regulated glucose metabolism via c-Myc, and LDHA, also modulates the expression of E-cadherin. Collectively, these results demonstrate for the first time a mechanistic role for MORC2 as an upstream regulator of E-cadherin expression and its associated functions in breast cancer.

الإتاحة: https://doi.org/10.1042/bcj20230304Test
https://portlandpress.com/biochemj/article-pdf/480/20/1675/950944/bcj-2023-0304.pdfTest

المؤلفون: Pakala, Suresh B., Bui-Nguyen, Tri M., Reddy, Sirigiri Divijendra Natha, Li, Da-Qiang, Peng, Shaohua, Rayala, Suresh K., Behringer, Richard R., Kumar, Rakesh

المصدر: Journal of Biological Chemistry ; volume 292, issue 11, page 4764 ; ISSN 0021-9258

مصطلحات موضوعية: Cell Biology, Molecular Biology, Biochemistry

الإتاحة: https://doi.org/10.1074/jbc.a117.139469Test
https://api.elsevier.com/content/article/PII:S0021925820521996?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S0021925820521996?httpAccept=text/plainTest

المؤلفون: Bui-Nguyen, Tri M., Pakala, Suresh B., Sirigiri, Divijendranatha Reddy, Martin, Emil, Murad, Ferid, Kumar, Rakesh

المصدر: Journal of Biological Chemistry ; volume 292, issue 11, page 4765 ; ISSN 0021-9258

مصطلحات موضوعية: Cell Biology, Molecular Biology, Biochemistry

الإتاحة: https://doi.org/10.1074/jbc.a117.065987Test
https://api.elsevier.com/content/article/PII:S002192582052200X?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S002192582052200X?httpAccept=text/plainTest

المؤلفون: Bui-Nguyen, Tri M., Pakala, Suresh B., Sirigiri, Divijendranatha Reddy, Martin, Emil, Murad, Ferid, Kumar, Rakesh

المصدر: Journal of Biological Chemistry ; volume 291, issue 3, page 1198 ; ISSN 0021-9258

مصطلحات موضوعية: Cell Biology, Molecular Biology, Biochemistry

الإتاحة: https://doi.org/10.1074/jbc.a109.065987Test
https://api.elsevier.com/content/article/PII:S0021925820361500?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S0021925820361500?httpAccept=text/plainTest

المؤلفون: Pakala, Suresh B., Bui-Nguyen, Tri M., Reddy, Sirigiri Divijendra Natha, Li, Da-Qiang, Peng, Shaohua, Rayala, Suresh K., Behringer, Richard R., Kumar, Rakesh

المصدر: Journal of Biological Chemistry ; volume 291, issue 3, page 1198 ; ISSN 0021-9258

مصطلحات موضوعية: Cell Biology, Molecular Biology, Biochemistry

الإتاحة: https://doi.org/10.1074/jbc.a110.139469Test
https://api.elsevier.com/content/article/PII:S0021925820361494?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S0021925820361494?httpAccept=text/plainTest

المؤلفون: Marzook, Hezlin, Li, Da-Qiang, Nair, Vasudha S., Mudvari, Prakriti, Reddy, Sirigiri Divijendra Natha, Pakala, Suresh B., Santhoshkumar, T.R., Pillai, M. Radhakrishna, Kumar, Rakesh

المصدر: Journal of Biological Chemistry ; volume 290, issue 11, page 6751 ; ISSN 0021-9258

مصطلحات موضوعية: Cell Biology, Molecular Biology, Biochemistry

الإتاحة: https://doi.org/10.1074/jbc.a114.314088Test
https://api.elsevier.com/content/article/PII:S0021925820767529?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S0021925820767529?httpAccept=text/plainTest

المؤلفون: Sankaran, Deivendran, Pakala, Suresh B., Nair, Vasudha S., Sirigiri, Divijendra Natha Reddy, Cyanam, Dinesh, Ha, Ngoc-Han, Li, Da-Qiang, Santhoshkumar, T.R., Pillai, M. Radhakrishna, Kumar, Rakesh

المصدر: Journal of Biological Chemistry ; volume 288, issue 36, page 26177 ; ISSN 0021-9258

مصطلحات موضوعية: Cell Biology, Molecular Biology, Biochemistry

الإتاحة: https://doi.org/10.1074/jbc.a111.324632Test
https://api.elsevier.com/content/article/PII:S0021925820536120?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S0021925820536120?httpAccept=text/plainTest

المؤلفون: Pakala, Suresh B., Nair, Vasudha S., Reddy, Sirigiri DivijendraNatha, Kumar, Rakesh

المصدر: Journal of Biological Chemistry ; volume 287, issue 48, page 40560-40569 ; ISSN 0021-9258

مصطلحات موضوعية: Cell Biology, Molecular Biology, Biochemistry

الإتاحة: https://doi.org/10.1074/jbc.m112.399576Test
https://api.elsevier.com/content/article/PII:S0021925820621986?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S0021925820621986?httpAccept=text/plainTest

المؤلفون: Marzook, Hezlin, Li, Da-Qiang, Nair, Vasudha S., Mudvari, Prakriti, Reddy, Sirigiri Divijendra Natha, Pakala, Suresh B., Santhoshkumar, T.R., Pillai, M. Radhakrishna, Kumar, Rakesh

المصدر: Journal of Biological Chemistry ; volume 287, issue 15, page 12158 ; ISSN 0021-9258

مصطلحات موضوعية: Cell Biology, Molecular Biology, Biochemistry

الإتاحة: https://doi.org/10.1074/jbc.a111.314088Test
https://api.elsevier.com/content/article/PII:S002192582053144X?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S002192582053144X?httpAccept=text/plainTest

المؤلفون: Sankaran, Deivendran, Pakala, Suresh B., Nair, Vasudha S., Sirigiri, Divijendra Natha Reddy, Cyanam, Dinesh, Ha, Ngoc-Han, Li, Da-Qiang, Santhoshkumar, T.R., Pillai, M. Radhakrishna, Kumar, Rakesh

المصدر: Journal of Biological Chemistry ; volume 287, issue 8, page 5483-5491 ; ISSN 0021-9258

مصطلحات موضوعية: Cell Biology, Molecular Biology, Biochemistry

الإتاحة: https://doi.org/10.1074/jbc.m111.324632Test
https://api.elsevier.com/content/article/PII:S0021925820612091?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S0021925820612091?httpAccept=text/plainTest