المؤلفون: Alex K. Heer, Manfred Kopf, Josef M. Penninger, Samuel Philip Nobs, Owen M. Siggs, Christoph Schneider, Emilio Hirsch

المصدر: Journal of Leukocyte Biology, 101 (2)

مصطلحات موضوعية: Male, 0301 basic medicine, Transgene, Respiratory Tract Diseases, Immunology, Context (language use), Disease, Mucin 2, Biology, medicine.disease_cause, PI3K, Article, Mice, 03 medical and health sciences, Orthomyxoviridae Infections, Macrophages, Alveolar, medicine, Animals, Class Ib Phosphatidylinositol 3-Kinase, Immunology and Allergy, GM-CSF receptor, influenza, mucin 2, Crosses, Genetic, PI3K/AKT/mTOR pathway, Mice, Knockout, Mutation, Granulocyte-Macrophage Colony-Stimulating Factor, Cancer, Cell Biology, Orthomyxoviridae, medicine.disease, Mice, Inbred C57BL, 030104 developmental biology, Receptors, Granulocyte-Macrophage Colony-Stimulating Factor, Female, Disease Susceptibility, Signal transduction, Signal Transduction

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89c170af615478c8175c7dc4f3c5bfaaTest
https://hdl.handle.net/20.500.11850/181333Test

المؤلفون: Adrian Liston, Christopher C. Goodnow, Owen M. Siggs

مصطلحات موضوعية: CD4-Positive T-Lymphocytes, endocrine system, immune tolerance, mice, Immunology, regulatory t-cells, interleukin-2 gene, selection, Mice, Transgenic, chemical and pharmacologic phenomena, Thymus Gland, CD8-Positive T-Lymphocytes, Biology, Lymphocyte Activation, interleukin 2, Clonal deletion, Islets of Langerhans, Mice, Interleukin 21, self, foxp3, Immune Tolerance, Animals, Immunology and Allergy, Cytotoxic T cell, autoimmune diseases, IL-2 receptor, Antigen-presenting cell, Interleukin 3, lacking, ZAP70, autoimmune-disease, Forkhead Transcription Factors, regulatory t cells, Cell Biology, Flow Cytometry, Natural killer T cell, Cell biology, Diabetes Mellitus, Type 1, Interleukin-2, activation, beta

وصف الملف: Print-Electronic; application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f5c7d962272c8cbf5f13952f557baafTest
https://doi.org/10.1038/sj.icb.7100049Test

المؤلفون: Owen M. Siggs

المصدر: Immunology and Cell Biology

مصطلحات موضوعية: Genotype, Immunology, Population, Mutagenesis (molecular biology technique), Context (language use), Review, Biology, medicine.disease_cause, Genome, medicine, Immunology and Allergy, CRISPR, Animals, Humans, genetics, education, Gene, Genetic Association Studies, Genetics, Mammals, education.field_of_study, Mutation, Cas9, Immunity, Cell Biology, 3. Good health, Phenotype

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef9dd497da5923af7de965ed04802137Test
https://doi.org/10.1038/icb.2014.8Test

المؤلفون: Adrian V. S. Hill, Sascha N. Klimosch, Benedikt Klesser, Bruce Beutler, Bélnéldicte Manoury, Elham Khatamzas, Alice Mayer, Alison Simmons, Kieran Zausmer, Tica Pichulik, Dominik Hartl, Andreas Hector, Alexander N.R. Weber, Anna Rautanen, Elif Colak, Alasdair Leslie, Roman Fischer, Martin Frank, Andriy V. Kubarenko, Owen M. Siggs

مصطلحات موضوعية: Immunology, Biology, Article, chemistry.chemical_compound, Mice, Immunology and Allergy, Animals, Humans, Genetics, Oligoribonucleotides, Effector, Quinolinium Compounds, Pattern recognition receptor, RNA, TLR7, TLR8, Cell biology, Protein Structure, Tertiary, Imidazoquinoline, HEK293 Cells, chemistry, Ectodomain, Toll-Like Receptor 7, Toll-Like Receptor 8, Signal transduction, Signal Transduction

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77f1b44c04db6dc8e3cba5cd9048845eTest
https://doi.org/10.4049/jimmunol.1303058Test

المؤلفون: Francesca Pasutto, Steve Rozen, Keri F. Allen, Terri L. Young, Shahrbanou Javadiyan, Tiger Zhou, Tomokazu Souma, Stuart W. Tompson, Kathryn P. Burdon, Kristina N. Whisenhunt, Simone Finzi, Khanh Nhat Tran-Viet, Shinji Yamaguchi, David A. Mackey, Jing Jin, Dimitar N. Azmanov, Sing Hui Lim, Sebastian Maurer-Stroh, Bethany A. Kloss, Alex W. Hewitt, Jonathan B Ruddle, Janey L. Wiggs, Krishnakumar Kizhatil, Jamie E Craig, Benjamin R. Thomson, Emmanuelle Souzeau, Susan E. Quaggin, Luba Kalaydjieva, Simon W. M. John, Xiaorong Liu, Vachiranee Limviphuvadh, Lucia Mauri, Owen M. Siggs, Tammy L. Yanovitch, Liang Feng

المساهمون: School of Biological Sciences

المصدر: The Journal of clinical investigation. 126(7)

مصطلحات موضوعية: 0301 basic medicine, Pathology, genetic structures, Gene Dosage, Glaucoma, medicine.disease_cause, Ligands, Mice, Medicine, Missense mutation, Exome, Phosphorylation, Mice, Knockout, Mutation, biology, General Medicine, Angiopoietin receptor, Receptor, TIE-2, Cell biology, Pedigree, medicine.anatomical_structure, Phenotype, primary congenital glaucoma, Haploinsufficiency, Signal Transduction, Research Article, medicine.medical_specialty, CYP1B1, Mutation, Missense, Mice, Transgenic, 03 medical and health sciences, angiopoietin receptor TEK, Trabecular Meshwork, Animals, Humans, Loss function, Intraocular Pressure, Family Health, business.industry, medicine.disease, eye diseases, 030104 developmental biology, Gene Expression Regulation, biology.protein, Trabecular meshwork, sense organs, business, Angiopoietins

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1fdc4703ba7fd7930ce3ff130d9e61b1Test
https://pubmed.ncbi.nlm.nih.gov/27270174Test

المؤلفون: Antti Niemistö, Alan Aderem, M. Kristina Hamilton, Jacques J. Peschon, Owen M. Siggs, Daniel E. Zak, Kathleen A. Kennedy, Shannon G. Fallen, Bruce Beutler, Rosa Suen, Elizabeth S. Gold, Joe S. Valvo, Frank Schmitz, Carrie D. Johnson, Tetyana Stolyar, Alan H. Diercks, Irina Podolsky

المصدر: Proceedings of the National Academy of Sciences. 108:11536-11541

مصطلحات موضوعية: Systems Analysis, Biology, medicine.disease_cause, Mice, Protein Interaction Mapping, IKBKG, medicine, Animals, SHARPIN Gene, Transcription factor, DNA Primers, Mice, Knockout, Toll-like receptor, Mutation, Multidisciplinary, Base Sequence, Macrophages, Systems Biology, Intracellular Signaling Peptides and Proteins, NF-kappa B, Biological Sciences, Molecular biology, Immunity, Innate, Toll-Like Receptor 2, Cell biology, Mice, Inbred C57BL, Transcription Factor AP-1, TLR2, IκBα, Signal transduction, Carrier Proteins, Signal Transduction

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d0d1bad5803b7d80c86b1b75b1469e4Test
https://doi.org/10.1073/pnas.1107577108Test

المؤلفون: David Nemazee, Pei Lin, Owen M. Siggs, Bruce Beutler, Elaine Pirie, Christoph Huber, Yu Xia, Carrie N. Arnold

المصدر: Nature immunology

مصطلحات موضوعية: Male, Genotype, ATPase, Immunology, Mice, Transgenic, Context (language use), Article, Immunophenotyping, Mice, Bone Marrow, B cell development, medicine, Animals, Immunology and Allergy, Lymphopoiesis, Progenitor cell, B cell, Adenosine Triphosphatases, B-Lymphocytes, Mice, Inbred BALB C, Mice, Inbred C3H, Fetus, IL-7, biology, Reverse Transcriptase Polymerase Chain Reaction, Interleukin-7, Gene Expression Regulation, Developmental, flippase, Molecular biology, Cell biology, Mice, Inbred C57BL, medicine.anatomical_structure, Immunoglobulin M, Trans-Activators, biology.protein, RNA, Female, Bone marrow, fetal liver

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c5f3b044b8ee2bf254a0bbe8c2167c0Test
https://doi.org/10.1038/ni.2012Test

المؤلفون: Adam G. Grieve, Owen M. Siggs, Yonka Christova, Matthew Freeman, Paul Bambrough, Hongmei Xu

المصدر: Biology Open
Biology Open, Vol 3, Iss 12, Pp 1151-1157 (2014)

مصطلحات موضوعية: Proteases, Rhbdf2, Mouse, QH301-705.5, medicine.medical_treatment, Science, Mutant, RHBDF2, Amphiregulin, General Biochemistry, Genetics and Molecular Biology, Rhomboid, medicine, Epidermal growth factor receptor, Biology (General), Genetics, TACE, ADAM17, biology, fungi, Wild type, iRhom, Cell biology, Cytokine, biology.protein, General Agricultural and Biological Sciences, Research Article

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb0192140cace9b4391f83e8ee8470d4Test
http://ora.ox.ac.uk/objects/uuidTest:

المؤلفون: Adele L. Yates, Christopher C. Goodnow, Adrian Liston, Sylvie Lesage, Susan M. Schlenner, Owen M. Siggs

المصدر: Immunology. 141(4)

مصطلحات موضوعية: Antigens, Differentiation, T-Lymphocyte, Male, Genotype, Immunology, Mutation, Missense, chemical and pharmacologic phenomena, Mice, Transgenic, Biology, CD5 Antigens, Mice, Costimulatory and Inhibitory T-Cell Receptors, Antigens, CD, Immunology and Allergy, Animals, Lectins, C-Type, Receptor, Cells, Cultured, Thymocytes, ZAP-70 Protein-Tyrosine Kinase, ZAP70, T-cell receptor, hemic and immune systems, Molecular biology, Mice, Mutant Strains, Cell biology, Up-Regulation, Mice, Inbred C57BL, Thymocyte, Phenotype, Protein kinase domain, Original Article, CD5, Tyrosine kinase, Proto-oncogene tyrosine-protein kinase Src, Signal Transduction

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44017bb517f7f35a6ec74243850ff786Test
https://pubmed.ncbi.nlm.nih.gov/24266404Test

المؤلفون: Bruce Beutler, Owen M. Siggs

مصطلحات موضوعية: Genetics, Zinc finger, Extra Views, Lymphopoiesis, Immunity, Zinc Fingers, Cell Biology, Biology, Models, Biological, Cell biology, Haematopoiesis, Immune system, Hematologic Neoplasms, Gene expression, Animals, Humans, Molecular Biology, Gene, Transcription factor, Function (biology), Developmental Biology, Transcription Factors

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc3042359254e39f50b38fa3865a99aaTest
https://europepmc.org/articles/PMC3466544Test/