المؤلفون: Dickson Mambwe, Dina Coertzen, Meta Leshabane, Mwila Mulubwa, Mathew Njoroge, Liezl Gibhard, Gareth Girling, Kathryn J. Wicht, Marcus C. S. Lee, Sergio Wittlin, Diogo Rodrigo Magalhães Moreira, Lyn-Marie Birkholtz, Kelly Chibale

مصطلحات موضوعية: Biochemistry, Cell Biology, Genetics, Pharmacology, Biotechnology, Cancer, Virology, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, synthesized analogues based, suggesting activity via, previously identified 3, new azabenzimidazole analogues, multistage antiplasmodium activity, mouse infection model, cardiotoxicity liability associated, astemizole toward addressing, antiplasmodium activity profile, antimalarial drug astemizole, oxadiazole ast analogue, fold higher selectivity, plasmodium berghei <, int , h , 50 , 63 μm ), 150 μm ), 11 , cross resistance profiling, 4

العلاقة: https://figshare.com/articles/journal_contribution/hERG_i_Plasmodium_i_Life_Cycle_and_Cross_Resistance_Profiling_of_New_Azabenzimidazole_Analogues_of_Astemizole/25427444Test

الإتاحة: https://doi.org/10.1021/acsmedchemlett.3c00496.s001Test

المؤلفون: Jennifer A. Yang, Bing Yu Zou, Frances Rocamora, Edgar Vigil, Prianka Kumar, Nina F. Gnädig, Alan F. Cowman, David A. Fidock, Roy Williams, Trevor Johnson, Madeline R. Luth, Danushka S. Marapana, Dylan Hutson, Marcus C. S. Lee, Tilla S. Worgall, Jianbo Huang, Gregory M. Goldgof, Gregory LaMonte, T. R. Santha Kumar, Jennifer K. Thompson, Timothy J. Egan, Roxanne Mohunlal, Sabine Ottilie, Dionicio Siegel, Elizabeth A. Winzeler, Andrea L. Cheung

المصدر: Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
Nature Communications
Nature communications, vol 11, iss 1

مصطلحات موضوعية: 0301 basic medicine, ved/biology.organism_classification_rank.species, Protozoan Proteins, General Physics and Astronomy, Synthetic lethality, Endoplasmic Reticulum, Plasmodium, Mass Spectrometry, chemistry.chemical_compound, 2.1 Biological and endogenous factors, 2.2 Factors relating to the physical environment, Aetiology, lcsh:Science, Chromatography, High Pressure Liquid, Chromatography, Multidisciplinary, Secretory Pathway, biology, Brefeldin A, Cell biology, Infectious Diseases, 5.1 Pharmaceuticals, High Pressure Liquid, HIV/AIDS, Development of treatments and therapeutic interventions, medicine.symptom, Infection, Science, 030106 microbiology, Saccharomyces cerevisiae, Plasmodium falciparum, General Biochemistry, Genetics and Molecular Biology, Article, 03 medical and health sciences, Antimalarials, Inhibitory Concentration 50, Rare Diseases, Target identification, parasitic diseases, medicine, Secretion, Model organism, Gene, Secretory pathway, ved/biology, Endoplasmic reticulum, Autophagy, General Chemistry, biology.organism_classification, Malaria, Vector-Borne Diseases, Good Health and Well Being, 030104 developmental biology, chemistry, Mechanism of action, Pyrazoles, lcsh:Q

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b18290350407667761814a3f37b90a3Test
https://doaj.org/article/30325ebc8f1440eb95a7ef787cbdca69Test

المؤلفون: Frances Rocamora (4962571), Purva Gupta (4873264), Eva S. Istvan (10302503), Madeline R. Luth (4723521), Emma F. Carpenter (10302506), Krittikorn Kümpornsin (10302509), Erika Sasaki (121830), Jaeson Calla (8530788), Nimisha Mittal (4019684), Krypton Carolino (10302512), Edward Owen (10302515), Manuel Llinás (10302518), Sabine Ottilie (3601928), Daniel E. Goldberg (449198), Marcus C. S. Lee (7553543), Elizabeth A. Winzeler (84966)

مصطلحات موضوعية: Biochemistry, Microbiology, Cell Biology, Genetics, Pharmacology, Evolutionary Biology, Cancer, Infectious Diseases, Computational Biology, Environmental Sciences not elsewhere classified, Physical Sciences not elsewhere classified, resistance, antimalarial, Whole genome sequencing, compound, sensitivity, MFS, mutation, napthoquinone phenotypic screening hits, gene, mitochondrial, pfmfr 3, cytochrome bc 1. Green, GNF-Pf -3600, sexual-stage P . falciparum parasites, apicomplexan transporter PF 3D, MMV 085203, mechanism, dihydroorotate dehydrogenase rescue., GFP

العلاقة: https://figshare.com/articles/dataset/PfMFR3_A_Multidrug-Resistant_Modulator_in_i_Plasmodium_falciparum_i_/14214860Test

الإتاحة: https://doi.org/10.1021/acsinfecdis.0c00676.s001Test

المؤلفون: Kim C. Heimsch, Gavreel Kalantarov, Marcus C. S. Lee, Sachel Mok, Michal Kuderjavy, Judith Straimer, Barbara H. Stokes, Audrey R. Odom John, Katja Becker, Ilya Trakht, David A. Fidock, Rachel L. Edwards, Nina F. Gnädig, Audrey Crane

المصدر: PLoS Pathogens
PLoS Pathogens, Vol 16, Iss 4, p e1008482 (2020)

مصطلحات موضوعية: Plasmodium, medicine.medical_treatment, Cell Membranes, Mutant, Drug Resistance, Protozoan Proteins, Vacuole, Endoplasmic Reticulum, Biochemistry, Parasite hosting, Biology (General), Malaria, Falciparum, Energy-Producing Organelles, 0303 health sciences, Secretory Pathway, biology, 030302 biochemistry & molecular biology, Artemisinins, Mitochondria, Cell biology, Cell Processes, Cellular Structures and Organelles, Research Article, QH301-705.5, Plasmodium falciparum, Immunology, Dihydroartemisinin, Bioenergetics, Microbiology, Antimalarials, 03 medical and health sciences, Virology, DNA-binding proteins, Parasite Groups, parasitic diseases, Genetics, medicine, Humans, Trophozoites, Hemoglobin, Vesicles, Molecular Biology, 030304 developmental biology, Endoplasmic reticulum, Biology and Life Sciences, Proteins, Membrane Proteins, Cell Biology, RC581-607, biology.organism_classification, Membrane protein, Mutation, Parasitology, Rab, Immunologic diseases. Allergy, Apicomplexa

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::043e5f5e56ae46495765fd5c64668dd4Test
https://doi.org/10.1371/journal.ppat.1008482Test

المؤلفون: Pablo Bifani, Elizabeth A. Winzeler, Victoria C. Corey, David A. Fidock, Christin Reimer, Benoit Malleret, Bianca F Bf Tjahjadi, Bee Huat Tan, Thierry T. Diagana, Marcus C. S. Lee, Laurent Rénia, Bryan K. S. Yeung, Paul Chi-Lui Pc Ho, Liting L. Lim, René Wintjens, Michelle Yi-Xiu Lim, Eric D. Chow, Peter Gedeck, Marie Nachon, Gregory G. LaMonte, Adeline C. Y. Chua, Ghislain M. C. Bonamy

المصدر: Nature microbiology

مصطلحات موضوعية: 0301 basic medicine, Microbiology (medical), 030106 microbiology, Immunology, Mutant, Drug resistance, Bioinformatics, Applied Microbiology and Biotechnology, Microbiology, Article, 03 medical and health sciences, parasitic diseases, Genetics, Medicine, CRISPR, Plasmodium berghei, Gene, biology, business.industry, Plasmodium falciparum, Transporter, Cell Biology, biology.organism_classification, 3. Good health, Multiple drug resistance, 030104 developmental biology, Biochemistry, business

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e96c53daeb850f1c4ad21fa8c0ec7572Test
https://doi.org/10.1038/nmicrobiol.2016.166Test

المؤلفون: Philip D. Gregory, Jocelynn R. Pearl, Edward J. Rebar, Lei Zhang, Manuel Llinás, David A. Fidock, Marcus C. S. Lee, Fyodor D. Urnov, Judith Straimer, Andrew H. Lee, April E. Williams, Bryan Zeitler

المصدر: Nature Methods. 9:993-998

مصطلحات موضوعية: Molecular Sequence Data, Plasmodium falciparum, Drug Resistance, Locus (genetics), Biology, Protein Engineering, Biochemistry, Genome, Article, Genome editing, parasitic diseases, Molecular Biology, Gene, Alleles, Genetics, Zinc finger, Base Sequence, Point mutation, Chloroquine, Zinc Fingers, Cell Biology, Endonucleases, biology.organism_classification, Zinc finger nuclease, Genome, Protozoan, Biotechnology

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::943e45534d08a65c009f42d9bfe5a35bTest
https://doi.org/10.1038/nmeth.2143Test

المؤلفون: Marcus C. S. Lee, Mariana Dorrington, Leslie Kung, Elizabeth A. Miller, Silvere Pagant

المصدر: Molecular Biology of the Cell. 18:3398-3413

مصطلحات موضوعية: Cytoplasm, Protein Folding, Saccharomyces cerevisiae Proteins, Recombinant Fusion Proteins, Amino Acid Motifs, Saccharomyces cerevisiae, Protein Sorting Signals, Endoplasmic-reticulum-associated protein degradation, Biology, Endoplasmic Reticulum, Molecular Biology, COPII, Secretory pathway, Endoplasmic reticulum, Vesicle, Membrane Proteins, ER retention, Articles, Cell Biology, HSP40 Heat-Shock Proteins, Transport protein, Cell biology, Protein Transport, Mutation, Ubiquitin-Conjugating Enzymes, ATP-Binding Cassette Transporters, Mutant Proteins, COP-Coated Vesicles, Protein Processing, Post-Translational, Biogenesis, Molecular Chaperones

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7a7284b429524b29be5ee188bdf5f0bTest
https://doi.org/10.1091/mbc.e07-01-0046Test

المؤلفون: Adele M. Lehane, Anupam Pradhan, David A. Fidock, Dennis E. Kyle, Gloria Holbrook, Amy Matheny, Martina Sigal, Anang A. Shelat, David Waterson, Iñigo Angulo-Barturen, Kathleen O’Loughlin, Jian Liu, Laura M. Sanz, Philip D. Stein, Daniel H. Ebert, Kiaran Kirk, Hongshen Ma, Marcus C. S. Lee, Jon C. Mirsalis, W. Armand Guiguemde, Xiaoyan Deng, Greg Fedewa, Ane Rodríguez-Alejandre, María Belén Jiménez-Díaz, María G. Gómez, Angela K. Carrillo, Mariana Justino de Almeida, Yandira G. Salinas, Vicky M. Avery, David M. Shackleford, Sandra Duffy, Marie-Eve Myrand-Lapierre, Gregory M. Miller, María Santos Martínez, Adelaide S. M. Dennis, Charles C. Kim, R. Kiplin Guy, Julie Clark, Jeremy A. Horst, Aaron N. Endsley, Joseph L. DeRisi, Zheng Wang, Spencer Knapp, Fangyi Zhu, David M. Floyd, Santiago Ferrer, Jonathon Diep, Francisco-Javier Gamo, Susan A. Charman, Natalie J. Spillman

المصدر: Proceedings of the National Academy of Sciences of the United States of America, vol 111, iss 50

مصطلحات موضوعية: Models, Molecular, Plasmodium, Erythrocytes, Drug Resistance, Drug resistance, Pharmacology, Corrections, chemistry.chemical_compound, Models, Heterocyclic Compounds, Drug Discovery, 2.1 Biological and endogenous factors, 2.2 Factors relating to the physical environment, Aetiology, Cellular Senescence, PfATP4, Multidisciplinary, Molecular Structure, Drug discovery, Flow Cytometry, Cell biology, Infectious Diseases, PNAS Plus, 5.1 Pharmaceuticals, Development of treatments and therapeutic interventions, Infection, Cell aging, Intracellular, Phenotypic screening, malaria, Calcium-Transporting ATPases, Biology, Heterocyclic Compounds, 4 or More Rings, drug discovery, Antimalarials, Rare Diseases, In vivo, Prevention, Molecular, Plasmodium falciparum, 4 or More Rings, biology.organism_classification, Isoquinolines, Cipargamin, High-Throughput Screening Assays, Malaria, Vector-Borne Diseases, Orphan Drug, Good Health and Well Being, chemistry

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd38753b4b27787a1d271647ca26a4f8Test
https://europepmc.org/articles/PMC4273362Test/

المؤلفون: Leslie J. Street, David Waterson, Robert W. Sauerwein, Jeremy N. Burrows, Claire Le Manach, Sara E. Zakutansky, Karen L. White, Suresh Solapure, Yassir Younis, Anne-Marie Zeeman, Michael J Witty, Santiago Ferrer, Mariette Botha, Marcus Bantscheff, Susan A. Charman, Kennan C. Marsh, Christian Scheurer, Francisco-Javier Gamo, Rosemary Rochford, Rajshekhar Basak, Janette Reader, María Belén Jiménez-Díaz, Sonja Ghidelli-Disse, Chek Shik Lim, Clemens H. M. Kocken, Lyn-Marie Birkholtz, Kelly Chibale, Kirsten K. Hanson, Didier Leroy, Brice Campo, Koen J. Dechering, Andrea Ruecker, David M. Shackleford, Pattaraporn Vanachayangkul, Tara S. Abraham, Sergio Wittlin, Cristina Donini, Christophe Bodenreider, Iñigo Angulo-Barturen, David A. Fidock, Marcus C. S. Lee, Diego Gonzàlez Cabrera, Maria Jose Lafuente-Monasterio, María Santos Martínez, Julia Morizzi, Michael J. Delves, Tanya Paquet, Andrew M. Blagborough, Anchalee Tungtaeng, Laura M. Sanz, Janne Mannila, Gerard Drewes, Philipp P. Henrich

المساهمون: Medical Research Council (MRC), Bill & Melinda Gates Foundation

المصدر: Repositorio Institucional de la Consejería de Sanidad de la Comunidad de Madrid
Consejería de Sanidad de la Comunidad de Madrid
Science Translational Medicine, 9, 387, pp. pii: eaad9735-pii: eaad9735
Science Translational Medicine, 9, pii: eaad9735-pii: eaad9735

مصطلحات موضوعية: 0301 basic medicine, Male, Plasmodium, lnfectious Diseases and Global Health Radboud Institute for Molecular Life Sciences [Radboudumc 4], FALCIPARUM, Aminopyridines, Mice, SCID, Research & Experimental Medicine, Pharmacology, chemistry.chemical_compound, Mice, Parasitic Sensitivity Tests, Sulfones, 1-Phosphatidylinositol 4-Kinase, biology, Drug discovery, Kinase, 11 Medical And Health Sciences, General Medicine, 3. Good health, Medicine, Research & Experimental, NEXT-GENERATION, Female, Life Sciences & Biomedicine, TRANSMISSION, DNA-SEQUENCING DATA, Article, 03 medical and health sciences, Antimalarials, MALARIA PARASITES, parasitic diseases, medicine, Animals, Plasmodium berghei, Phosphatidylinositol, SINGLE-DOSE CURE, Science & Technology, KINASE INHIBITORS, Chemoprotection, Plasmodium falciparum, Cell Biology, IN-VITRO, QUANTIFICATION, 06 Biological Sciences, biology.organism_classification, medicine.disease, Virology, In vitro, Malaria, DRUG DISCOVERY, 030104 developmental biology, chemistry

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b23e9098067be7ceed4060830e651c9eTest
https://hdl.handle.net/2066/177492Test

المؤلفون: Silvere Pagant, Indira Singh, Elizabeth A. Miller, John L. Hartman, Marcus C. S. Lee, Justine Barry, Alenka Čopič, Mariana Dorrington

المصدر: Genetics. 182(3)

مصطلحات موضوعية: Protein Folding, Glycosylation, Saccharomyces cerevisiae Proteins, Receptors, Peptide, Immunoblotting, Golgi Apparatus, GET complex, Saccharomyces cerevisiae, Investigations, Endoplasmic Reticulum, Models, Biological, Chromatin remodeling, Fungal Proteins, Histones, symbols.namesake, chemistry.chemical_compound, Genetics, Homeostasis, Immunoprecipitation, HSP70 Heat-Shock Proteins, Fungal protein, biology, Endoplasmic reticulum, Acetylation, Golgi apparatus, Cell biology, Histone, Secretory protein, chemistry, Mutation, symbols, biology.protein, Genome, Fungal, Protein Processing, Post-Translational, Signal Transduction

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b65b27fd564cbef61744311f16249438Test
https://pubmed.ncbi.nlm.nih.gov/19433630Test